A5010782903- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Palliative Care and End-of-Life Issues
- Brain Metastases and Treatment
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Childhood Cancer Survivors' Quality of Life
- Pleural and Pulmonary Diseases
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Tumors and Oncological Cases
- Occupational and environmental lung diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- BRCA gene mutations in cancer
- Family Support in Illness
- Cancer survivorship and care
- Cancer Treatment and Pharmacology
- Vascular Tumors and Angiosarcomas
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Grief, Bereavement, and Mental Health
- Breast Lesions and Carcinomas
Dana-Farber Cancer Institute
2016-2025
Massachusetts General Hospital
2011-2024
Harvard University
2015-2024
Dana-Farber/Harvard Cancer Center
2024
Boston University
2021-2024
Cancer Institute (WIA)
2024
Boston Children's Hospital
2024
Stanford University
2024
University Hospital Waterford
2023
Beth Israel Deaconess Medical Center
2022
Preterm delivery remains the leading cause of perinatal mortality. Risk factors and biomarkers have traditionally failed to identify majority preterm deliveries.To develop validate a mass spectrometry-based serum test predict spontaneous in asymptomatic pregnant women.A total 5501 women were enrolled between 17(0/7) 28(6/7) weeks gestational age prospective Proteomic Assessment study at 11 sites United States 2011 2013. Maternal blood was collected enrollment outcomes following delivery....
Activating mutations or structural rearrangements in BRAF are identified roughly 75% of all pediatric low-grade astrocytomas (PLGAs). However, first-generation RAF inhibitors approved for adult melanoma have poor blood-brain penetrance and only effective on tumors that express the canonical BRAFV600E oncoprotein, which functions as a monomer. These drugs (type I antagonists target "DFG-in" conformation kinase) fail to block signaling via KIAA1549:BRAF, truncation/fusion oncoprotein dimer is...
Abstract Purpose: Eribulin modulates the tumor-immune microenvironment via cGAS-STING signaling in preclinical models. This non-randomized phase II trial evaluated combination of eribulin and pembrolizumab patients with soft-tissue sarcomas (STS). Patients Methods: enrolled one three cohorts: leiomyosarcoma (LMS), liposarcomas (LPS), or other STS that may benefit from PD-1 inhibitors, including undifferentiated pleomorphic sarcoma (UPS). was administered at 1.4 mg/m2 i.v. (days 1 8)...
Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLCs, ∼12% all cases, uniquely dependent on POU2F3 itself; as such, approaches to attenuate expression may represent new therapeutic opportunities. Here using genome-scale screens for regulators SCLC proliferation, we define mSWI/SNF complexes top dependencies specific SCLC. Notably, chemical disruption ATPase activity...
We hypothesize that recurrence following pleurectomy decortication (PD) is primarily local. explored factors associated with tumor patterns, disease-free interval (DFI), and post-recurrence survival (PRS). Tumor a major barrier for long-term after pleural mesothelioma (PM) surgery. All patients who underwent PD between 1998 2022 were identified. Patients diffuse PM achieved macroscopic complete resection had sufficient information on relapse included. Postoperative scans reviewed to...
Purpose Secondary acute myeloid leukemia (sAML), defined as AML arising after a prior myelodysplastic syndrome or antineoplastic therapy, responds poorly to current therapies. It is often associated with adverse karyotypic abnormalities and overexpression of proteins that mediate drug resistance. We performed phase III trial determine whether induction therapy cytarabine amonafide L-malate, DNA intercalator non–ATP-dependent topoisomerase II inhibitor evades resistance mechanisms, yielded...
Gene expression studies have identified the microenvironment as a prognostic player in diffuse large B-cell lymphoma. However, there is lack of simple immune biomarkers that can be applied clinical setting and could helpful stratifying patients. Immunohistochemistry has been used for this purpose but results are inconsistent. We decided to reinvestigate its impact using immunohistochemistry, with two systems image analysis, set patients Diagnostic tissue from 309 was arrayed onto...
Abstract Background Tumor recurrence remains the main barrier to survival after surgery for pleural mesothelioma (PM). Soluble mesothelin‐related protein (SMRP) and cancer antigen 125 (CA‐125) are established blood‐based biomarkers monitoring PM. We prospectively studied utility of these pleurectomy decortication (PD). Methods Patients who underwent PD achieved complete macroscopic resection with available preoperative SMRP levels were included. marker determined within 60 days three...
The purpose of this secondary analysis was to characterize the reliability, validity, and minimally clinically important difference (MCID) change scores over time European Organisation for Research Treatment Cancer Quality Life Questionnaire-CIPN-20 item (QLQ-CIPN20) in young adults receiving paclitaxel or vincristine. Fifty vincristine treatment cancer completed QLQ-CIPN20 at three points associated with increasing cumulative chemotherapy dose. Subject Significance Questionnaire T3....
Treatment decision-making in adolescents and young adults (AYAs) requires preference consideration tradeoffs. Using MyPref, an adaptive conjoint analysis tool, we examined compared the treatment preferences of both AYAs their parent or other trusted person (PTP). aged 15-30 with advanced cancer independently completed including demographic questions, Control Preference Scale, survey. could invite a PTP to participate. Participants received personalized MyPref Summary Report quantifying for...
We report a series of 355 consecutive patients treated over 9 years in single institution with intended PDC.Surgery for MPM has shifted from extra-pleural pneumonectomy to PDC the goal MCR.Clinical and outcome data were reviewed. Kaplan-Meier estimators log rank test used compare overall survival, logistic regression models used.MCR was achieved 304. There 223 males, median age 69 histology epithelioid 184. The 30 90-day mortality 3.0% 4.6%.Most complications low grade. Prolonged air leak...