A5056798643- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Synthesis and Biological Evaluation
- Tuberculosis Research and Epidemiology
- Lignin and Wood Chemistry
- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Thermochemical Biomass Conversion Processes
- Phenothiazines and Benzothiazines Synthesis and Activities
- Mass Spectrometry Techniques and Applications
- Inhalation and Respiratory Drug Delivery
- Cancer therapeutics and mechanisms
- Receptor Mechanisms and Signaling
- Electrochemical Analysis and Applications
- Botanical Research and Applications
- Antibiotic Resistance in Bacteria
- Essential Oils and Antimicrobial Activity
- Antifungal resistance and susceptibility
- Quinazolinone synthesis and applications
King Saud University
2016-2025
Birla Institute of Technology, Mesra
2015-2019
Magadh University
2019
Institute of Science and Technology
2018
Maulana Azad National Institute of Technology
2018
Riyadh Elm University
2018
Birla Institute of Technology and Science, Pilani
2018
Ranchi University
2016
Hamdard University
2014
Jamia Millia Islamia
2008-2014
Cancer and the associated secondary bacterial infections is a leading cause of mortality, due to paucity effective drugs. Here, we have synthesized silver nanoparticles (AgNPs) from organic resource confirmed their anti-cancer anti-microbial potentials. Microwave irradiation method was employed synthesize AgNPs using Pandanus odorifer leaf extract. Anti-cancer potential evaluated by scratch assay on monolayer rat basophilic leukemia (RBL) cells, indicating that inhibit migration RBL cells....
Considering the significance of biological and eco-friendly nanomaterials, in present study, we have synthesized silver nanoparticles from exopolysaccharide recently recovered bacterial strain CEES51 Red Sea coastal area Jeddah, Saudi Arabia. 16S ribosomal RNA gene sequencing was used to characterize isolated bacteria, it identified as Mesoflavibacter zeaxanthinifaciens assigned an accession number MH707257.1 GenBank. The is excellent producer survived at hypersaline (30%) high-temperature...
Biofilms are complex aggregation of cells that embedded in EPS matrix. These microcolonies highly resistant to drugs and associated with various diseases. have greatly affected the food safety by causing severe losses due contamination spoilage. Therefore, novel antibiofilm agents needed. This study investigates protein binding activity zinc nanoparticles (ZnNPs) synthesized from leaf extract Ochradenus baccatus . Standard physical techniques, including UV-visible spectroscopy Fourier...
Evaluation of solid lipid nanoparticles (SLNs) for ocular delivery isoniazid (INH).INH-SLNs were characterized morphological, thermal, crystalline and nuclear magnetic resonance properties. In vitro release ex vivo corneal permeability INH-SLNs was also evaluated. Proof-of-concept uptake studies performed in conjunctival cell lines rat eye using fluorescein-labeled SLNs. Antimycobacterial activity confirmed. aqueous humor pharmacokinetics, toxicity tolerance rabbit/rat eye.INH-SLNs showed...
There is a growing interest in harnessing natural compounds and bioactive phytochemicals to accelerate drug discovery development, including the treatment of human cancers. Receptor tyrosine kinases (RTKs) are critical regulators many fundamental cellular processes have been implicated cancer pathogenesis as well targets for anticancer development. The members TAM, Tyro3, Axl, MERTK subfamily RTKs, especially Mer, affect immune homeostasis tumor microenvironment. Hence, tyrosine-protein...
Interleukin-2-inducible T-cell kinase (ITK) is a critical tyrosine enzyme that involved in the activation and differentiation of T cells. ITK mainly found cells, which plays an essential role controlling receptor signaling downstream pathways. regulates synthesis cytokines, particularly interleukin-2 (IL-2), development Th2 interest for drug discovery molecular targeting immunology, autoimmune diseases, cancer. Here, we report structure-based virtual screening utilizing collection small...
Kallikrein-related peptidase 2 (KLK2) is a serine protease exhibiting antiangiogenic properties through proteolytic activity. KLK2 overexpressed in prostate cancer and plays pivotal role progression, establishing it as potential therapeutic target. Despite the promising results of small molecule inhibitors targeting treatment, there are still many challenges development application these inhibitors. As consequence, very few have advanced to clinical trials because issues with specificity...
Abstract This study synthesized gold nanoparticles (AuNPs) using a facile microwave-assisted chemical route and evaluated them as potential anticancer candidates against breast colon cancer cell lines. Numerous spectral characterization tools were used to the optical properties, structure, morphology of prepared AuNPs. UV-Vis spectroscopy showed characteristic peak at 517 nm, which confirms formation The crystalline structure NPs was studied by X-ray diffraction, NPs’ shape size calculated...
Abstract Chiral high‐performance liquid chromatography (HPLC) separation and modeling of four stereomers DL‐leucine‐tryptophan DL‐dipeptide on AmyCoat‐RP column are described. The mobile phase applied was ammonium acetate (10 mM)‐methanol‐acetonitrile (50:5:45, v/v). flow rate the phases 0.8 mL/min with UV detection at 230 nm. values retention factors for LL‐, DD‐, DL‐, LD‐ were 2.25, 3.60, 5.00, 6.50, respectively. resolution 1.60, 1.39, 1.30 7.76, 8.05, 7.19. limits quantitation ranging...
This study aimed to formulate a self-nanoemulsifying drug delivery system (SNEDDS) for enhanced pharmacokinetic (PK) behavior of rifampicin and isoniazid using excipients holding innate anti-mycobacterial activity followed with<italic>in vivo</italic>–<italic>in silico</italic>predictions GastroPlus™.
Cyclin-dependent kinase 8 (CDK8) is highly expressed in various cancers and common complex human diseases, an important therapeutic target for drug discovery development. The CDK8 inhibitors are actively sought after, especially among natural products. We performed a virtual screening using the ZINC library comprising approximately 90,000 compounds. applied Lipinski's rule of five, absorption, distribution, metabolism, excretion, toxicity properties, pan-assay interference compounds filter...
The study aimed to optimize self-nanoemulsifying drug delivery system using experimental design excipients holding innate anti-mycobacterium activities followed with characterizations for responses such as optical clarity (Y1), zone of inhibition (ZOI) against Mycobacterium smegmatis strains (Y2, Y3), and globular size (Y4). optimized formulations (OF1–OF3) were further characterized evaluated zeta potential, minimum concentration (MIC) non-pathogenic tubercular strains, morphological...