A5073592697- Protein Interaction Studies and Fluorescence Analysis
- Surfactants and Colloidal Systems
- Alzheimer's disease research and treatments
- Proteins in Food Systems
- Analytical Chemistry and Chromatography
- Drug Transport and Resistance Mechanisms
- Protein Structure and Dynamics
- Thermodynamic properties of mixtures
- Advanced Glycation End Products research
- Nanoparticles: synthesis and applications
- Chemical and Physical Properties in Aqueous Solutions
- Spectroscopy and Quantum Chemical Studies
- Dye analysis and toxicity
- Bacterial biofilms and quorum sensing
- Biochemical Analysis and Sensing Techniques
- Protein purification and stability
- Biochemical effects in animals
- Medicinal Plants and Neuroprotection
- Lipid Membrane Structure and Behavior
- Essential Oils and Antimicrobial Activity
- Connexins and lens biology
- Oral microbiology and periodontitis research
- Probiotics and Fermented Foods
- Tuberculosis Research and Epidemiology
- Electrostatics and Colloid Interactions
King Saud University
2016-2025
Indian Institute of Science Bangalore
2024
SRM Institute of Science and Technology
2024
Uttaranchal University
2023-2024
Graphic Era University
2023-2024
Ansal University
2024
Shaqra University
2024
University of Delhi
2024
Bridge University
2024
St Clement's Hospital
2024
Mechanistic insight into the BSA–limonene interaction: biophysical and molecular docking approach.
Recent technological developments, such as the Internet of Things (IoT), artificial intelligence, edge, and cloud computing, have paved way in transforming traditional healthcare systems into smart (SHC) systems. SHC escalates management with increased efficiency, convenience, personalization, via use wearable devices connectivity, to access information rapid responses. Wearable are equipped multiple sensors identify a person's movements. The unlabeled data acquired from these directly...
Abstract Bacterial spoilage of food products is regulated by density dependent communication system called quorum sensing (QS). QS control biofilm formation in numerous pathogens and Biofilms formed on surfaces act as carriers bacterial contamination leading to health hazards. Agents inhibiting or interfering with are gaining importance a novel class next-generation preservatives/packaging material. In the present study, Zinc nanostructures were synthesised using Nigella sativa seed extract...
Sodium dodecyl sulphate (SDS), an anionic surfactant that mimics some characteristics of biological membrane has also been found to induce aggregation in proteins. The present study was carried out on 25 diverse proteins using circular dichroism, fluorescence spectroscopy, dye binding assay and electron microscopy. It appropriate molar ratio protein SDS readily induced amyloid formation all at a pH below two units their respective isoelectric points (pI) while no observed above pI. We...
Different proteins have different amino acid sequences as well conformations, and therefore propensities to aggregate. Electrostatic interactions an important role in the aggregation of revealed by our previous report (J. M. Khan et al., PLoS One, 2012, 7, e29694). In this study, we designed executed experiments gain knowledge charge variations on during events protein with lysozyme a model protein. To impart positive negative charges proteins, incubated at pH values below above pI (∼11)....
Polyphenols has attained pronounced attention due to their beneficial values of health and found prevent several chronic diseases. Here, we elucidated binding mechanism between frequently consumed polyphenol "tea catechin" milk protein bovine beta-lactoglobulin (β-Lg). We investigated the conformational changes β-Lg interaction with catechin using spectroscopic in silico studies. Fluorescence quenching data (Stern-Volmer constant) revealed that interacted via dynamic quenching. Thermodynamic...
There is grave necessity to counter the menace of drug-resistant biofilms pathogens using nanomaterials. Moreover, we need produce nanoparticles (NPs) inexpensive clean biological approaches that demonstrate broad-spectrum inhibition microbial and cytotoxicity against HepG2 cell lines. In current research work, titanium dioxide (TiO2) NPs were fabricated through an environmentally friendly green process root extract Withania somnifera as stabilizing reducing agent examine its antibiofilm...
Abstract Nanotechnology is a vast field of science with the most vibrant and conspicuous applications. The green synthesis approach cost-effective, eco-friendly, produces stable metal-based nanoparticles without use toxic chemicals. This study presents iron (FeNPs). For biosynthesis FeNPs, Phoenix dactylifera extract was used as reducing agent sulfate heptahydrate (FeSO 4 ·7H 2 O) substrate. FeNPs were characterized by different techniques including UV–Visible spectroscopy, Fourier transform...
Global emergence and persistence of the multidrug-resistant microbes have created a new problem for management diseases associated with infections. The development antimicrobial resistance is mainly due to sub-judicious unprescribed used antimicrobials both in healthcare environment. Biofilms are important their role microbial infections hence considered novel target discovery antibacterial or antibiofilm agents. In this article, zinc oxide nanoparticles (ZnO-NPs) were prepared using extract...
The investigation of the micellization a mixture cetylpyridinium bromide (CPB) and levofloxacin hemihydrate (LFH) was carried out by conductivity technique in aqueous aq. additive mixtures, including NaCl, NaOAc, NaBenz, 4-ABA, urea. aggregation behavior CPB + LFH studied considering variation contents change experimental temperature. micelle formation examined from breakpoint observed specific
The effect of solutions double-chained quaternary ammonium gemini surfactants (16-s-16, s = 4–6) was characterized on the rate constant ninhydrin (nin) and lysine (Lys) reaction using a ultraviolet–visible (UV–vis) spectrophotometer. Rate (kψ) values were obtained at different geminis. However, kψ several geminis displayed in form kψ–[gemini] profile, quantitative estimation these results elucidated employing model micellar catalysis referred to as pseudophase. role other experimental...
Conformational alterations of bovine hemoglobin (Hb) upon sequential addition glyoxal over a range 0–90% v/v were investigated. At 20% glyoxal, molten globule (MG) state Hb was observed by altered tryptophan fluorescence, high ANS binding, existence intact heme, native-like secondary structure as depicted far-UV circular dichroism (CD) and ATR-FTIR spectra well loss in tertiary confirmed near-UV CD spectra. In addition, size exclusion chromatography analysis that MG at corresponded to...
Amyloid fibril formation by proteins leads to variety of degenerative disorders called amyloidosis. While these are topic extensive research, effective treatments still unavailable. Thus in present study, two anti-tuberculosis drugs, i.e., pyrazinamide (PYZ) and D-cycloserine (DCS), also known for treatment Alzheimer's dementia, were checked the anti-aggregation anti-amyloidogenic ability on Aβ-42 peptide hen egg white lysozyme. Results demonstrated that both drugs inhibit heat induced...