A5109284305- Hormonal Regulation and Hypertension
- Renal and Vascular Pathologies
- Blood Pressure and Hypertension Studies
- Adrenal and Paraganglionic Tumors
- Abdominal vascular conditions and treatments
- Pituitary Gland Disorders and Treatments
- Obstructive Sleep Apnea Research
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Cancer, Hypoxia, and Metabolism
- Sleep and related disorders
- Cerebrovascular and Carotid Artery Diseases
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Vascular Anomalies and Treatments
- Adrenal Hormones and Disorders
- Nutrition and Health Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Circadian rhythm and melatonin
- Neuroblastoma Research and Treatments
- Cancer, Lipids, and Metabolism
Institute of Cardiology
2014-2025
University of Padua
2025
Azienda Ospedaliera di Padova
2025
Jagiellonian University
2016-2024
Rigshospitalet
2023
Cardinal Stefan Wyszyński University in Warsaw
2023
Instytut Matki i Dziecka
2021
Hypertension Institute
2017-2020
Medical University of Warsaw
2002-2016
National Center for Tuberculosis and Lung Disease
2016
Percutaneous renal sympathetic denervation by radiofrequency energy has been reported to reduce blood pressure (BP) the reduction of efferent and afferent signaling. We evaluated effects this procedure on BP sleep apnea severity in patients with resistant hypertension apnea. studied 10 refractory (7 men 3 women; median age: 49.5 years) who underwent completed 3-month 6-month follow-up evaluations, including polysomnography selected chemistries, measurements. Antihypertensive regimens were...
It has been postulated that catheter-based renal denervation (RDN) may lower blood pressure (BP) and improve severity of obstructive sleep apnea (OSA) in resistant hypertensive patients. The aim our study (NCT01366625) was to investigate a prospective randomized trial the effect RDN on BP clinical course OSA. Sixty patients with true hypertension coexisting moderate-to-severe OSA (apnea/hypopnea index, ≥15) were randomly allocated group (30 patients) control patients). primary end point...
Arterial hypertension is a major cardiovascular risk factor. Identification of secondary in its various forms key to preventing and targeting treatment complications. Simplified diagnostic tests are urgently required distinguish primary address the current underdiagnosis latter.This study uses Machine Learning (ML) classify subtypes endocrine (EHT) large cohort hypertensive patients using multidimensional omics analysis plasma urine samples. We measured 409 multi-omics (MOmics) features...
Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, glucokinase activator (GKA) lead that we have previously disclosed, caused reversible hepatic lipidosis in repeat-dose toxicology studies. We hypothesized the was due structure-based toxicity and later established it formation of thiourea metabolite, 2. Subsequent SAR studies 1 led identification pyrazine-based analogue 3, lacking thiazole moiety. In vivo metabolite studies,...
Abstract BACKGROUND Inflammation plays a pivotal role in blood pressure regulation. Current data reflect the important of T cells primary hypertension. The dendritic (DC) secondary hypertension- aldosteronism (PA) remains unknown. aim this study was to quantify peripheral lymphocytes, plasmacytoid (pDCs) and inflammatory markers individuals with PA comparing essential hypertension (HTN). METHODS 39 patients 15 HTN were enrolled. Clinical data, serum aldosterone concentration, ambulatory...
Abstract Objective Hypertension is a major cardiovascular risk factor affecting about 1 in 3 adults. Although the majority of hypertension cases (∼90%) are classified as ‘primary hypertension’ (PHT), endocrine (EHT) accounts for ∼10% and caused by underlying conditions such primary aldosteronism (PA), Cushing's syndrome (CS), pheochromocytoma or paraganglioma (PPGL). EHT often misdiagnosed PHT leading to delays treatment condition, reduced quality life costly, ineffective, antihypertensive...
The aim of our study was to evaluate renal resistive index (RI) value in never treated hypertensive patients relation ambulatory blood pressure measurement (ABPM) values and early target organ damage. included 318 subjects: 223 with essential hypertension (mean age 37.1 years) 95 normotensive healthy subjects 37.9 years). ABPM, echocardiography carotid arteries duplex color Doppler examinations were performed. RI no different from the control group (0.59 ± 0.05 vs 0.59 0.05; NS). In...
Nonadherence to antihypertensive therapy is one of the main causes resistant hypertension.The aim our study was evaluate adherence in patients with hypertension by determining serum drug levels use liquid chromatography-tandem mass spectrometry (LC-MS/MS).The included 36 primary selected from RESIST-POL (23 men and 13 women; mean age, 52.5 ±9.1 years; range, 22-67 number drugs, 5.3 ±1.4), who met all 3 inclusion criteria: ≥4 drugs; average daytime ambulatory systolic blood pressure ≥140...
Fibromuscular dysplasia (FMD), regarded as a generalized vascular disease, may affect all beds and result in arterial stenosis, occlusion, aneurysm, or dissection. It has been proposed to systematically evaluate patients with FMD, regardless of initial FMD involvement. However, the impact this approach on clinical decisions management is unknown. Within prospective ARCADIA-POL study (Assessment Renal Cervical Artery Dysplasia–Poland), we evaluated 232 lesions confirmed at least one bed, out...
Introduction: The aim of this study was to evaluate in patients with resistant hypertension (RHTN) enrolled the RESIST-POL relationship between primary aldosteronism (PA) and obstructive sleep apnoea (OSA) their effect on metabolic abnormalities cardiac structure. Material methods: We included 204 (123 M, 81 F, mean age 48.4 yrs) true RHTN, eGFR > 60 mL/min/1,73 m2 no known diabetes. OSA defined as an apnoea/hypopnoea index 15/h or more. Metabolic syndrome components were assessed. On...
Introduction. Insomnia may increase risk of cardiovascular events. There is little data available reporting the prevalence and clinical relevance insomnia in patients with essential hypertension. Therefore, aim study was to investigate relationship between different biochemical parameters hypertension patients. Methods. Four hundred thirty‐two (mean age: 47±13 years; 253 male, 179 female) were screened for using Athens Scale (AIS). Several variables including age, sex, known duration...
Patients with resistant hypertension (RHT) are at high risk for coronary artery disease (CAD) and cerebrovascular (CVD), compared the general hypertensive population. The aim of study was to evaluate factors associated RHT in a large sample patients under care practitioners specialists Poland. We included 12 375 (mean age, 64.0 ±12.3 years; age range, 18-98 women, 59%) treated least 1 year. were divided into 3 groups: controlled hypertension, uncontrolled (not fulfilling criteria RHT), RHT....
Objective: To provide a comprehensive assessment of left ventricle (LV) structure, and function to detect alterations in cardiac properties relationship presence, subtypes extent fibromuscular dysplasia (FMD). Methods: We studied 144 patients with FMD. The control group consisted 50 matched individuals. Office ambulatory blood pressure levels were evaluated. Echocardiography was employed assess: ventricular mass index (LVMI), systolic including speckle tracking echocardiography diastolic...
It has been suggested that there might be a pathophysiological link and overlap between primary aldosteronism (PA) obstructive sleep apnea (OSA). Therefore, in prospective study, we evaluated the frequency of PA hypertensive patients suspected having OSA.We included 207 consecutive (mean age 53.2 ± 12.1 years, 133 M, 74 F) referred for polysomnography on basis one or more following clinical features: typical OSA symptoms, resistant difficult-to-treat hypertension, diabetes, cardiovascular...
Background: Increased ultrasound Doppler renal resistive index (RRI) is a marker of atherosclerotic and hypertensive organ damage both at systemic level. Aim: To evaluate RRI in patients with true resistant hypertension (TRHT) the RESIST-POL study. Methods: From 204 diagnosed TRHT study, 151 (90 male, 61 female, mean age: 47.7 ± 10.4, range: 19–65 years) without secondary were included into analysis. All characterised by estimated glomerular filtration rate > 60 mL/min/1.73 m2 no history...
Human heart rate is moderated by the autonomous nervous system acting predominantly through sinus node (the main cardiac physiological pacemaker). One of dominant factors that determine in conditions its coupling with respiratory rhythm. Using language stochastic processes, we analyzed both rhythms simultaneously taking data from polysomnographic recordings two healthy individuals. Each rhythm was treated as a sum deterministic drift term and diffusion (Kramers-Moyal expansion). We found...
Background. Clinical benefit from renal artery revascularization remains controversial, probably because of inaccurate stenosis severity assessment. Objective. The aim the study was to evaluate resting translesional pressures ratio and fractional flow reserve (rFFR) in relation angiography Doppler duplex ultrasonography patients with at least moderate (RAS). Methods. 44 hypertensive (48% males, mean age 65 years) RAS were investigated. Translesional systolic pressure gradient (TSPG), Pd/Pa...
<b><i>Aims:</i></b> The aim of this study was to assess the usefulness somatostatin receptor scintigraphy (SRS) using <sup>99m</sup>Tc-[HYNIC, Tyr3]-octreotide (TOC) and <sup>123</sup>I-metaiodobenzylguanidine (mIBG) in patients with <i>SDHx</i>-related syndromes which paragangliomas were detected by computed tomography establish an optimal imaging diagnostic algorithm <i>SDHx</i> mutation carriers....