A5036072052- MicroRNA in disease regulation
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Pharmacogenetics and Drug Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Drug-Induced Hepatotoxicity and Protection
- FOXO transcription factor regulation
- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- GDF15 and Related Biomarkers
Beth Israel Deaconess Medical Center
2023-2024
Institute of Genomics and Integrative Biology
2019-2022
Academy of Scientific and Innovative Research
2019-2022
National Institute of Immunology
2015-2018
// Neeraj Kumar 1,2 , Vaibhav Jain 1,* Anupama Singh Urmila Jagtap 1 Sonia Verma and Arnab Mukhopadhyay Molecular Aging Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India 2 Current address: Centre for Human Genetics Medicine, School Health Sciences Central University Punjab, Bathinda, * These authors have contributed equally to this work Correspondence to: Kumar, email: Mukhopadhyay, Keywords : DAF-16, FOXO, ChIP-seq, C. elegans, transcription, Gerotarget...
Diet profoundly affects metabolism and incidences of age-related diseases. Animals adapt their physiology to different food-types, modulating complex life-history traits like aging. The molecular mechanisms linking adaptive capacity diet with aging are less known. We identify FLR-4 kinase as a novel modulator in C. elegans, depending on bacterial diet. functions prevent differential activation the p38MAPK pathway response diverse thereby maintaining normal life span. In kinase-dead flr-4...
Zebrafish is increasingly being used to study liver injury and regeneration. However, very little known about molecular players that respond those important for We use a metronidazole nitroreductase (MTZ-nfsb)-based system selectively ablate hepatocytes in adult zebrafish create model In this study, we generate comprehensive temporal map of gene expression changes during regeneration through RNA sequencing samples at various stages Analyzing these data, find soon after the immediate early...
Abstract Liver disease is a major global health concern, claiming approximately 2 million lives worldwide annually, yet curative treatments remain elusive. In our study, we aimed to investigate the role of microRNA-21-5p (miR-21) in metabolic dysfunction-associated steatotic liver (previously NAFLD), metabolic-associated steatohepatitis NASH), and hepatocellular carcinoma (HCC) within context Western high-fat diet (HFD) offering potential therapeutic insights. We found that reduced miR-21...
Liver disease, including hepatocellular carcinoma (HCC), is a major global health concern, claiming approximately 2 million lives worldwide annually, yet curative treatments remain elusive. In this study, we aimed to investigate the role of microRNA-21-5p (miR-21) in metabolic dysfunction-associated steatotic liver disease (previously NAFLD), metabolic-associated steatohepatitis NASH), and HCC within context Western high-fat diet, without additional choline (HFD) offering potential...
The use of many essential drugs is restricted due to their deleterious effects on the liver. Molecules that can prevent or protect liver from drug-induced injury (DILI) would be invaluable in such situations. We used a transgenic line zebrafish with hepatocyte-specific expression bacterial nitroreductase cause temporally controlled damage. A whole organism-based chemical screen using identified BML-257, potent small molecule AKT inhibitor, protected against metronidazole-induced injury....
Abstract The use of many essential drugs is restricted due to their deleterious effects on the liver. Molecules that can prevent or protect liver from drug induced injury (DILI) would be valuable in such situations. We used hepatocyte-specific expression bacterial nitroreductase zebrafish cause temporally controlled damage. This transgenic line was run a whole organism based chemical screen larvae. In this we identified BML-257, potent small molecule AKT inhibitor, protected against...
Abstract Background & Aims Zebrafish is increasingly being used to study liver injury and regeneration. However, very little known about molecular players that respond participate in Here we aim generate a temporal map of gene expression changes at during regeneration the adult zebrafish liver. Methods We use metronidazole-nitroreductase (MTZ-nfsb) based system selectively ablate hepatocytes create model for Through RNA sequencing samples multiple time points comprehensive Results Gene...