A5038988303- Epigenetics and DNA Methylation
- Drug-Induced Hepatotoxicity and Protection
- Pesticide Exposure and Toxicity
- Hepatitis B Virus Studies
- Environmental Toxicology and Ecotoxicology
- Synthesis and Characterization of Heterocyclic Compounds
- Immune Response and Inflammation
- Computational Drug Discovery Methods
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Fish Biology and Ecology Studies
- Liver Disease Diagnosis and Treatment
- Identification and Quantification in Food
- Pharmacogenetics and Drug Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Circular RNAs in diseases
- RNA modifications and cancer
- Intensive Care Unit Cognitive Disorders
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
Inserm
2019-2024
Université de Rennes
2019-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023-2024
University of California, San Diego
2024
Nutrition, métabolismes et cancer
2023
Foie, Métabolisme, Cancer
2018
Fish Physiology and Genomics Institute
2016
Severe sepsis induces a sustained immune dysfunction associated with poor clinical behavior. In particular, lymphopenia along increased lymphocyte apoptosis and decreased proliferation, enhanced circulating regulatory T cells (Treg), the emergence of myeloid-derived suppressor (MDSCs) have all been persistent organ dysfunction, secondary infections, late mortality. The mechanisms involved in MDSC-mediated cell during share some features those described malignancies such as arginine...
Intrahepatic cholangiocarcinoma (iCCA) is a deadly liver primary cancer associated with poor prognosis and limited therapeutic opportunities. Active transforming growth factor beta (TGFβ) signaling hallmark of the iCCA microenvironment. However, impact TGFβ on transcriptome tumor cells has been poorly investigated. Here, we have identified specific signature genes commonly deregulated in cell lines, namely HuCCT1 Huh28. Novel coding noncoding targets were identified, including TGFβ-induced...
Hepatitis B virus (HBV) contains a 3.2 kb DNA genome and causes acute chronic hepatitis. HBV infection is global health problem, with 350 million chronically infected people at increased risk of developing liver disease hepatocellular carcinoma (HCC). Methylation in CpG context (5mCpG) can alter the expression patterns viral genes related to cellular transformation. Moreover, it may also provide clues as why certain infections are cleared or persist without progression cancer. The detection...
Human hepatoma HepaRG cells express most drug metabolizing enzymes and constitute a pertinent in vitro alternative cell system to primary cultures of human hepatocytes order determine metabolism evaluate the toxicity xenobiotics. In this work, we established novel transgenic transduced with lentiviruses encoding reporter green fluorescent protein (GFP) transcriptionally regulated by promoter sequences cytochromes P450 (CYP) 1A1/2, 2B6 3A4 genes. Here, demonstrated that GFP-biosensor...
Abstract Pesticides are increasingly recognized to be hepatotoxic but less is known about their toxicity in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent investigations reported oxidative stress-induced apoptosis differentiated hepatocyte-like HepaRG cells after a single treatment with 7-pesticide mixture that included chlorpyrifos, dimethoate, diazinon, iprodione, imazalil, and the dithiocarbamates maneb mancozeb. These effects were reproduced by maneb, mancozeb,...
Abstract Hepatitis B Virus (HBV) is a 3.2KB DNA virus that causes acute and chronic hepatitis. HBV infection world health problem, with 350 million chronically infected people at increased risk of developing liver disease hepatocellular carcinoma (HCC). Methylation in CpG context (5mCpG) can alter the expression patterns viral genes related to cellular transformation. Moreover, it may also provide clues why certain infections are cleared, or persist without progression cancer. The detection...
ABSTRACT The worldwide and intensive use of phytosanitary compounds results in environmental food contamination by chemical residues. Human exposure to multiple pesticide residues is a major health issue. Considering that the liver not only main organ for metabolizing pesticides but also target toxicities induced xenobiotics, we studied effects mixture 7 (chlorpyrifos-ethyl, dimethoate, diazinon, iprodione, imazalil, maneb, mancozeb) often detected samples. Effects was investigated using...