This study aimed to formulate a self-nanoemulsifying drug delivery system (SNEDDS) for enhanced pharmacokinetic (PK) behavior of rifampicin and isoniazid using excipients holding innate anti-mycobacterial activity followed with<italic>in vivo</italic>–<italic>in silico</italic>predictions GastroPlus™.

The study aimed to optimize self-nanoemulsifying drug delivery system using experimental design excipients holding innate anti-mycobacterium activities followed with characterizations for responses such as optical clarity (Y1), zone of inhibition (ZOI) against Mycobacterium smegmatis strains (Y2, Y3), and globular size (Y4). optimized formulations (OF1–OF3) were further characterized evaluated zeta potential, minimum concentration (MIC) non-pathogenic tubercular strains, morphological...

This study aimed to evaluate the crystalline and amorphous carvedilol along with their lipidic mixtures using various instrumental techniques use response surface methodology in conjunction factorial design establish functional relationships between operating variables (capmul GMS 50 K cremophor RH 40). The selected are spectroscopic absorbance (Y 1), mean particle size distilled water 2) phosphate buffer pH 6.8 3), polydispersibility index (PDI) 4) zeta potential 5). optimal formulations of...

The present study demonstrates the mechanism of bactericidal effect rendered by cationic and non-cationic lipidic emulsions using atomic force microscopy (AFM) scanning electron microscopy. AFM images treated Escherichia coli cells indicated conformational alteration from rod-shaped bacteria to a fluid-flattened structure with presence pore in centre bacterium, indicating cell lysis. Root mean square roughness increased substantially due exposure underlying rugose peptidoglycan layer when...

The primary aim of the study was to observe morphological changes taking place on Escherichia coli when treated with non-cationised placebo lipidic emulsion (NCPLE) and cationised (CPLE). particle size NCPLE CPLE indicated mean diameter 10.77 ± 0.20 nm 56.98 1.718 nm, respectively. zeta potential depicted −10.8 0.80 mV +20.9 3.25 mV, Agar diffusion higher inhibition zone 21.4 0.85 mm for as evaluated against 14.7 0.76 NCPLE. Transmission electron micrographs showed blank nanoemulsions...

The present study divulges the consequences of lipidic nanoemulsions (cationized and non-cationized) on morphology membrane integrity Staphylococcus aureus using transmission electron microscopy, scanning microscopy (SEM) atomic force (AFM). Transmission microscopic (TEM) images reveal that cationized emulsions (CLEs) remained adhered even after hostile treatment to remove by centrifugation owing electrostatic attraction between CLE negatively charged bacterial surface. TEM portray extensive...

Introduction: The study aimed to assess the effectiveness of Selaginella plana in treating diabetes. plant components were assessed using ethanol as a solvent. To determine whether extracts included any secondary metabolites, phytochemical screening was performed. Methods: quantities total phenolic and flavonoid determined ethanolic, chloroform, petroleum, water solutions. Experimental animals used evaluate antioxidant properties extracts. Thus, further processed antidiabetic activity...

Introduction: The study is aimed to assess the plant bioactive compounds of Selaginella plana in treating diabetic neuropathy. components were assessed using ethanol as solvent. Method: A phytochemical screening was conducted ascertain existence secondary metabolites extracts. efficacy extract against neuropathic pain determined plantar test and Von Frey filament stimulation. Biochemical tests performed determine level SGOT, SGPT, ALP, HDL, CHO, LDL, Creatinine Urea. percentage yield aqueous...

The present study aims to the antibacterial activity of food-grade lipidic nanoemulsion (noncationized/cationized) against Bacillus subtilis (BS). Bactericidal was ascertained by studying morphological transitions on BS using transmission electron microscopy (TEM), atomic force (AFM), and scanning (SEM). Morphological changes were witnessed cell wall breakage, oozing out cellular contents, loss turgidity contour. Furthermore, aggregation cationic (CaNM) preferentially observed at apical side...

The present study aimed to screen and optimized the levels of lipids surfactants that holds an innate antibacterial activity against gram positive negative bacteria. Gram bacteria (S. aureus B. subtilis) were found be more susceptible various explored excipients as compared Gram-negative (E. coli, P. aeruginosa). mean particle Smix in absence oleylamine decreased from 300.32 ±5.64 nm 58.43 ± 0.34 when cremophor RH 40 concentration increased 0.25% w/v 0.75% w/v. Thereafter, 1.0% 2.0% w/v,...