A5067423176- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Diabetes and associated disorders
- Ophthalmology and Eye Disorders
- Dialysis and Renal Disease Management
- Social Issues in Poland
- Estrogen and related hormone effects
- Bariatric Surgery and Outcomes
- Cervical Cancer and HPV Research
- Inflammatory mediators and NSAID effects
- Central European Literary Studies
- Human Health and Disease
- Bone health and treatments
- Education and Cultural Studies
- Labour Market and Migration
- Hedgehog Signaling Pathway Studies
- Vascular anomalies and interventions
- Children's Physical and Motor Development
- Potassium and Related Disorders
- Tuberous Sclerosis Complex Research
- Genomic variations and chromosomal abnormalities
- Sarcoidosis and Beryllium Toxicity Research
Medical University of Lodz
2011-2024
Polish Mother’s Memorial Hospital Research Institute
2006-2024
Uniwersytecki Szpital Dziecięcy
2020
Kazimierz Wielki University in Bydgoszcz
2015-2019
University of Warsaw
1971
The cyclooxygenases are a group of enzymes catalyzing the formation prostaglandins from arachidonic acid. Cyclooxygenase-1 (COX-1) is constitutive form, thought to be "housekeeping gene", with constant levels expression in most tissues. COX-1 thyroid gland, except for medullary carcinoma, has not been subject much interest. Cyclooxygenase-2 (COX-2) can expressed response various stimuli, such as mitogens, hormones, cytokines, growth factors. product COX-2 activity implicated carcinogenesis....
Recent studies have shown that the phosphatidylinositol 3-kinase (PI3K) signaling pathway is important regulator of many cellular events, including apoptosis, proliferation and motility. PI3K alterations (PIK3CA gene mutations and/or amplification) been observed in various human tumours. In majority diagnosed cases, are localized one three "hot spots" gene, responsible for coding catalytic subunit α class I (PIK3CA). Mutations amplification PIK3CA characteristic thyroid cancer, as well.The...
RET/PTC rearrangements are the most frequent molecular changes in papillary thyroid carcinoma (PTC). So far, 15 main have been described, among which RET/PTC1 and RET/PTC3 common PTC - especially radiation-induced tumours. result of intrachromosomal paracentric inversions chromosome 10, where RET activating genes (H4 ELE1, respectively) located. Recently, shown not only but also benign lesions, including Hashimoto's thyroiditis (HT). The aim study was an assessment patients with...
In 1997 a currently obligatory model of iodine prophylaxis, based on mandatory iodization household salt with 30 mg KI/kg, was introduced. The aim our study to assess the intake among school-age children living in Opoczno 3 subsequent time points - 1994, before establishment operating 1999 2 years after implementation prophylaxis and 2010, 14 its implementation.We assessed goitre incidence urine concentration (UIC) 104 207 174 2012. Age examined ranged from 6 15 years. thyroid volumes...
This single center prospective cohort study evaluated the influence of hemihepatectomy on glucose homeostasis.The included 30 patients undergoing hemihepatectomy. All underwent an oral 75 g tolerance test before (baseline), 1 week and month after surgery. Plasma glucose, insulin glucagon were measured in OGTT samples, HOMA index was calculated. The fasting levels interleukin 6 1β, tumor necrosis factor adiponectin assessed.The plasma 120-min post-challenge mean level increased during from...
COX-2 is an enzyme isoform that catalyses the formation of prostanoids from arachidonic acid. An increased gene expression believed to participate in carcinogenesis. Recent studies have shown up-regulation associated with development numerous neoplasms, including skin, colorectal, breast, lung, stomach, pancreas and liver cancers. products stimulate endothelial cell proliferation their overexpression has been demonstrated be involved mechanism decreased resistance apoptosis. Suppressed...
Due to the mild-to-moderate iodine deficiency in Poland, 1997 prophylaxis based on obligatory salt iodization was introduced. We attempted evaluate effectiveness of such prophylaxis, over 20 years observations supply school-aged children Opoczno district (Central Poland).A group 603 (316 girls and 287 boys), aged 6-14, examined at 4 time points: 1994, 1999, 2010 2016. The were tested for urine concentration (UIC) each child thyroid volume measured ultrasonographically.The median UIC 1994...
The aim of the study was to evaluate distribution blood dendritic cells (DCs) in patients with Graves’ orbitopathy (GO) and assess influence methylprednisolone therapy on subsets peripheral mononuclear (PBMCs). Peripheral DC were analyzed by flow cytometry active GO ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>n</mi> <mo>=</mo> <mn>17</mn> </math> ), inactive id="M2"> <mn>8</mn> disease (GD) without id="M3"> ) controls id="M4"> <mn>15</mn> ); additionally, id="M5">...
An assessment of the risk Graves’ orbitopathy (GO) is an important challenge in disease (GD) management. The purpose this study was to compare non-genetic parameters GD patients with and without GO order find novel factors verify already reported. A total number 161 people, 70 91 non-GO were included study. confirmed be associated smoking, older age, higher TSH receptor antibodies (TRAb) lower thyroglobulin antibody (TgAb) levels hypercholesterolemia. We demonstrated latter correlation even...
Abstract Background Genetic background of Riedel's thyroiditis remains unknown. Herein, we describe our results studies on genes expression levels in thyroiditis. Case report and genetic findings We the case 48-year old woman with who has presented unusual course disease non-specific cervical discomfort, though as no pain and/or compression symptoms. After surgery, thyroid specimens were quantitatively evaluated, regarding PIK3CA, PIK3CD, PIK3CG, Tg, TGFB1, THRB, COL1, CDKN1C, CDH3 CACNA2D2...
De novo balanced chromosomal aberrations (BCAs), such as reciprocal translocations and inversions, are genomic that, in approximately 25% of cases, affect the human phenotype. Delineation exact structure BCAs may provide a precise diagnosis and/or point to new disease loci. We report on six patients with de (BCTs) one patient inversion, whom we mapped breakpoints resolution 1 bp, using shallow whole-genome mate pair sequencing. In all seven disruption at least gene was found. two patients,...
The risk of neoplastic transformation in patients with chronic thyroiditis (Hashimoto's - HT) is slightly increased. Genetic background this observation still unclear. PI3K isoforms are linked inflammatory and processes, thus they appear to be interesting subjects a research respect. aim our study was assess the PIK3CA, PIK3CB, PIK3CD PIK3CG genes expression levels HT.Following conventional cytological examination, 67 thyroid FNAB specimens, received from HT, were quantitatively evaluated...
SUMMARY The recombination between the methA alleles of Aspergillus nidulans is very strongly polarized. mutants can be mapped in respect to each other and flanking markers, both on basis relative frequency one P classes R classes. In all crosses it distal mutant which converts predominantly. combination crossed low temperature at meiosis proceeded increased modified pattern.
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Fc receptor-like (FCRL) genes play a role in the immune system by encoding proteins that function as receptors on surface of cells. The clinical significance FCRL gene expression Graves' Disease (GD) and Orbitopathy (GO) remains unclear. We evaluated 2, 3, 4 mRNA patients with GD GO its development activity these diseases.
The direct effect of TSH on bone metabolism in vivo is difficult to capture as the changes its concentrations are followed by respective alterations thyroid hormone levels. We evaluated recombinant human (rhTSH) sclerostin and other markers 29 patients after total thyroidectomy for differentiated cancer (DTC), without any signs disease recurrence, who received L-thyroxine, most at non-suppressive doses. For two consecutive days, were administered a standard dose 0.9 mg rhTSH, i.m....