A5062071364- Cardiac Imaging and Diagnostics
- Gene expression and cancer classification
- Coronary Interventions and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Acute Myocardial Infarction Research
- Erythropoietin and Anemia Treatment
- Hormonal Regulation and Hypertension
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Renin-Angiotensin System Studies
- Innovations in Medical Education
- Cardiovascular Disease and Adiposity
- Neurological Disease Mechanisms and Treatments
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Atrial Fibrillation Management and Outcomes
- Cancer Genomics and Diagnostics
- Genetic Mapping and Diversity in Plants and Animals
- Simulation-Based Education in Healthcare
- Angiogenesis and VEGF in Cancer
University of Glasgow
2016-2025
Paris Cardiovascular Research Center
2025
Université Paris Cité
2025
Inserm
2025
King Saud University
2024
British Heart Foundation
2008-2023
Golden Jubilee National Hospital
2011-2017
University of Dundee
2012-2016
Imaging Center
2016
National Institute for Health Research
2016
MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to control protein production through binding "seed" sequences within a target mRNA. Each miRNA is capable of potentially controlling hundreds genes. The regulation miRNAs in lung during development pulmonary arterial hypertension (PAH) unknown.We screened profiles longitudinal and crossover design PAH caused by chronic hypoxia or monocrotaline rats. We identified reduced expression Dicer, involved processing, onset after...
Despite improved understanding of the underlying genetics, pulmonary arterial hypertension (PAH) remains a severe disease. Extensive remodeling small arteries, including proliferation artery smooth muscle cells (PASMCs), characterizes PAH. MicroRNAs (miRNAs) are noncoding RNAs that have been shown to play role in vascular remodeling.We assessed miR-145 PAH.We localized mouse lung muscle. Using quantitative PCR, we demonstrated increased expression wild-type mice exposed hypoxia. PAH was...
The pathogenesis of pulmonary arterial hypertension (PAH) remains unclear. 4 microRNAs representing the miR-143 and miR-145 stem loops are genomically clustered.To elucidate transcriptional regulation miR-143/145 cluster role in PAH.We identified promoter region that regulates microRNA expression artery smooth muscle cells (PASMCs). We mapped PAH-related signaling pathways, including estrogen receptor, liver X factor/retinoic transforming growth factor-β (Smads), hypoxia (hypoxia response...
Abstract Aims A fractional flow reserve (FFR) value ≥0.90 after percutaneous coronary intervention (PCI) is associated with a reduced risk of adverse cardiovascular events. TARGET-FFR an investigator-initiated, single-centre, randomized controlled trial to determine the feasibility and efficacy post-PCI FFR-guided optimization strategy vs. standard angiography in achieving final FFR values ≥0.90. Methods results After angiographically guided PCI, patients were 1:1 receive physiology-guided...
Background— Pulmonary arterial hypertension (PAH) is a hyperproliferative vascular disorder observed predominantly in women. Estrogen potent mitogen human pulmonary artery smooth muscle cells and contributes to PAH vivo; however, the mechanisms attributed this causation remain obscure. Curiously, heightened expression of estrogen-metabolizing enzyme cytochrome P450 1B1 (CYP1B1) reported idiopathic murine models PAH. Methods Results— Here, we investigated putative pathogenic role CYP1B1...
Despite the increasing importance of long noncoding RNA in physiology and disease, their role endothelial biology remains poorly understood. Growing evidence has highlighted them to be essential regulators human embryonic stem cell differentiation. SENCR, a vascular-enriched RNA, overlaps Friend Leukemia Integration virus 1 (FLI1) gene, regulator development. Therefore, we wanted test hypothesis that SENCR may contribute mesodermal commitment as well function. We thus developed new...
Renal tubulointerstitial fibrosis is the common end point of progressive renal disease. MicroRNA (miR)-214 and miR-21 are upregulated in models injury, but function miR-214 this setting effect its manipulation remain unknown. We assessed inhibiting an animal model fibrosis. In mice, genetic deletion significantly attenuated interstitial induced by unilateral ureteral obstruction (UUO). Treatment wild-type mice with anti-miR directed against (anti-miR-214) before UUO resulted similar...
Owing to the dynamic nature of transcriptome, gene expression profiling is a promising tool for discovery disease-related genes and biological pathways. In present study, we examined in whole blood 12 patients with CAD (coronary artery disease) healthy control subjects. Furthermore, ten underwent whole-blood analysis before after completion cardiac rehabilitation programme following surgical coronary revascularization. mRNA miRNA (microRNA) were isolated profiling. Gene identified 365...
The use of fractional flow reserve in patients with non-ST-segment-elevation myocardial infarction (NSTEMI) is a controversial issue. We undertook study to assess the vasodilatory capacity coronary microcirculation NSTEMI when compared model preserved (stable angina [SA] cohort: culprit and nonculprit vessel) acute microcirculatory dysfunction (ST-segment-elevation [STEMI] cohort). hypothesized that response would be NSTEMI.A total 140 undergoing single vessel percutaneous intervention were...
ABSTRACT The pathophysiological mechanism of increased fractures in young adults with type 1 diabetes mellitus (T1DM) is unclear. We conducted a case-control study trabecular bone microarchitecture and vertebral marrow adiposity women T1DM. Thirty T1DM median age (range) 22.0 years (16.9, 36.1) attending one outpatient clinic at diagnosis 9.7 (0.46, 14.8) were compared 28 age-matched healthy who acted as controls. Measurements included MRI-based assessment proximal tibial volume/total volume...
Drug-eluting stents reduce the incidence of in-stent restenosis, but they result in delayed arterial healing and are associated with a chronic inflammatory response hypersensitivity reactions. Identifying novel interventions to enhance wound may improve long-term clinical outcomes. Micro-ribonucleic acids (miRNAs) noncoding small ribonucleic that play prominent role initiation resolution inflammation after vascular injury.This study sought identify miRNA regulation function implantation...
Arterial hypertension is a major cardiovascular risk factor. Identification of secondary in its various forms key to preventing and targeting treatment complications. Simplified diagnostic tests are urgently required distinguish primary address the current underdiagnosis latter.This study uses Machine Learning (ML) classify subtypes endocrine (EHT) large cohort hypertensive patients using multidimensional omics analysis plasma urine samples. We measured 409 multi-omics (MOmics) features...
Background Vascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents, but associated with cancer therapy-related cardiac dysfunction (CTRCD) and hypertension. The timing, frequency magnitude of these toxicities poorly defined. objective this study is therefore to investigate the incidence, time course mechanisms VEGFI-associated CTRCD Methods Patients commencing VEGFI underwent blood pressure (BP) monitoring, echocardiography biomarker measurement at baseline...
T2-Weighted MRI reveals myocardial edema and enables estimation of the ischemic area at risk salvage in patients with acute infarction (MI). We compared diagnostic accuracy a new bright-blood T2-weighted standard black blood MI.A breath-hold, T2-weighted, Acquisition for Cardiac Unified T2 Edema pulse sequence normalization coil sensitivity breath-hold dark-blood short tau inversion recovery were used to depict 54 consecutive MI patients. Infarct size was measured on gadolinium late contrast...
MicroRNAs (miRNAs) are short noncoding RNAs, which post-transcriptionally regulate gene expression. miRNAs transcribed as precursors and matured to active forms by a series of enzymes, including Dicer. important in governing cell differentiation, development, disease. We have recently developed feeder- serum-free protocol for direct derivation endothelial cells (ECs) from human embryonic stem (hESCs) provided evidence increases angiogenesis-associated (miR-126 -210) during the process....
Primary aldosteronism (PA) is common and associates with excess cardiovascular morbidity independent of blood pressure. Exposure to aldosterone sodium leads cardiac fibrosis hypertrophy in humans animals possibly mediated by inflammation oxidative stress. We aimed clarify the effects on myocardial structure composition human subjects PA essential hypertension using contrast-enhanced magnetic resonance imaging as well explore mechanistic basis for any observed differences.Twenty-seven...
Background— Distal coronary to aortic pressure ratio (Pd/Pa) and instantaneous wave-free (iFR) are indices of functional significance a stenosis measured without hyperemia. It has been suggested that iFR superior diagnostic accuracy Pd/Pa when compared with fractional flow reserve (FFR). We hypothesized in comparison FFR, revascularization decisions based on either binary cutoff values for or hybrid strategies incorporating will result similar levels disagreement. Methods Results— This is...
Purpose To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T 1 relaxation time distribution, and global native between sexes across age groups. Materials Methods In all, 84 volunteers underwent MRI 1.5T 3.0T. maps were acquired in three left ventricular short axis slices using an optimized modified Look–Locker inversion recovery investigational prototype sequence. measurements msec calculated from 16...
Rationale: Endothelial-to-mesenchymal transition (EndMT) is a dynamic biological process involved in pathological vascular remodeling. However, the molecular mechanisms that govern this remain largely unknown, including contribution of long noncoding RNAs (lncRNAs). Objectives: To investigate role lncRNAs EndMT and their relevance to Methods Results: study vitro, primary endothelial cells were treated with transforming growth factor-β2 interleukin-1β. Single-cell bulk RNA-seq...