A5034844578- Cancer survivorship and care
- Cancer-related cognitive impairment studies
- Childhood Cancer Survivors' Quality of Life
- Statistical Methods and Inference
- Brain Metastases and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods and Bayesian Inference
- Palliative Care and End-of-Life Issues
- Glioma Diagnosis and Treatment
- Bayesian Methods and Mixture Models
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Acute Myeloid Leukemia Research
- Frailty in Older Adults
- Family Support in Illness
- Physical Activity and Health
- Histone Deacetylase Inhibitors Research
- Health Literacy and Information Accessibility
- Peptidase Inhibition and Analysis
- Family and Disability Support Research
- Chromatin Remodeling and Cancer
- Head and Neck Cancer Studies
- Neutropenia and Cancer Infections
- Social Media in Health Education
- Renal cell carcinoma treatment
University of North Carolina at Chapel Hill
2021-2025
UNC Lineberger Comprehensive Cancer Center
2021-2025
Dana-Farber Cancer Institute
2024-2025
Mayo Clinic
2015
University of Minnesota
2014
To evaluate the safety and efficacy of gemcitabine cisplatin in combination with immune checkpoint inhibitor pembrolizumab as neoadjuvant therapy before radical cystectomy (RC) muscle-invasive bladder cancer.
Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLCs, ∼12% all cases, uniquely dependent on POU2F3 itself; as such, approaches to attenuate expression may represent new therapeutic opportunities. Here using genome-scale screens for regulators SCLC proliferation, we define mSWI/SNF complexes top dependencies specific SCLC. Notably, chemical disruption ATPase activity...
Patients with locally advanced head and neck squamous cell cancer (HNSCC) are treated surgery followed by adjuvant (chemo) radiotherapy or definitive chemoradiation, but recurrence rates high. Immune checkpoint blockade improves survival in patients recurrent/metastatic HNSCC; however, the role of chemo-immunotherapy curative setting is not established.This phase 2, single-arm, multicenter study evaluated neoadjuvant carboplatin, nab-paclitaxel, durvalumab resectable HNSCC. The primary end...
Identifying and characterizing relationships between treatments, exposures, or other covariates time-to-event outcomes has great significance in a wide range of biomedical settings. In research areas such as multi-center clinical trials, recurrent events, genetic studies, proportional hazard mixed effects models (PHMMs) are used to account for correlations observed clusters within the data. high dimensions, proper specification fixed random PHMMs is difficult computationally complex. this...
While the enthusiasm for artificial intelligence (AI) to enhance surgical decision-making continues grow, preceding advance of risk prediction tools (RPTs) has had limited impact date. To help inform development AI-powered tools, we evaluated role RPTs and prevailing attitudes among urologists. We conducted a national mixed methods study using sequential explanatory design. Through 2019 AUA Census, surveyed urologists on RPT use, helpfulness, trust. Based responses, interviewed 25...
The lifetime incidence of kidney stones is about two times greater in men compared to women. Extracellular vesicles (EVs) shed from activated cells are present the urine and may reflect or even mediate renal physiology and/or pathology. This study was designed standardize methodology characterize urinary EVs by digital flow cytometry identify possible sex differences persons with without their first symptomatic stones.Twenty-four-hour collections were obtained presenting stone episode (n =...
Abstract Background Physical inactivity is common in young adult cancer survivors (YACS), but evidence regarding effects of physical activity (PA) interventions among YACS limited. The IMproving Activity after Cancer Treatment (IMPACT) trial evaluated a theory‐based mobile PA intervention on total minutes/week (primary) and secondary outcomes (moderate‐to‐vigorous [MVPA], light PA, steps, sedentary behaviors) at 6 months YACS. Methods ( N = 280) were randomized to an group or self‐help...
Abstract Background Young adult cancer survivors experience early aging‐related morbidities and mortality. Biological aging biomarkers may identify at‐risk increase our understanding of mechanisms underlying this accelerated aging. Methods Using an observational study design, we cross‐sectionally measured DNA methylation‐based epigenetic age in young at a tertiary, academic state hospital. Participants were convenience sample consecutively enrolled childhood, adolescent, cancers treated with...
Generalized linear mixed models (GLMMs) are widely used in research for their ability to model correlated outcomes with non-Gaussian conditional distributions. The proper selection of fixed and random effects is a critical part the modeling process since misspecification may lead significant bias. However, joint has historically been limited lower-dimensional GLMMs, largely due use criterion-based strategies. Here we present R package glmmPen, one first select higher dimension using...
Treatment options for human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases (BCBMs) remain limited. We previously reported central nervous system (CNS) activity neratinib and neratinib-capecitabine. Preclinical data suggest that may overcome resistance to ado-trastuzumab emtansine (T-DM1) when given in combination. In Translational Breast Cancer Research Consortium (TBCRC) 022's cohort 4, we examined the efficacy of plus T-DM1 patients with HER2-positive BCBM.
Cognitive difficulties have been described after chemotherapy for breast cancer, but there is no standard of care to improve cognitive outcomes in these patients. This trial examined the feasibility, tolerability, acceptability, and preliminary effects memantine prevent decline during cancer.Patients with stage I-III scheduled neo/adjuvant chemotherapy, completed a battery prior 4 weeks completing chemotherapy. Memantine (10 mg BID) was administered concurrent Our primary outcome visual...
Background Young adult cancer survivors experience frailty and decreased muscle mass at rates equivalent to much older noncancer populations, which indicate accelerated aging. Although low can be identified in survivors, their implications for health‐related quality of life are not well understood. Methods Through a cross‐sectional analysis young was assessed with the Fried phenotype skeletal relation functional outcomes measured by Medical Outcomes Survey Short‐Form 36 (SF‐36). z tests...
Chimeric antigen receptor (CAR)-T cells targeting CD30 have demonstrated high response rates with durable remissions observed in a subset of patients relapsed/refractory CD30+ hematologic malignancies, particularly classical Hodgkin lymphoma. This therapy has low toxicity including cytokine release syndrome no neurotoxicity our phase 2 study. We collected patient-reported outcomes (PROs) on treated directed CAR-T to evaluate the impact this their symptom experience. PROs PROMIS...
Abstract Small cell lung cancers (SCLC) are comprised of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLC, ∼12% all cases, uniquely dependent on POU2F3 itself; as such, approaches to attenuate expression may represent new therapeutic opportunities. Here using genome-scale screens for regulators SCLC proliferation, we define mSWI/SNF complexes, non-canonical BAF (ncBAF) top dependencies specific SCLC. Notably,...
Abstract OBJECTIVES To compare oncologic outcomes after segmentectomy with division of segmental bronchus, artery and vein (complete anatomic segmentectomy) versus <3 structures (incomplete segmentectomy). METHODS We conducted a single-centre, retrospective analysis patients undergoing from March 2005 to May 2020. Operative reports were audited classify procedures as complete or incomplete segmentectomy. Patients who underwent neoadjuvant therapy pulmonary resection beyond indicated...
ABSTRACT Modern biomedical datasets are increasingly high-dimensional and exhibit complex correlation structures. Generalized linear mixed models (GLMMs) have long been employed to account for such dependencies. However, proper specification of the fixed random effects in GLMMs is difficult high dimensions, computational complexity grows with increasing dimension effects. We present a novel reformulation GLMM using factor model decomposition effects, enabling scalable computation dimensions...
Ibrutinib is an oral Bruton's tyrosine kinase inhibitor approved for treatment of chronic lymphocytic leukemia (CLL) and small lymphoma (SLL). Clinical trial data suggest that strict adherence directly related to clinical outcomes. This retrospective, multicenter study aimed evaluate ibrutinib its impact on outcomes in patients with CLL/SLL treated the real-world setting. The primary outcome was quantify rates setting using proportion days covered (PDC) calculation. Secondary included...
Abstract Objective Electronic health records (EHRs) have become widely adopted with increasing emphasis on improving care delivery. Improvements in surgery may be limited by specialty-specific issues that impact EHR usability and engagement. Accordingly, we examined use perceptions urology, a diverse surgical specialty. Methods We conducted national, sequential explanatory mixed methods study. Through the 2019 American Urological Association Census, surveyed urologic surgeons then identified...
Abstract Background Most physical activity (PA) interventions in young adult cancer survivors (YACS) have focused on short‐term outcomes without evaluating longer‐term and PA maintenance. This study examined the effects of an mHealth intervention at 12 months, after 6 months tapered contacts, relative to a self‐help group among 280 YACS. Methods YACS participated 12‐month randomized trial that compared groups. All participants received tracker, smart scale, individual videochat session,...
Abstract Importance The COVID‐19 pandemic led to reductions in primary care and cancer screening visits, which may delay detection of some cancers. impact on incidence has not been fully quantified. We examined change determine how the have altered characteristics cancers diagnosed among women. Methods This study included female patients aged ≥18 years with breast ( n = 9489), colon 958), pancreatic 669), or uterine 1991) at three hospitals North Carolina. Using interrupted time series, we...