A5088458633- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Dietary Effects on Health
- FOXO transcription factor regulation
- Reproductive Biology and Fertility
- Carbon and Quantum Dots Applications
- Plant nutrient uptake and metabolism
- Autophagy in Disease and Therapy
- Heavy metals in environment
- Gut microbiota and health
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- Welding Techniques and Residual Stresses
- Coal and Its By-products
- Probiotics and Fermented Foods
- Blood donation and transfusion practices
- Indian History and Philosophy
- Clay minerals and soil interactions
- Aluminum toxicity and tolerance in plants and animals
- Agricultural Practices and Plant Genetics
- Kidney Stones and Urolithiasis Treatments
- Advanced Photocatalysis Techniques
- Plant responses to elevated CO2
- Selenium in Biological Systems
National Institute of Food Technology Entrepreneurship and Management
2025
San Diego State University
2024
Discovery Institute
2017-2024
Sanford Burnham Prebys Medical Discovery Institute
2017-2024
Central Institute of Medicinal and Aromatic Plants
2021-2024
Sri Sri University
2024
National Institute of Immunology
2014-2023
Academy of Scientific and Innovative Research
2021-2023
Salk Institute for Biological Studies
2017-2022
La Jolla Alcohol Research
2022
Abstract In this study, four biochars prepared from different crop residue waste i.e. sugarcane bagasse (SBB), coconut shell (CNB), paddy straw (PDB), and distilled of lemongrass (LGB) were evaluated for removal Remazol Brilliant Blue R the aqueous system. The RBBR adsorption capacities biochar 97–79% SBB, 99.9–99.47% CNB, 66.1–48% PDB, 78–68% LGB, dominantly controlled by their aromaticity mineral content. Langmuir Freundlich isotherms pseudo-second-order kinetic models have described...
The two-component system (TCS), which works on the principle of histidine-aspartate phosphorelay signaling, is known to play an important role in diverse physiological processes lower organisms and has recently emerged as signaling plants. Employing tools bioinformatics, we have characterized TCS candidate genes genome Oryza sativa L. subsp. japonica. We present a complete overview gene families O. sativa, including structures, conserved motifs, chromosome locations, phylogeny. Our analysis...
Summary Although dietary restriction ( DR ) is known to extend lifespan across species, from yeast mammals, the signalling events downstream of food/nutrient perception are not well understood. In C aenorhabditis elegans , typically attained either by using eat‐2 mutants that have reduced pharyngeal pumping leading lower food intake or feeding diluted bacterial worms. this study, we show knocking down a mammalian MEKK 3‐like kinase gene, mekk‐3 in . initiates process similar without...
The Human Microbiome Project was a research programme that successfully identified associations between microbial species and healthy or diseased individuals. However, major challenge the absence of model systems for studying host–microbiome interactions, which would increase our capacity to uncover molecular understand organ-specificity discover new microbiome-altering health interventions. Caenorhabditis elegans has been pioneering organism over 70 years but largely studied in microbiome....
Animals integrate changes in external and internal environments to generate behavior. While neural circuits detecting cues have been mapped, less is known about how states like hunger are integrated into behavioral outputs. Here, we use the nematode C . elegans examine nutritional status affect chemosensory behaviors. We show that acute food deprivation leads a reversible decline repellent, but not attractant, sensitivity. This change requires two conserved transcription factors MML-1...
Abstract Scaling up the synthesis of fluorescent silica nanoparticles to meet current demand in diverse applications involves technological limitations. The present study relates hydrothermal water-soluble, crystalline, blue-emitting amine-functionalized from coal fly ash sustainably and economically. This used tertiary amine (trimethylamine) prepare nanoparticles, enhancing fluorescence quantum yield nitrogen content for nanofertilizer application. TEM FESEM studies show that have a...
Abstract The metabolic state of an organism instructs gene expression modalities, leading to changes in complex life history traits, such as longevity. Dietary restriction (DR), which positively affects health and span across species, leads reprogramming that enhances utilisation fatty acids for energy generation. One direct consequence this shift is the upregulation cytoprotective (CyTP) genes categorized Gene Ontology (GO) term “Xenobiotic Detoxification Program” (XDP). How senses during...
// Neeraj Kumar 1,2 , Vaibhav Jain 1,* Anupama Singh Urmila Jagtap 1 Sonia Verma and Arnab Mukhopadhyay Molecular Aging Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India 2 Current address: Centre for Human Genetics Medicine, School Health Sciences Central University Punjab, Bathinda, * These authors have contributed equally to this work Correspondence to: Kumar, email: Mukhopadhyay, Keywords : DAF-16, FOXO, ChIP-seq, C. elegans, transcription, Gerotarget...
Two-component system (TCS) is one of the key signal sensing machinery which enables species to sense environmental stimuli. It essentially comprises three major components, sensory histidine kinase proteins (HKs), phosphotransfer (Hpts), and response regulator (RRs). The members TCS family have already been identified in Arabidopsis rice but knowledge about their functional indulgence during various abiotic stress conditions remains meager. Current study an attempt carry out comprehensive...
The molecular underpinnings of spinal cord injury (SCI) associated with neuropathic pain (NP) are unknown. Recent studies have demonstrated that matrix metalloproteinases (MMPs) such as MMP2 play a critical role in inducing NP following SCI. Promoter methylation MMPs is known to suppress their transcription and reduce NP. In this context, it has been shown rodents folic acid (FA), an FDA approved dietary supplement key methyl donor the central nervous system (CNS), increases axonal...
Contaminations of heavy metals such as lead (Pb) and cadmium (Cd) in medicinal plants (MPs) not only restrict their safe consumption due to health hazards but also lower productivity. Biochar amendments the soil are supposed immobilize toxic metals, improve quality agricultural However, impact biochar on growth attributes, metal accumulation, pharmacologically active compounds MPs, risk is less explored. An experiment was performed three (Bacopa monnieri (L.), Andrographis paniculata...
Insulin/IGF-1-like signalling (IIS) and dietary restriction (DR) are the two major modulatory pathways controlling longevity across species. Here, we show that both license a common chromatin modifier, ZFP-1/AF10. The downstream transcription factors of IIS select DR pathways, DAF-16/FOXO or PHA-4/FOXA, respectively, transcriptionally regulate expression zfp-1. ZFP-1, in turn, negatively regulates PHA-4/FOXA target genes, apparently forming feed-forward loops control amplitude as well...
Maintaining a healthy gut microbiome plays critical role in avoiding gut-related pathologies. Bacterial adherence to the intestinal epithelium vital niche establishment gut, as vitro experiments and mathematical modeling suggest that provides strong competitive advantage over free-floating planktonic microbes. Currently, we lack ability study an vivo model system. Through sampling natural populations of Caenorhabditis , discovered three bacterial species adhere several wild isolates. When...
The present study aims to evaluate differential ionomics and metabolic responses of genotypes (G1, G5, G6, G11) A. paniculata in mixed metal treatments. experiment was performed unary, binary, ternary treatments arsenic (As), cadmium (Cd), lead (Pb) taking four paniculata. interactive effect co-exposure metals on their accumulation, growth parameters, ionomics, metabolism different examined compared. Results revealed that binary were significantly than unary the mixture has an additive As...
Germ line integrity is crucial for progeny fitness. Organisms deploy the DNA damage response (DDR) signaling to protect germ from genotoxic stress, facilitating cell-cycle arrest of cells and repair or their apoptosis. Cell-autonomous regulation quality in well studied; however, how enforced cell non-autonomously on sensing somatic less known. Using Caenorhabditis elegans, we show that DDR disruption, only uterus, when insulin/IGF-1 (IIS) low, arrests oogenesis pachytene stage meiosis I, a...