A5044865286- Drug-Induced Hepatotoxicity and Protection
- Healthcare and Venom Research
- Animal Diversity and Health Studies
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Reproductive System and Pregnancy
- Nanoparticles: synthesis and applications
- Catalytic Cross-Coupling Reactions
- Heavy Metal Exposure and Toxicity
- Selenium in Biological Systems
- Insect Pest Control Strategies
- Curcumin's Biomedical Applications
- Insect and Pesticide Research
- Trace Elements in Health
- Protein Hydrolysis and Bioactive Peptides
- Liver Disease Diagnosis and Treatment
- Coccidia and coccidiosis research
- Nigella sativa pharmacological applications
- Natural Antidiabetic Agents Studies
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Bee Products Chemical Analysis
- Advanced Glycation End Products research
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Ferroptosis and cancer prognosis
King Saud University
2016-2025
Morocco is known for its high plant biodiversity, but many plants are poorly valorized. For this reason, study aims to valorize the methanolic and aqueous extracts of Melitotus albus leaves by studying their antioxidant activity toxicity. The extracts' assessed using FRAP, DPPH, CAT, ABTS methods. chemical composition was determined LC–MS analysis evaluated in silico studies. results revealed that total polyphenol content extract, 259.26 ± 7.79 (mg GAE/g), higher than 131.41 12.64 GAE/g)....
Diabetes mellitus alters oxidative stability and immune response. Here, we investigated the impact of a peptide extracted from camel milk (CMP) on status, transcription factor kappa-B (NF-kB) inflammatory cytokine in diabetic wounds. Rats were assigned into three groups: control, induced (DM) with multiple doses CMP for week (DM-CMP). DM showed sharp decline activity major antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) glutathione (GSH) compared to control. The DM-CMP...
Diabetes mellitus is a global epidemic leads to multiple serious health complications, including nephropathy. Diabetic nephropathy kidney-related complication of type 1 or 2 diabetes that prevalent in almost 40% the people with diabetes. We examined whether folic acid and melatonin can reduce progression rats by controlling level oxidative stress, glucose, lipids, cytokines.Forty-two male albino were distributed into six groups, (n = 7 per group). Five groups induced single intraperitoneal...
Biofilms are complex aggregation of cells that embedded in EPS matrix. These microcolonies highly resistant to drugs and associated with various diseases. have greatly affected the food safety by causing severe losses due contamination spoilage. Therefore, novel antibiofilm agents needed. This study investigates protein binding activity zinc nanoparticles (ZnNPs) synthesized from leaf extract Ochradenus baccatus . Standard physical techniques, including UV-visible spectroscopy Fourier...
Background: Immune checkpoints are receptors on the surface of T cells that function crucially in suppressing immune response, and they implicated autoimmunity cancer diseases.
Background: Coccidiosis is a serious parasitic disease caused by protozoan parasites of the genus Eimeria, presents an important risk to rabbits’ health and production. Methods: Potential bioactive compounds in extract were identified FT-IR analysis total content phenolics, tannins flavonoids was calculated. In addition, enzyme inhibitory antioxidant effects investigated. Result: The phytochemical results methanolic leaves R. nervosus showed presence 14 active chemical constituents. that had...
Background Killer immunoglobulin-like receptors (KIRs) are key molecules used by natural killer (NK) cells to interact with target cells. These exhibit extensive genotypic polymorphism which has been associated varying outcomes in immune responses against diseases. This study aimed investigate the relationships between KIR genotypes and haplotypes acute lymphoblastic leukemia (ALL) Saudi patients. Methods A total of 259 subjects including 145 cases 114 healthy controls living Riyadh were...
ABSTRACT Coccidiosis is a common disease in rabbits and caused by Eimeria spp., which poses threat to its survival. The research aims assess the effect of Vitis vinifera extract on flavescens sporozoites for inhibition viability. Twenty-four-well plates with volume 3 mL each, each containing one thousand sporulated oocysts/mL, were subjected seven different treatments: control 2.5% potassium dichromate solution; five concentrations 125, 250, 500, 750, 1000μg/mL anti-sporozoites activities....
To prepare a novel series of silver (I) complexes, the interaction benzimidazolium salts having their two nitrogen atoms substituted by bulky groups with Ag2O in DMF has been carried out. Their structures were characterized elemental analyses, 1H NMR, 13C NMR and IR spectroscopy techniques. Further, antibacterial properties both silver(I)-NHC complexes tested against positive negative bacteria using agar dilution procedure. The results show that are effective Salmonella Typhimurium, Listeria...
Traditionally, in many countries, various parts of the Adansonia digitata ( A. ) tree have been used treatment clinical ailments including diarrhea and dysentery. The phytochemical screening has indicated that leaf extract contains flavonoids, saponins, mucilage, steroids, alkaloids. Thus, this paper aims to evaluate hyperglycaemic hypolipidaemic effects methanolic leaves (200 mg/kg 400 mg/kg) diabetic rats. was administered orally for six weeks streptozotocin (STZ)-induced with caused a...
Diabetes Mellitus during wound healing alters macrophage recruitment, leading to delayed healing. The present study focuses on impact of camel milk peptide (CMP) plasticity their recruitment stages. Swiss albino rats were distributed into three groups: a normal wounded group (control), diabetic group, and treated with CMP daily. showed significantly compromised level monocyte chemoattractant protein-1 (MCP-1) inflammatory protein (MIP-1α) relative gene expression, anti-CD31, anti-Mac-3,...
Breast cancer is a serious concern for many women worldwide. Drug-loaded implants have shown several benefits over systemic administrations. To provide anti-cancer drugs with controlled release and reduced toxicity, biodegradable
Gestational diabetes (G.D.) and its effects on the offspring are some of major concerns in mothers 21st century. The present study investigates if selenium nanoparticles (SeNPs) can prevent G.D.'s ill effect pups to diabetic mother rats. For this study, rats were distributed three groups as per treatment given their mothers: DM (p) [diabetic from mothers]; D.M. + Se-NP (pups treated with Se N.P. at dose 5 mg/kg body weight twice a week for month) beside control group (C.N.). sacrificed,...
Melatonin (ML) is a potent antioxidant that reduces oxidative stress. This study was designed to examine the protective effect of melatonin on potassium dichromate- (PDC-) induced male reproductive toxicity. Forty rats were divided into five groups: control group, administered PDC orally (10 mg/kg body weight) for eight weeks, ML intraperitoneally at doses either 2.5 or 5 followed by administration PDC, and only. The treatment with led decrease in levels plasma sex hormones, glutathione,...
To assess whether SAV could influence the effects of carbon tetrachloride (CCL 4 ) exposure, mice were treated with in doses 100, 200, 300 and 400 μ g/kg body weight on oxidative status kidney function studied. Serum levels creatinine, malondialdehyde (MDA), blood urea, together renal hepatic MDA, glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) quantified order to evaluate antioxidant activity. Results showed that group injected CCL exhibited significantly higher stress...
Background: This study investigated selenium nanoparticles’ protective effects (SE-NPs) against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Methods: Rats were divided into four groups (n = 8). Group 1 rats received the vehicle solution only. 2 a single intraperitoneal injection of mL/kg CCl4 liquid paraffin (1:1 v/v). 3 was treated with SE-NPs (2.5 mg/kg) twice week for three weeks before receiving challenge. Oxidative stress, liver function, histopathology and serum lipid...
Gallic acid (GA) has significant antioxidant bioactivity and can prevent diet-induced hypertriglyceridemia by reducing adipocytes. GA was also observed to enhance cell glucose uptake. The current study looked at the effect of gallic (100 mg, 200 mg/kg orally) on liver kidney damage caused thioacetamide (TAA; 100 mg/Kg via intraperitoneal route). TAA treated thrice weekly for eight weeks, whereas administered daily. alleviated thioacetamide-induced decreases in hepatic or renal reduced...