A5012552552- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Analytical Methods in Pharmaceuticals
- biodegradable polymer synthesis and properties
- Hydrogels: synthesis, properties, applications
- Analytical Chemistry and Chromatography
- Nanoparticle-Based Drug Delivery
- Microbial Metabolites in Food Biotechnology
- Polysaccharides Composition and Applications
- Pharmacological Effects of Natural Compounds
- Acute Kidney Injury Research
- Renal and Vascular Pathologies
- Bee Products Chemical Analysis
- Dialysis and Renal Disease Management
- Psychosomatic Disorders and Their Treatments
- Adsorption and biosorption for pollutant removal
- Food Science and Nutritional Studies
- Dermatology and Skin Diseases
- Ethnobotanical and Medicinal Plants Studies
- Genetic Neurodegenerative Diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cancer Treatment and Pharmacology
- Treatment of Major Depression
All India Institute of Medical Sciences
2022-2024
Birla Institute of Technology, Mesra
2012-2023
Central Institute of Medicinal and Aromatic Plants
2021-2022
Birla Institute of Technology and Science, Pilani
2021
In this study, attempt has been focused to prepare a nanoemulsion (NE) gel for topical delivery of amphotericin B (AmB) enhanced as well sustained skin permeation, in vitro antifungal activity and vivo toxicity assessment.A series NE were prepared using sefsol-218 oil, Tween 80 Transcutol-P by slow spontaneous titration method. Carbopol (0.5% w/w) was containing 0.1% w/w AmB. Furthermore, (AmB-NE gel) characterized size, charge, pH, rheological behavior, drug release profile, permeability,...
Abstract In this study, four biochars prepared from different crop residue waste i.e. sugarcane bagasse (SBB), coconut shell (CNB), paddy straw (PDB), and distilled of lemongrass (LGB) were evaluated for removal Remazol Brilliant Blue R the aqueous system. The RBBR adsorption capacities biochar 97–79% SBB, 99.9–99.47% CNB, 66.1–48% PDB, 78–68% LGB, dominantly controlled by their aromaticity mineral content. Langmuir Freundlich isotherms pseudo-second-order kinetic models have described...
Objective: This investigation has focused to characterize the elastic liposome containing 5-fluorouracil (5-FU) and enhance drug permeation across stratum corneum (SC) of skin (rat) using various surfactants in vivo dermal toxicity evaluation.
To design and develop liquid solid self-nanoemulsifying drug delivery systems (SNEDDS S-SNEDDS) of felodipine (FLD) using Box-Behnken (BBD).Solubility study was carried out in various vehicles. Ternary phase diagram constructed to delineate the boundaries nanoemulsion domain. The content formulation variables, X1 (Acconon E), X2 (Cremophor EL) X3 (Lutrol E300) were optimized by assessment 15 formulations (as per BBD) for mean globule sizes Millipore water (Y1), 0.1 N HCl (Y2), phosphate...
Aim: To characterize the enhanced stability and permeation potential of amphotericin B nanoemulsion comprising sefsol-218 oil at varying pH temperature aqueous continuous phase.Methodology: Several batches loaded were prepared evaluated for their physical chemical different temperature. Also, a comparative study ex vivo drug across albino rat skin was investigated with commercial Fungisome® solution 37 °C 24 h. The extent penetrated through thereby using confocal laser scanning microscopy...
The study aimed to select a suitable solvent capable solubilize ketoconazole (KETO) and serve as permeation enhancer across the skin. Experimental solubility Hansen parameters were obtained in ethanol, dimethyl sulfoxide (DMSO), ethylene glycol, oleic acid, span 80, limonene, eugenol, transcutol (THP), labrasol, propylene glycol. Thermodynamic functional computational models (van't Hoff Apelblat) validated determined various solvents at T = 298.2 K 318.2 P 0.1 MPa. HSPiP software estimated...
Contaminations of heavy metals such as lead (Pb) and cadmium (Cd) in medicinal plants (MPs) not only restrict their safe consumption due to health hazards but also lower productivity. Biochar amendments the soil are supposed immobilize toxic metals, improve quality agricultural However, impact biochar on growth attributes, metal accumulation, pharmacologically active compounds MPs, risk is less explored. An experiment was performed three (Bacopa monnieri (L.), Andrographis paniculata...
Worldwide, there has been an increasing prevalence of kidney disorders for several years. Kidney are characterized by abnormal biomarkers like uric acid, urea, cystatin C, creatinine, injury molecule-1, C-related protein, etc., in the human body. A person suffering from is prone to other serious health consequences, such as cardiac diseases and renal failure, which can lead death. However, early diagnosis requires effective disease management prevent progression. Existing diagnostic...
This study aimed to evaluate the crystalline and amorphous carvedilol along with their lipidic mixtures using various instrumental techniques use response surface methodology in conjunction factorial design establish functional relationships between operating variables (capmul GMS 50 K cremophor RH 40). The selected are spectroscopic absorbance (Y 1), mean particle size distilled water 2) phosphate buffer pH 6.8 3), polydispersibility index (PDI) 4) zeta potential 5). optimal formulations of...
The present work focuses on preparing a solidified self nano-emulsifying drug-delivery system (S-SNEDDS) to improve the in vitro dissolution of rosuvastatin and evaluate its antihyperlipidemic activity. Powder flow characterization demonstrated good properties. drug-excipient compatibility study indicates no possible interaction. Transmission electron microscopy scanning revealed nonaggregated, spherical nanosized globules. globule-size analysis droplet size nanorange (∼100 nm). S-SNEDDS...
The primary aim of the study was to observe morphological changes taking place on Escherichia coli when treated with non-cationised placebo lipidic emulsion (NCPLE) and cationised (CPLE). particle size NCPLE CPLE indicated mean diameter 10.77 ± 0.20 nm 56.98 1.718 nm, respectively. zeta potential depicted −10.8 0.80 mV +20.9 3.25 mV, Agar diffusion higher inhibition zone 21.4 0.85 mm for as evaluated against 14.7 0.76 NCPLE. Transmission electron micrographs showed blank nanoemulsions...
The objectives of present study were to understand the effect formulation variables self-nanoemulsifying drug delivery system (SNEDDS) rosuvastatin (RSV). Box-Behnken design in conjunction with desirability function was used evaluate main effect, interaction and quadratic independent that included amounts Acconon 200 E6, Cremophor RH40, Lipoxol 300. For a better understanding selected for optimal performance RSV SNEDDS, models presented as three-dimensional response surface graphs. A fresh...
Dear Editor, Psychological pillow, a rare catatonic sign. Pathophysiology includes dysregulation of motor circuit loops, namely Cortico-subcortico-cortical loop (movement initiation/inhibition), cortico-thalamo-cerebello-subcortical (modulate movement dynamics/timing), cortico-cortical (regulate the speed and organization activity). Specifically, which dysregulates is matter ongoing debate55,56. The right inferior parietal cortex proposed to be structure involved in these functions,...