A5039137581- Streptococcal Infections and Treatments
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Infective Endocarditis Diagnosis and Management
- Drug-Induced Hepatotoxicity and Protection
- Ethnobotanical and Medicinal Plants Studies
- Phytochemistry and Bioactive Compounds
- Hibiscus Plant Research Studies
- Diverse Scientific Research Studies
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Antimicrobial Resistance in Staphylococcus
- Asthma and respiratory diseases
- Phonocardiography and Auscultation Techniques
- Flavonoids in Medical Research
- Advances in Cucurbitaceae Research
- Silymarin and Mushroom Poisoning
- Phytochemistry and Bioactivity Studies
- Computational Drug Discovery Methods
- Phytochemistry and Biological Activities
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- Heart Rate Variability and Autonomic Control
- Food Science and Nutritional Studies
- Phytochemistry and biological activity of medicinal plants
Dr. A.P.J. Abdul Kalam Technical University
2024
GLA University
2021-2024
College of Medical Sciences
2013-2023
Universal College of Medical Sciences
2013-2023
Indian Institute of Technology Ropar
2023
Dr. Bhim Rao Ambedkar University
1988-2022
B.P. Koirala Institute of Health Sciences
2010-2022
Nepal Medical College Teaching Hospital
2018
Lilavati Hospital & Research Centre
2017
Universal College
2015
<h3>Importance</h3> Although rheumatic heart disease has been nearly eradicated in high-income countries, 3 4 children grow up parts of the world where it is still endemic. <h3>Objectives</h3> To determine prevalence clinically silent and manifest as a function age, sex, socioeconomic status to estimate age-specific incidence. <h3>Design, Setting, Participants</h3> In this school-based cross-sectional study with cluster sampling, 26 schools Sunsari district Eastern Nepal 5467 eligible 5 15...
Echocardiographic screening allows for early detection of subclinical stages rheumatic heart disease among children in endemic regions.To investigate the effectiveness systematic echocardiographic combination with secondary antibiotic prophylaxis on prevalence disease.This cluster randomized clinical trial included students 9 to 16 years age attending public and private schools urban rural areas Sunsari district Nepal that had been randomly selected November 17, 2012. follow-up was performed...
Background Fluoroquinolones are the most commonly used group of antimicrobials for treatment enteric fever, but no direct comparison between two fluoroquinolones has been performed in a large randomised trial. An open-label randomized trial was conducted to investigate whether gatifloxacin is more effective than ofloxacin uncomplicated fever caused by nalidixic acid-resistant Salmonella enterica serovars Typhi and Paratyphi A. Methodology Principal Findings Adults children clinically...
Abstract Context Wolfram syndrome (WFS) is a rare autosomal recessive disorder characterized by juvenile-onset diabetes, diabetes insipidus, optic atrophy, deafness, and progressive neurodegeneration. However, due to the nature of disease lack complete clinical manifestations, confirmed diagnosis WFS at time onset challenge. Objective With WFS1 heterozygous variants reported in there need for comprehensive genetic screening strategies early delineating phenotypic spectrum associated with...
Cassia fistula (CF) is known as Aragvadha (disease killer) in Ayurvedic classics and its sun-dried (SD) fruit pulp has been advocated for the treatment of constipation, fever, leprosy, diabetes, intestinal disorders wounds. Present study includes evaluation SD non-sun dried (NSD) CF purgative action rat acute toxicity mouse. Aqueous suspension NSD were administered orally 60 min before experiment rats just mice. Both dose 1.0 g/kg showed an increase number defecations fecal output during 4...
Background: Flavonoids are plant-derived chemicals found naturally in various parts of plants. They an important component a broad range nutraceuticals because their antimutagenic, antibacterial, anti-inflammatory, and antioxidative properties. Tangeretin, example the flavone class flavonoid compounds, is tangerine other citrus fruit peels. It natural constituent with vast pharmacological activities extensively numerous fruits or juices. Objective: The goal study was to gather information on...
Introduction: In developing countries like Nepal, iron deficiency anemia (IDA) is one of the major concern. The high rate incidence has been related to insufficient intake, accompanied by chronic intestinal blood loss due parasitic and malarial infections. Therefore, a study was conducted evaluate prevalence IDA in anemic patients Universal College Medical Sciences-Teaching Hospital (UCMS-TH), South Western region, Nepal.
 Material Method It hospital based cross sectional comprised 100...
Accidental mushroom poisoning is constantly seen and regularly reported from all over world. Exact magnitude of problem its clinical profile in Nepal not well known. This study was done to evaluate treatment outcome patients presenting with the department internal medicine, BPKIHS, Dharan.It a prospective observational conducted Dharan 1st January 2008 31st December 2009. Informed consent taken. All were subjected necessary laboratory investigation. They followed up at 1 week month after...
Pregnancy is accompanied by profound alterations in the thyroid economy and relative iodine deficiency. The median Urinary Iodine Excretion (UIE) most reliable indicator of population's nutrition. physiological normal pregnancy, such as an increased glomerular filtration rate, potentially invalidate UIE assessment tool pregnancy.To assess pregnant mothers to enquire about current status their iodised salt intake.We carried out a cross-sectional study which urine samples were collected from...
Drug-induced hypersensitivity reaction is of great clinical significance in therapeutics. The objective this reporting two cases to show that anaphylaxis can occur with pantoprazole.A 38-year-old female reported the emergency ward a critical condition, history periorbital edema, edema skin, pruritus, nausea, vomiting, and difficulty breathing 20 minutes after ingestion pantoprazole 40 mg tablet. A 32-year-old complaints rashes all over body, itching on whole swollen lips eyes tablet.It...
Introduction: D-dimer is currently the best available marker for COVID-19 associated hemostatic abnormalities. This study aims to find out prevelance of elevated levels in confirmed cases intensive care unit a tertiary hospital western Nepal.
 Methods: descriptive cross-sectional was conducted among 95 patients admitted COVID Intensive Care Unit teriary centre from August 2020 January 2021 after taking ethical clearence Institutional Review Committee order determine cases. value...
The study was planned to investigate the anti-urolithiatic activity of fresh juice Citrus limon L. fruit. phytochemical screening also undertaken reveal alkaloids, flavonoids, reducing sugar, vitamin C, amino acid and sterols present in sample. Macromolecule supersaturation higher molecular weight components plant extract exerts its action similar natural urinary inhibitors inhibits crystal aggregation growth. Pharmacological evaluation performed by percentage dissolution turbidity method....
Objective: Plants are extremely useful as a source of medication. Calotropis procera is plant that used to treat variety illnesses in traditional medical and folklore systems. In this work, bioassay guided liquid-liquid fractionation, phytochemical molecular spectroscopic analysis the antioxidant activity young leaves were evaluated. Methods: Bioassay-guided fractionation was carried out on basis polarity solvents UV, FTIR, LCMS profiling conducted by using standard methods. The DPPH...
One percent of persons over 65 years age suffer from Parkinson's disease, a neurological ailment marked by dopaminergic neurons in the nigrostriatal pathway gradually dying and being depleted striatum. Parkin PINK1 gene mutations, which are essential for mitophagy impair mitochondrial function, cause it. disease is linked to number motor impairment disorders, including bradykinesia, rigid muscles, tremor at rest, imbalance. Numerous signaling pathways, α-synuclein aggregation, lead...