A5045090103- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Circular RNAs in diseases
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Multiple and Secondary Primary Cancers
- Body Contouring and Surgery
- Cancer Cells and Metastasis
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
Medical University of Lodz
2016-2025
AIM:To assess the value of D-dimer level in determining resectability pancreatic cancer. METHODS:Preoperative prediction head cancer remains inaccurate.The use hemostatic factors may be potential help, since D-dimers correlate with tumor stage.Single center clinical trial study comprised patients potentially resectable and without detectable venous thrombosis (n = 64).Resectability was defined as no evidence nodal involvement, distant spread invasion mesenteric vessels.Final decision...
Cancer stem cells (CSC) play an important role in pancreatic carcinogenesis and prognosis. The study aimed at examining the expression of CD24, CD44, CD133 human PDAC CP order to evaluate its clinicopathological correlations clinical significance. Surgical specimens from 23 patients with 15 chronic pancreatitis after resection were stained antibodies. intensity staining was scored 0 (negative) 3 (strongly positive). Results . Mean CD24 score 1.38 ± 0.76 significantly higher than that CP:...
Pancreatic cancer (PDAC) will have been the second leading cancer-related death in United States by 2020, according to current estimation. Its late manifestation and lack of good early detection methods are cause extremely low survival rates. Therefore, there is an urgent need develop highly sensitive specific marker. GDF-15, a member TGFbeta family, has recently emerged as protein playing important role carcinogenesis various neoplasms.Our aim was assess potential IL-17, IL-23 serum...
BACKGROUND: Currently pancreatic cancer is the fourth leading cause of cancer-related death worldwide. Because its late manifestation and consequent dismal prognosis, there an urgent need to develop highly sensitive specific marker. Neutrophil Gelatinase-Associated Lipocalin (NGAL) recent ly emerged as a protein playing important role in carcinogenesis various neoplasms. OBJECTIVE: Our aim was assess potential urine bile concentration NGAL differentiating adenocarcinoma from chronic...
Background.G protein-coupled receptor 35 (GPR35) is involved in carcinogenesis; however, limited experimental data are available on its actual expression patients with colorectal cancer (CRC) and pancreatic adenocarcinoma (PDAC).Objectives.We aimed to measure the relative of GPR35 samples from CRC or PDAC. Materials methods.Using real-time polymerase chain reaction (RT-PCR), we have examined surgery 40 17 PDAC patients, performed analysis results.Results.The revealed correlations between...
The aim of the study was to test hypothesis that results obtained with three different types video laryngoscopes (UESCOPE VL-400, I-View, Non-Channeled Aitraq) and without an endotracheal stylet should be better than a Macintosh laryngoscope in simulated out-of-hospital scenario by person clinical experience. Primary outcome measures were time taken successfully achieve tracheal intubation (TI). Secondary outcomes included grade glottic view (Cormack Lehane grades 1–4), incidence successful...
Background Delayed graft function (DGF) is a common complication following kidney transplantation and associated with ischemia-reperfusion injury (IRI). Lymphocytes contribute to the pathogenesis of IRI related delayed Materials Methods 135 Caucasian patients received from deceased heart-beating organ donors. We divided into 2 groups- eGFR>=30 on 21st day post-transplantation (n=36) eGFR<30 (n=99) assess function. measured serum creatinine levels 1st 2nd post-transplant preoperative...
Background . Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected ductal adenocarcinoma (PDAC) reveals benign in 5% to 13% cases. The aim our study was assess whether routinely used biomarkers such as CA19-9, Ca125, Ca15-3, and CEA, when combined, can potentially yield an accurate test predicting etiology. Methods We retrospectively analyzed data 326 patients who underwent diagnostic process due lesions unknown Results...
ABSTRACT A crucial phase of modern biomarker discovery studies is selecting the most promising features from high-throughput screening assays. Here, we present OmicSelector - Docker-based web application and R package that facilitates analysis such experiments. provides a consistent overfitting-resilient pipeline integrates 94 feature selection approaches based on 25 distinct variable methods. It identifies then ranks best sets using 11 modeling techniques with hyperparameter optimization in...
Background: The need for safe and efficient dissemination of minimally invasive approach in liver surgery is among the current challenges hepatobiliary surgeons. After stage innovators pioneers, following countries should adopt a laparoscopic approach. aim this study was to assess national experience trend implementing resection (LLR) Poland. Materials Methods: A registry LLR performed Poland established June 2020. All cases before were included retrospectively, followed by prospectively...
Actual lymphatic drainage of pancreatic body neoplasms and the proper extent lymphadenectomy remain unknown. The aim study was to define exact draining pattern using dye mapping method.The enrolled patients who were operated on for tumor in Department General Transplant Surgery Medical University Lodz during 2010, with injection 1 ml blue (Patent Blue, Guerbet) centre neoplasm sentinel node identification. Radical surgical management included distal pancreatectomy, whereas gastrojejunal or...
The primary objective of this study was to demonstrate whether the Miller blade laryngoscope could provide better visualization vocal cords in morbidly obese patients than Macintosh laryngoscope. secondary identify patient-measured factors associated with when using vs. blade, as well application external pressure might improve visibility glottis during intubation. A prospective, observational encompassing 110 a BMI > 40 undergoing elective bariatric surgery and intubation procedure...
Cyclooxygenase-2 (COX-2) may play a significant role in the development of pancreatic cancer. One COX-2 main metabolites is prostaglandin E2 (PGE2), which involved both inflammation and carcinogenesis. As PGE2 inactivated lungs liver we assumed that best medium to assess level not peripheral but portal blood.Fifty-seven patients with pathologically verified diagnosis ductal adenocarcinoma (PDAC group, n = 38) chronic pancreatitis (CP 19) were enrolled this study. Sample blood from central...
Introduction: Vascular endothelial growth factor (VEGF) is overexpressed in pancreatic cancer.Although VEGF has been shown to be a probable marker for poor prognosis, the concentration portal blood not yet clinically reported ductal adenocarcinoma (PDAC).The aim of study was measure VEGF-A patients with PDAC and evaluate its performance as prognostic marker.Material methods: Thirty-six consecutive out 57 operated on head lesion pathologically verified diagnosis were enrolled this study.We...
Nowadays, increasing attention has been focused on relation between increased D-dimer levels and cancer among patients without detectable thrombosis. The aim of the study was to measure plasma in portal peripheral blood pancreatic with absence venous thromboembolism.Fifteen consecutive hospitalized Department General Transplant Surgery Medical University Łódź, from January March 2012 who underwent surgery due a were enrolled. At laparotomy, sampled concurrently. fibrinogen measured....
Background: MicroRNAs (miRNAs) are small RNA molecules involved in the control of expression many genes and responsible for, among other things, cell death, differentiation their division. Changes miRNA profiles have been observed colorectal cancer. This discovery significantly enriches our knowledge pathogenesis cancer offers new goals diagnostics therapy. Aim: The aim this study was to analyze four sequences—miR-143, miR-1, miR-210 let-7e—and investigate significance risk developing...
This single center prospective cohort study evaluated the influence of hemihepatectomy on glucose homeostasis.The included 30 patients undergoing hemihepatectomy. All underwent an oral 75 g tolerance test before (baseline), 1 week and month after surgery. Plasma glucose, insulin glucagon were measured in OGTT samples, HOMA index was calculated. The fasting levels interleukin 6 1β, tumor necrosis factor adiponectin assessed.The plasma 120-min post-challenge mean level increased during from...
Preclinical evidence suggests that T4 can promote tumor growth while T3 act conversely; therefore, the fT3 and fT4 concentrations should affect overall survival (OS) in cancer patients. The objective of study was to look for an association between thyroid hormone peripheral blood OS pancreatic adenocarcinoma (PDAC) patients group. We included, retrospectively, 15 PDAC patients, without dysfunction under treatment, who underwent radical surgery, with no prior history anticancer therapy. TSH,...