A5103241775- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Pharmacogenetics and Drug Metabolism
- Lung Cancer Research Studies
- Eicosanoids and Hypertension Pharmacology
- Corneal Surgery and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Gout, Hyperuricemia, Uric Acid
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Animal Virus Infections Studies
- Neurological Disease Mechanisms and Treatments
- Peptidase Inhibition and Analysis
- Plant biochemistry and biosynthesis
- Heavy Metals in Plants
- Lung Cancer Treatments and Mutations
- Retinal Imaging and Analysis
- Rice Cultivation and Yield Improvement
- Phytochemistry and Biological Activities
- Gut microbiota and health
- Acute Ischemic Stroke Management
- Healthcare and Venom Research
Capital Medical University
2024-2025
Hebei University of Chinese Medicine
2024-2025
Wenzhou Medical University
2023-2025
Beijing Friendship Hospital
2024-2025
Zhejiang Cancer Hospital
2025
Zhejiang University
2022-2025
Hebei Medical University
2023-2024
Harbin Medical University
2020-2024
Harvard University
2024
Sichuan University
2022-2024
Vascular remodeling plays a vital role in hypertensive diseases and is an important target for hypertension treatment.Irisin, newly discovered myokine adipokine, has been found to have beneficial effects on various cardiovascular diseases.However, the pharmacological effect of irisin antagonizing hypertension-induced vascular not well understood.In present study, we investigated protection mechanisms against induced by angiotensin II (Ang II).Adult male mice wild-type, FNDC5...
Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLCs, ∼12% all cases, uniquely dependent on POU2F3 itself; as such, approaches to attenuate expression may represent new therapeutic opportunities. Here using genome-scale screens for regulators SCLC proliferation, we define mSWI/SNF complexes top dependencies specific SCLC. Notably, chemical disruption ATPase activity...
Methylmercury (MeHg) is a global environmental pollutant with neurotoxicity, which can easily crosses the blood–brain barrier and cause irreversible damage to human central nervous system (CNS). CNS inflammation autophagy are known be involved in pathology of neurodegenerative diseases. Meanwhile, MeHg has potential induce microglia-mediated neuroinflammation as well autophagy. This study aims further explore exact molecular mechanism neurotoxicity. We conducted vitro studies using BV2...
Rapid restoration of corneal epithelium integrity after injury is particularly important for preserving transparency and vision. Mesenchymal stem cells (MSCs) can be taken into account as the promising regenerative therapeutics improvement wound healing processes based on variety effective components. The extracellular vesicles form MSCs, especially exosomes, have been considered paracrine mediators though transferring microRNAs recipient cell. This study investigated mechanism human...
Induced pluripotent stem cells and mesenchymal are that represent promising therapies for treating various tissue injuries wound healing. Exosomes nanosized extracellular vesicles have been identified as important mediators of therapeutic functions, which performed via cell communication. In this study, we compared the efficacy induced cells-derived exosomes (iPSCs-Exos) (MSCs-Exos) in corneal epithelial defects. The characteristics two types were not significantly different. Compared to...
Pseudomonas aeruginosa (P. aeruginosa) keratitis, a worldwide leading cause of corneal perforation and blindness, which is associated with contact lens usage. Increasing evidence has indicated that pyroptosis, novel proinflammatory programmed cell death, linked ocular diseases, little known about the role noncanonical pyroptosis in microbial keratitis. Here, we first involvement P. keratitis investigated whether wedelolactone (WDL), major active component Eclipta prostrate to target...
Abstract SXT/R391 integrative and conjugative elements (ICEs) are self-transmissible mobile genetic that found in most members of Enterobacteriaceae . Here, we determined fifteen ICEs carried by Proteus isolates from food (4.2%) diarrhoea patients (17.3%). BLASTn searches against GenBank showed the were closely related to different species, including mirabilis Using core gene phylogenetic analysis, grouped into six distinct clusters, a dominant cluster three clusters have not been previously...
Floral fragrance is one of the most important characteristics ornamental plants and plays a pivotal role in plant lifespan such as pollinator attraction, pest repelling, protection against abiotic biotic stresses. However, precise determination floral limited. In present study, volatile compounds six Hedychium accessions exhibiting from faint to highly fragrant were comparatively analyzed via gas chromatography–mass spectrometry (GC–MS) Electronic nose (E-nose). A total 42 identified through...
Silica nanoparticles (SiNPs) have been widely used in food, cosmetics, medicine and other fields; however, there growing concerns regarding their potential adverse effects on health. A large number of studies confirmed that SiNPs with small particle diameters can pass through the blood brain barrier, causing irreversible damage to nervous system. This study aims further explore molecular mechanism neurotoxicity provide a toxicological basis for medical application SiNPs.We conducted an vitro...
Based on the theory of "Gongsun (SP4) connects Thoroughfare Vessel" "eight confluence acupoints", effect electroacupuncture (EA) at SP4 Kelch-like epichlorohydrin associated protein factor 1 (Keap1)/ nuclear factor-erythroid 2 related (Nrf2)/ heme oxygenase-1 (HO-1) signaling pathway was observed in rats with premature ovarian insufficiency (POI) for exploring its underlying mechanisms treating POI. Thirty-two female SD were randomly divided into 4 groups:blank, model, EA and medication, 8...
ABSTRACT Attaching/effacing (A/E) pathogens induce DNA damage and colorectal cancer by injecting effector proteins into host cells via the type III secretion system (T3SS). EspF is one of T3SS-dependent exclusive to A/E pathogens, which include enterohemorrhagic Escherichia coli . The role in induction double-strand breaks (DSBs) phosphorylation repair protein SMC1 has been demonstrated previously. However, process accumulation DSB formation remained enigmatic, response not well understood....
Liver injury and progressive liver failure are severe life-threatening complications in sepsis, further worsening the disease leading to death. Macrophages their mediated inflammatory cytokine storm critical regulators occurrence progression of for which effective treatments still lacking. l-Ascorbic acid 6-palmitate (L-AP), a food additive, can inhibit neuroinflammation by modulating phenotype microglia, but its pharmacological action septic damage has not been fully explored. We aimed...
The triglyceride-glucose (TyG) index has been recommended as a practical surrogate of insulin resistance (IR). However, the association between TyG and hyperuricemia among adults with hypertension remains to be elucidated. We included analyzed 3134 HTN patients 4233 non-HTN participants from cross-sectional 2013-2018 U.S. National Health Nutrition Examination Surveys (NHANES). Multivariable logistic regression restricted cubic splines (RCS) were used explore hyperuricemia. Stratifed analyses...
The yield potential of japonica/indica hybrids (JIH) has been achieved over 13.5 t ha−1 in large-scale rice fields, and some physiological traits for advantage JIH japonica inbred (JI) indica hybrid (IH) were also identified. To date, little attention paid to morphological JI IH. For this reason, three JIH, JI, IH field-grown at East China (Ningbo, Zhejiang Province) 2015 2016. Compared with IH, had 14.3 20.8% higher grain yield, respectively, attributed its more spikelets per panicle...
Changes in secretory immunoglobulin A (SIgA) coated bacteria from early to late pregnancy were associated with the development of gestational diabetes mellitus (GDM). SIgA beneficial gut bacteria, which are depleted GDM, potential probiotics for prevention GDM. We investigated blood biochemistry, chronic inflammation, mucosal barrier biomarkers and faecal microbiota healthy (T1H, n = 50), (T3H, 30) women GDM (T3D, 27). The "leaky gut" markers, zonulin lipopolysaccharide (LPS), significantly...
Diabetic retinopathy is the most common microvascular complication of diabetes; however, early changes in retinal microvessels are difficult to detect clinically, and a patient's vision may have begun deteriorate by time problem identified. Optical coherence tomography angiography (OCTA) an innovative tool for observing capillaries vivo. The aim this study was analyze vessel density thickness patients with diabetes.This retrospective, observational cross-sectional study. Between August 2018...