A5004722731- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac and Coronary Surgery Techniques
- Advanced MRI Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Emergency and Acute Care Studies
- Coronary Artery Anomalies
- Cardiac Ischemia and Reperfusion
- Cardiovascular Disease and Adiposity
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
Catharina Ziekenhuis
2016-2025
Radboud University Nijmegen
2016-2025
Eindhoven University of Technology
2011-2025
Fujita Health University
2023
University of Sheffield
2022
Stanford University
2010-2021
VA Palo Alto Health Care System
2021
Center for Clinical Research (United States)
2021
McMaster University
2019
KLE Society Hospital
2018
In patients with multivessel coronary artery disease who are undergoing percutaneous intervention (PCI), angiography is the standard method for guiding placement of stent. It unclear whether routine measurement fractional flow reserve (FFR; ratio maximal blood in a stenotic to normal flow), addition angiography, improves outcomes.In 20 medical centers United States and Europe, we randomly assigned 1005 undergo PCI implantation drug-eluting stents guided by alone or FFR measurements...
The preferred initial treatment for patients with stable coronary artery disease is the best available medical therapy. We hypothesized that in functionally significant stenoses, as determined by measurement of fractional flow reserve (FFR), percutaneous intervention (PCI) plus therapy would be superior to alone.In whom PCI was being considered, we assessed all stenoses measuring FFR. Patients at least one stenosis (FFR, ≤0.80) were randomly assigned FFR-guided (PCI group) or alone...
We hypothesized that in patients with stable coronary artery disease and stenosis, percutaneous intervention (PCI) performed on the basis of fractional flow reserve (FFR) would be superior to medical therapy.In 1220 disease, we assessed FFR all stenoses were visible angiography. Patients who had at least one stenosis an 0.80 or less randomly assigned undergo FFR-guided PCI plus therapy receive alone. whom more than received alone included a registry. The primary end point was composite death...
We hypothesized that fractional flow reserve (FFR)–guided percutaneous coronary intervention (PCI) would be superior to medical therapy as initial treatment in patients with stable artery disease.
The appropriate duration of dual antiplatelet therapy in patients at high risk for bleeding after the implantation a drug-eluting coronary stent remains unclear.
The Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) study demonstrated significantly improved health outcomes at 1 year in patients randomized to multivessel percutaneous coronary intervention guided by fractional flow reserve (FFR) compared with angiography alone. economic impact of routine measurement FFR this setting is not known.In study, 1005 were randomly assigned FFR-guided or angiography-guided and followed up year. A prospective cost-utility analysis...
Patients with three-vessel coronary artery disease have been found to better outcomes coronary-artery bypass grafting (CABG) than percutaneous intervention (PCI), but studies in which PCI is guided by measurement of fractional flow reserve (FFR) lacking.
Background: Previous studies found that percutaneous coronary intervention (PCI) does not improve outcome compared with medical therapy (MT) in patients stable artery disease, but PCI was guided by angiography alone. FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) fractional flow reserve best MT disease to assess clinical outcomes and cost-effectiveness. Methods: A total of 888 single-vessel or multivessel reduced were randomly assigned plus (n=447) alone...
Our aim was to determine whether use of the filter-based Sentinel™ Cerebral Protection System (CPS) during transcatheter aortic valve implantation (TAVI) can affect early incidence new brain lesions, as assessed by diffusion-weighted magnetic resonance imaging (DW-MRI), and neurocognitive performance.From January 2013 July 2015, 65 patients were randomised 1:1 transfemoral TAVI with or without Sentinel CPS. Patients underwent DW-MRI extensive neurological examination, including testing one...
Background— The predictive value of fractional flow reserve (FFR) measured immediately after percutaneous coronary intervention (PCI) with drug-eluting stent placement has not been prospectively investigated. We investigated the potential post-PCI FFR measurements to predict clinical outcome in patients from FAME 1 and 2 trials (Fractional Flow Reserve or Angiography for Multivessel Evaluation). Methods Results— All who had measurement were included. primary was vessel-oriented composite end...
Randomized data comparing outcomes of transcatheter aortic valve replacement (TAVR) with surgery in low–surgical risk patients at time points beyond 2 years is limited. This presents an unknown for physicians striving to educate as part a shared decision-making process. The authors evaluated 3-year clinical and echocardiographic from the Evolut Low Risk trial. Low-risk were randomized TAVR self-expanding, supra-annular or surgery. primary endpoint all-cause mortality disabling stroke several...