Martina Rothenbühler
A5053528722- Acute Myocardial Infarction Research
- Streptococcal Infections and Treatments
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Vascular Procedures and Complications
- Heart Rate Variability and Autonomic Control
- Diabetes Management and Research
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- High Altitude and Hypoxia
- Pharmaceutical studies and practices
- Preterm Birth and Chorioamnionitis
- Atrial Fibrillation Management and Outcomes
- Pancreatic function and diabetes
- Thermoregulation and physiological responses
- Phonocardiography and Auscultation Techniques
- COVID-19 epidemiological studies
- Analytical Chemistry and Chromatography
- Cardiovascular Effects of Exercise
- Long-Term Effects of COVID-19
- COVID-19 impact on air quality
- Antimicrobial Resistance in Staphylococcus
- Stress Responses and Cortisol
- Advanced Chemical Sensor Technologies
University of Bern
2014-2024
University Hospital of Bern
2021-2024
Swiss Continence Foundation
2024
University of Toronto
2020
Western University
2020
3M (United States)
2020
St. Michael's Hospital
2020
St Michaels Hospital
2020
Bühler (United Kingdom)
2020
Institute of Social and Preventive Medicine
2014-2019
We hypothesized that fractional flow reserve (FFR)–guided percutaneous coronary intervention (PCI) would be superior to medical therapy as initial treatment in patients with stable artery disease.
Conflicting evidence exists on the efficacy and safety of bivalirudin administered as part percutaneous coronary intervention (PCI) in patients with an acute syndrome.We randomly assigned 7213 syndrome for whom PCI was anticipated to receive either or unfractionated heparin. Patients group were subsequently not a post-PCI infusion. Primary outcomes comparison between heparin occurrence major adverse cardiovascular events (a composite death, myocardial infarction, stroke) net clinical...
<h3>BACKGROUND:</h3> It is unclear whether seasonal changes, school closures or other public health interventions will result in a slowdown of the current coronavirus disease 2019 (COVID-19) pandemic. We aimed to determine epidemic growth globally associated with climate intended reduce transmission severe acute respiratory syndrome 2 (SARS-CoV-2). <h3>METHODS:</h3> performed prospective cohort study all 144 geopolitical areas worldwide (375 609 cases) at least 10 COVID-19 cases and local by...
Comparing the performance of different continuous glucose monitoring (CGM) systems is challenging due to lack comprehensive guidelines for clinical study design. In particular, absence concise requirements distribution comparator (reference) blood (BG) concentrations and their rate change (RoC) that are used evaluate CGM performance, impairs comparability. For this article, several experts in field testing have collaborated propose characteristics measurements should be collected during...
Background As a daily point measurement, basal body temperature (BBT) might not be able to capture the shift in menstrual cycle because single measurement is present on sliding scale of circadian rhythm. Wrist skin measured continuously during sleep has potential overcome this limitation. Objective This study compares diagnostic accuracy these two temperatures for detecting ovulation and investigate correlation agreement between describing thermal changes cycles. Methods prospective included...
To test the optimal antithrombotic regimen in patients with acute coronary syndrome. Randomised controlled trial. Patients syndrome and without ST segment elevation 78 centres Italy, Netherlands, Spain, Sweden. 7213 planned percutaneous intervention: 4010 3203 elevation. The primary study results overall population have been reported previously. were randomly assigned, an open label fashion, to one of two regimens: bivalirudin glycoprotein IIb/IIIa inhibitors restricted procedural...
Aims To assess whether radial compared with femoral access is associated consistent outcomes in patients ST-segment elevation myocardial infarction (STEMI) and non-ST-segment acute coronary syndrome (NSTE-ACS). Methods results In the Minimizing Adverse Haemorrhagic Events by TRansradial Access Site Systemic Implementation of angioX (MATRIX) programme were randomized to or access, stratified STEMI (2001 radial, 2009 femoral) NSTE-ACS (2196 2198 femoral). The 30-day co-primary major adverse...
<h3>Importance</h3> Although rheumatic heart disease has been nearly eradicated in high-income countries, 3 4 children grow up parts of the world where it is still endemic. <h3>Objectives</h3> To determine prevalence clinically silent and manifest as a function age, sex, socioeconomic status to estimate age-specific incidence. <h3>Design, Setting, Participants</h3> In this school-based cross-sectional study with cluster sampling, 26 schools Sunsari district Eastern Nepal 5467 eligible 5 15...
Multivalvular disease is of increasing concern in elderly patients undergoing transcatheter aortic valve replacement (TAVR). The objective the present analysis was to investigate impact concomitant mitral stenosis (MS) on clinical outcomes TAVR for severe, symptomatic (AS).Among 1339 between August 2007 and December 2015, adequate echocardiographic data assessment severity aetiology MS available 971 (72.5%) patients. Patients were stratified according degree MS. Mitral documented 176 (18.1%)...
Objectives We investigated machinelearningbased identification of presymptomatic COVID-19 and detection infection-related changes in physiology using a wearable device. Design Interim analysis prospective cohort study. Setting, participants interventions Participants from national study Liechtenstein were included. Nightly they wore the Ava-bracelet that measured respiratory rate (RR), heart (HR), HR variability (HRV), wrist-skin temperature (WST) skin perfusion. SARS-CoV-2 infection was...
Importance Arterial hypoxemia, electrolyte imbalances, and periodic breathing increase the vulnerability to cardiac arrhythmia at altitude. Objective To explore incidence of tachyarrhythmias bradyarrhythmias in healthy individuals high altitudes. Design, Setting, Participants This prospective cohort study involved altitude (8849 m) on Mount Everest, Nepal. Recruitment occurred from January 25 May 9, 2023, data analysis took place June July 2023. Exposure All participants underwent 12-lead...
Background: In continuous glucose monitoring (CGM) system performance studies, it is common to implement specific procedures for manipulating the participants’ blood (BG) levels during collection of comparator BG measurements. Recently, such a procedure was proposed by group experts, and this study assessed its ability produce combinations rates change (RoCs) with certain characteristics. Methods: During three separate in-clinic sessions conducted over 15 days, capillary measurements were...
Echocardiographic screening allows for early detection of subclinical stages rheumatic heart disease among children in endemic regions.To investigate the effectiveness systematic echocardiographic combination with secondary antibiotic prophylaxis on prevalence disease.This cluster randomized clinical trial included students 9 to 16 years age attending public and private schools urban rural areas Sunsari district Nepal that had been randomly selected November 17, 2012. follow-up was performed...
<h3>Objective</h3> To assess long-term clinical outcomes of consecutive high-risk patients with severe aortic stenosis according to treatment allocation transcatheter valve implantation (TAVI), surgical replacement (SAVR) or medical (MT). <h3>Methods</h3> Patients were consecutively enrolled into a prospective single centre registry. <h3>Results</h3> Among 442 (median age 83 years, median STS-score 4.7) allocated MT (n=78), SAVR (n=107), TAVI (n=257) all-cause mortality amounted 81%, 37% and...
In the Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX (MATRIX) trial, adults with acute coronary syndrome undergoing intervention who were allocated to radial access had a lower risk bleeding, kidney injury (AKI), all-cause mortality, as compared those femoral access. The mechanism mortality benefit remained unclear.We used multistate competing models determine effects on AKI in MATRIX trial disentangle relationship between these...