A5080817425- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Lymphoma Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Chronic Lymphocytic Leukemia Research
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Smoking Behavior and Cessation
- Viral-associated cancers and disorders
- Transplantation: Methods and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Antimicrobial Resistance in Staphylococcus
- Retinal Imaging and Analysis
- Blood Pressure and Hypertension Studies
- CNS Lymphoma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Chronic Disease Management Strategies
- Aortic Disease and Treatment Approaches
St Vincent's Hospital
2013-2024
Department of Health and Human Services
2024
Martinsburg VA Medical Center
2024
Yale University
2024
University of California, Los Angeles
2019-2024
Michigan State University
2024
University of Virginia
2024
Medical University of South Carolina
2024
VA Greater Los Angeles Healthcare System
2019-2023
University of Minnesota
2021-2023
L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. supplementation improves vascular reactivity and functional capacity in peripheral arterial disease (PAD) small, short-term studies. We aimed to determine effects long-term administration on patients with PAD.The Nitric Oxide Peripheral Arterial Insufficiency (NO-PAIN) study was a randomized clinical trial oral (3 g/d) versus placebo for 6 months 133 subjects intermittent claudication due PAD...
Background— Peripheral arterial disease (PAD) is common but commonly unrecognized. Improved recognition of PAD needed. We used high-throughput proteomic profiling to find PAD-associated biomarkers. Methods and Results— Plasma was collected from patients (ankle brachial index <0.90; n=45) subjects with risk factors without (n=43). analyzed surface-enhanced laser desorption/ionization time-of-flight mass spectrometry quantify 1619 protein peaks. The peak intensity a 12-kDa higher in...
The prognosis of HIV-infected patients with non-Hodgkin lymphoma in the highly active antiretroviral therapy (HAART) era approaches that general population when they are treated same protocols. We analyzed outcome Hodgkin (HL) doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) HAART according to HIV serostatus establish whether this also holds true for HL.From 1997 2010, 224 newly diagnosed HL, whom 93 were positive, consecutively ABVD chemotherapy. HIV-positive had more high-risk...
Purpose The immune microenvironment is key to the pathophysiology of classical Hodgkin lymphoma (CHL). Twenty percent patients experience failure their initial treatment, and others receive excessively toxic treatment. Prognostic scores biomarkers have yet influence outcomes significantly. Previous biomarker studies been limited by extent tissue analyzed, statistical inconsistencies, validate findings. We aimed overcome these limitations validating recently identified (CD68, FOXP3, CD20) in...
The use of fractional flow reserve in patients with non-ST-segment-elevation myocardial infarction (NSTEMI) is a controversial issue. We undertook study to assess the vasodilatory capacity coronary microcirculation NSTEMI when compared model preserved (stable angina [SA] cohort: culprit and nonculprit vessel) acute microcirculatory dysfunction (ST-segment-elevation [STEMI] cohort). hypothesized that response would be NSTEMI.A total 140 undergoing single vessel percutaneous intervention were...
Abstract Purpose: The opportunity to improve therapeutic choices on the basis of molecular features tumor cells is horizon in diffuse large B-cell lymphoma (DLBCL). Agents such as bortezomib exhibit selective activity against poor outcome activated type (ABC) DLBCL. In order for targeted therapies succeed this disease, robust strategies that segregate patients into groups with high reliability are needed. Although studies considered gold standard, several immunohistochemistry (IHC)...
Overuse is considered to be a main causative factor for tendinopathies; however, recent reports indicate that tendinopathy also common among both overweight and inactive individuals. These factors are associated with abdominal obesity, dyslipidemia, hypertension, insulin resistance. We hypothesized these features would tendinopathy.To compare lipid profile between participants Achilles matched controls.Fasting serum lipids were measured 60 chronic painful midportion (54% male) control...
To compare the outcome of patients diagnosed with HIV infection and diffuse large B-cell lymphoma (DLBCL) treated R-CHOP in cART era that a HIV-negative control group.From 2003 to 2011, 305 (97 HIV-positive) were DLBCL R-CHOP. Clinical features compared using chi-square or Fisher's exact test. Survival analysis was performed Kaplan-Meier method log-rank Multivariate Cox regression proportional hazards model.HIV-positive had more B symptoms extranodal sites disease at diagnosis, but...
Gene expression studies have identified the microenvironment as a prognostic player in diffuse large B-cell lymphoma. However, there is lack of simple immune biomarkers that can be applied clinical setting and could helpful stratifying patients. Immunohistochemistry has been used for this purpose but results are inconsistent. We decided to reinvestigate its impact using immunohistochemistry, with two systems image analysis, set patients Diagnostic tissue from 309 was arrayed onto...
Peripheral arterial disease (PAD) is associated with major cardiovascular morbidity and mortality. Abnormalities in nitric oxide metabolism due to excess of the NO synthase inhibitor asymmetric dimethylarginine (ADMA) may be pathogenic PAD. We explored association between ADMA levels markers atherosclerosis, function, prognosis. A total 133 patients symptomatic PAD were enrolled. Ankle—brachial index (ABI), walking time, vascular function measures (arterial compliance flow-mediated...
The purpose of this study was to analyze antinuclear antibody (ANA) screening by enzyme-linked immunosorbent assay (ELISA) followed indirect fluorescent (IFA) testing confirm and characterize the pattern titer antibody. We evaluated 4 ANA ELISAs 1 HEp-2 IFA substrate in 224 clinically defined serum samples consisting 30 from systemic lupus erythematosus (SLE) cases, 94 rheumatoid arthritis 100 healthy donors plus 495 submitted for routine 12 reference distributed Centers Disease Control...
An increasing number of arterial function assessments are available, including small and large elasticity (SAE/C2, LAE/C1), endothelial as measured by flow mediated dilation (FMD), carotid intima–medial thickness (IMT), ankle brachial index (ABI), pulse pressure (PP), wave velocity (PWV). We have consecutively performed these measures in subjects with low high vascular disease risks to assess the interrelationships. Twenty healthy (HS) 20 older type 2 diabetes mellitus (DM) were studied all...
Peripheral arterial disease (PAD) is common, but often not diagnosed. A biomarker index would be useful to raise suspicion of PAD, so as trigger appropriate vascular testing and management. The study comprised 540 individuals: 197 individuals with both coronary artery peripheral (CAD + PAD); 81 CAD only; 262 no hemodynamically significant (NHSD) the or arteries. Multiple linear regression was performed generate a panel score that could predict ankle-brachial (ABI). Logistic used investigate...
The relationship between epicardial stenosis and microvascular resistance remains controversial. Exploring the is critical, as many tools used in interventional cardiology imply minimal constant resistance. However, variable collateralization may impact well on these measures. We hypothesized that when collateral supply was accounted for, would be independent of stenosis.Forty patients with stable angina were studied before following percutaneous intervention. A temperature pressure sensing...