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Tatiana M. Moreno

ORCID: 0000-0002-7466-2491
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About
Contact & Profiles
A5065411172
Research Areas
  • Genetics, Aging, and Longevity in Model Organisms
  • Autophagy in Disease and Therapy
  • Endoplasmic Reticulum Stress and Disease
  • Aging, Elder Care, and Social Issues
  • Sirtuins and Resveratrol in Medicine

Sanford Burnham Prebys Medical Discovery Institute
 2022-2024

Discovery Institute
 2024

 Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons
OPENALEX - Publications 
Yongzhi Yang Meghan Lee Arnold Caitlin M. Lange Ling-Hsuan Sun Michael Broussalian and 9 more Saam Doroodian Hiroshi Ebata Elizabeth H. Choy Karie Poon Tatiana M. Moreno Anupama Singh Monica Driscoll Caroline Kumsta Malene Hansen

10.1038/s43587-023-00548-1 article EN Nature Aging 2024-01-04
 Inhibition of early-acting autophagy genes inC. elegansneurons improves protein homeostasis, promotes exopher production, and extends lifespan via the ATG-16.2 WD40 domain
OPENALEX - Publications 
Yongzhi Yang Meghan Lee Arnold Elizabeth H. Choy Caitlin M. Lange Karie Poon and 7 more Michael Broussalian Ling-Hsuan Sun Tatiana M. Moreno Anupama Singh Monica Driscoll Caroline Kumsta Malene Hansen

ABSTRACT While autophagy is key to maintain cellular homeostasis, tissue-specific roles of individual genes are less understood. To study neuronal in vivo , we inhibited specifically C. elegans neurons, and unexpectedly found that knockdown early-acting genes, i.e., involved formation the autophagosome, except for atg-16.2 decreased PolyQ aggregates increased lifespan, albeit independently degradation autophagosomal cargo. Neuronal can be secreted from neurons via vesicles called exophers,...

10.1101/2022.12.12.520171 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2022-12-14
 Transcriptional regulation of autophagy in aging
OPENALEX - Publications 
Tatiana M. Moreno Caitlin M. Lange Caroline Kumsta

10.1016/j.cophys.2022.100591 article EN Current Opinion in Physiology 2022-09-26
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