A5010562055- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- Aging, Elder Care, and Social Issues
- Endoplasmic Reticulum Stress and Disease
Buck Institute for Research on Aging
2022-2024
University of Southern California
2024
A decline in macroautophagic/autophagic activity with age contributes to the accumulation of damaged molecules and is associated impairment neuronal functions onset age-related diseases, particularly neurodegenerative disorders. To learn about neuronal-specific roles autophagy genes aging, we specifically inhibited pan-neuronally
ABSTRACT While autophagy is key to maintain cellular homeostasis, tissue-specific roles of individual genes are less understood. To study neuronal in vivo , we inhibited specifically C. elegans neurons, and unexpectedly found that knockdown early-acting genes, i.e., involved formation the autophagosome, except for atg-16.2 decreased PolyQ aggregates increased lifespan, albeit independently degradation autophagosomal cargo. Neuronal can be secreted from neurons via vesicles called exophers,...