A5026406196- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Advanced Battery Technologies Research
- Advanced Battery Materials and Technologies
- Mathematical and Theoretical Epidemiology and Ecology Models
- Advancements in Battery Materials
- Solidification and crystal growth phenomena
- Immunotherapy and Immune Responses
- COVID-19 and Mental Health
- Poxvirus research and outbreaks
- Theoretical and Computational Physics
- Viral Infections and Outbreaks Research
- Bacillus and Francisella bacterial research
- Enhanced Oil Recovery Techniques
- Nonlinear Dynamics and Pattern Formation
- COVID-19 Clinical Research Studies
- nanoparticles nucleation surface interactions
- Stochastic processes and statistical mechanics
- Vaccine Coverage and Hesitancy
- Soil and Unsaturated Flow
- Evolution and Genetic Dynamics
- Vibration and Dynamic Analysis
- SARS-CoV-2 detection and testing
- Virus-based gene therapy research
- Landslides and related hazards
York University
2019-2025
University of Alberta
2023
University of Calgary
2023
Public Health Agency of Canada
2022
University Health Network
2022
University of Toronto
2022
Shanxi University
2022
Toronto Public Health
2022
University of Limerick
2016-2021
University of British Columbia
2014-2015
The lipid nanoparticle (LNP)-formulated mRNA vaccines BNT162b2 and mRNA-1273 are a widely adopted multi vaccination public health strategy to manage the COVID-19 pandemic. Clinical trial data has described immunogenicity of vaccine, albeit within limited study time frame. Here, we use within-host mathematical model for LNP-formulated vaccines, informed by available clinical from 2020 September 2021, project longer term understanding immunity as function vaccine type, dosage amount, age, sex....
Abstract SARS-CoV-2 lipid nanoparticle mRNA vaccines continue to be administered as the predominant prophylactic measure reduce COVID-19 disease pathogenesis. Quantifying kinetics of secondary immune response from subsequent doses beyond primary series and understanding how dose-dependent waning vary a function age, sex, various comorbidities remains an important question. We study anti-spike IgG in 152 individuals who received mRNA-based (first two doses) subset 137 then booster dose. find...
During the SARS-CoV-2 global pandemic, several vaccines, including mRNA and adenovirus vector approaches, have received emergency or full approval. However, supply chain logistics hampered vaccine delivery, which is impacting mass vaccination strategies. Recent studies identified different strategies for dose administration so that constraints issues are diminished. These include increasing time between consecutive doses in a two-dose regimen reducing dosage of second dose. We consider both...
Operating schools safely during the COVID-19 pandemic requires a balance between health risks and need for in-person learning. Using demographic epidemiological data 31 July 23 November 2020 from Toronto, Canada, we developed compartmental transmission model with age, household setting structure to study impact of reopening in September 2020. The simulates home, community schools, accounting differences infectiousness adults children, work-from-home virtual While found slight increase...
Since December 2020, public health agencies have implemented a variety of vaccination strategies to curb the spread SARS-CoV-2, along with pre-existing Nonpharmaceutical Interventions (NPIs). Initial focused on vaccinating elderly prevent hospitalizations and deaths, but vaccines becoming available broader population, it became important determine optimal strategy enable safe lifting NPIs while avoiding virus resurgence.
We present a porous electrode model for lithium-ion batteries using Butler--Volmer reaction kinetics. lithium concentration in both the solid and fluid phase, along with liquid electric potential. Through asymptotic reduction, we show that potentials are spatially homogeneous, which decouples problem into series of time-dependent problems. These problems can be solved on three distinguished time scales: an early scale where capacitance effects dominate, mid-range spatial gradient forms...
A mathematical model of COVID-19 is presented where the decision to increase or decrease social distancing modelled dynamically as a function measured active and total cases well perceived cost isolating. Along with isolation, we define an overburden healthcare cost. We explore these costs by adjusting parameters that could change policy decisions. observe two disease prevention practices, namely increasing isolation activity incentive isolate do not always lead optimal health outcomes....
<h3>Background:</h3> Globally, nonpharmaceutical interventions for COVID-19, including stay-at-home policies, limitations on gatherings and closure of public spaces, are being lifted. We explored the effect lifting a policy virus resurgence under different conditions. <h3>Methods:</h3> Using confirmed case data from Toronto, Canada, between Feb. 24 June 24, 2020, we ran compartmental model with household structure to simulate impact considering levels compliance. estimated threshold values...
We summarize the present form of instability theory for drumlin formation, which describes coupled subglacial flow ice, water and sediment. This model has evolved over last 20 years, is now at point where it can predict instabilities corresponding to ribbed moraine, drumlins mega-scale glacial lineations, but efforts provide numerical solutions have been limited. The summary adds some slight nuances previously published versions theory, notably concerning constitutive description film its...
Abstract Background Seasonal influenza poses a significant public health and economic burden, associated with the outcome of infection resulting complications. The true burden disease is difficult to capture due wide range presentation, from asymptomatic cases non-respiratory complications such as cardiovascular events, its seasonal variability. An understanding magnitude annual incidence important support prevention control policy development evaluate impact preventative measures...
We study the model of Keller & Rubinow (Keller 1981 J. Chem. Phys 74 , 5000–5007. ( doi:10.1063/1.441752 )) describing formation Liesegang rings due to Ostwald's supersaturation mechanism. and provided an approximate solution both for growth equilibration first band, also secondary bands, based on a presumed asymptotic limit. However, they did not provide parametric basis assumptions in their solution, nor any numerical corroboration, particularly band formation. Here, we different...
The transverse stability of localized stripe patterns for certain singularly perturbed two‐component reaction‐diffusion (RD) systems in the asymptotic limit a large diffusivity ratio is analyzed. In this semi‐strong interaction regime, cross‐sectional profile well‐approximated by homoclinic pulse solution corresponding 1‐D problem. linear instability such stripes to perturbations well known from numerical simulations be key mechanism creation spot patterns. However, general, owing difficulty...
Summary Background In many parts of the world, restrictive non-pharmaceutical interventions (NPI) that aim to reduce contact rates, including stay-at-home orders, limitations on gatherings, and closure public places, are being lifted, with possibility epidemic resurges if alternative measures not strong enough. Here we capture combination use NPI’s reopening which will prevent an infection rebound. Methods We employ SEAIR model household structure able policy (SAHP). To reflect changes in...
Disease spread can be affected by pharmaceutical interventions (such as vaccination) and non-pharmaceutical physical distancing, mask-wearing contact tracing). Understanding the relationship between disease dynamics human behaviour is a significant factor to controlling infections. In this work, we propose compartmental epidemiological model for studying how infection of COVID-19 evolves people with different levels social natural immunity vaccine-induced immunity. Our recreates transmission...
We analyze a singularly perturbed reaction-diffusion system in the semistrong diffusion regime two spatial dimensions where an activator species is localized to closed curve, while inhibitor exhibits long-range behavior over domain. In limit of small diffusivity, we derive new moving boundary problem characterizing slow time evolution which defined terms quasi-steady state field and its properties on curve. Numerical results from this curve are illustrated for Gierer--Meinhardt model with...
Abstract A compartment model for an in-host liquid nanoparticle delivered mRNA vaccine is presented. Through non-dimensionalisation, five timescales are identified that dictate the lifetime of in-host: decay interferon gamma, antibody priming, autocatalytic growth, peak and decay, interleukin cessation. asymptotic analysis we able to obtain semi-analytical solutions in each time regimes which allows us predict maximal concentrations better understand parameter dependence model. We compare...
We consider the instability properties of dense granular flow in inclined plane and shear geometries as tests for compressible inertial-dependent rheology. The model, which is a recent generalisation incompressible $\unicode[STIX]{x1D707}(I)$ rheology, constitutes hydrodynamical description allows variability solids volume fraction. perform full linear stability analysis model compare its predictions to existing experimental data glass beads on an discrete element simulations absence...