A5057682900- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Aging, Elder Care, and Social Issues
- Sirtuins and Resveratrol in Medicine
Sanford Burnham Prebys Medical Discovery Institute
2022-2024
Discovery Institute
2024
A decline in macroautophagic/autophagic activity with age contributes to the accumulation of damaged molecules and is associated impairment neuronal functions onset age-related diseases, particularly neurodegenerative disorders. To learn about neuronal-specific roles autophagy genes aging, we specifically inhibited pan-neuronally
ABSTRACT While autophagy is key to maintain cellular homeostasis, tissue-specific roles of individual genes are less understood. To study neuronal in vivo , we inhibited specifically C. elegans neurons, and unexpectedly found that knockdown early-acting genes, i.e., involved formation the autophagosome, except for atg-16.2 decreased PolyQ aggregates increased lifespan, albeit independently degradation autophagosomal cargo. Neuronal can be secreted from neurons via vesicles called exophers,...