A5077859334- Antibiotic Resistance in Bacteria
- Essential Oils and Antimicrobial Activity
- Nanoparticles: synthesis and applications
- Bacterial biofilms and quorum sensing
- Escherichia coli research studies
- Urinary Tract Infections Management
- Endometriosis Research and Treatment
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Ovarian function and disorders
- Probiotics and Fermented Foods
- Maternal and fetal healthcare
- Advanced Nanomaterials in Catalysis
- Uterine Myomas and Treatments
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Medicinal Plants and Neuroprotection
- Bacteriophages and microbial interactions
- Microbial Metabolism and Applications
- Ethnobotanical and Medicinal Plants Studies
- Ocular Infections and Treatments
- Ovarian cancer diagnosis and treatment
- Oral microbiology and periodontitis research
- TiO2 Photocatalysis and Solar Cells
- biodegradable polymer synthesis and properties
King Abdulaziz Hospital
2023-2024
King Saud University
2015-2023
Alfaisal University
2023
Almaarefa University
2023
King Fahd Medical City
2018-2023
King Abdullah Medical City
2023
Islamic University
2023
King Saud Medical City
2023
Hamad Medical Corporation
2022
College of Medical Sciences
2020
There is grave necessity to counter the menace of drug-resistant biofilms pathogens using nanomaterials. Moreover, we need produce nanoparticles (NPs) inexpensive clean biological approaches that demonstrate broad-spectrum inhibition microbial and cytotoxicity against HepG2 cell lines. In current research work, titanium dioxide (TiO2) NPs were fabricated through an environmentally friendly green process root extract Withania somnifera as stabilizing reducing agent examine its antibiofilm...
The prevalence of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-producing E. coli) has recently increased worldwide. This study aims at determining the antimicrobial susceptibility patterns a collection clinical urine isolates and evaluating ESBL carriage these phenotypic genotypic levels. A total 100 were collected tertiary healthcare centre in Riyadh from January 2018 to March 2018. Antimicrobial testing was carried out for all isolates. production characterized levels...
Nigella sativa (NS) is a plant that has long been utilized in traditional medicine as treatment for certain diseases. The aim of this work was to valorize the essential oil (EO) species by phytochemical analysis and antimicrobial antioxidant evaluation. EO extracted hydrodistillation from seeds (EO-NS). Phytochemical content EO-NS evaluated use gas chromatography coupled mass spectrometry (GC-MS/MS). Antioxidant ability vitro determined three assays: 2.2-diphenyl-1-picrylhydrazyl (DPPH),...
ABSTRACT Clostridium difficile is the commonest cause of hospital-acquired infection in United Kingdom. We characterized abilities 21 clinical isolates to form spores; adhere inorganic and organic surfaces, including stainless steel human adenocarcinoma cells; germinate. The composition culture media had a significant effect on spore formation, as significantly more spores were produced brain heart infusion broth (Student's t test; P = 0.018). surface relative hydrophobicity (RH) varied...
In the present study, a facile environmentally friendly approach was described to prepare monodisperse iron oxide (Fe3O4) nanoparticles (IONPs) by low temperature solution route. The synthesized were characterized using x-ray diffraction spectroscopy (XRD), Raman spectroscopy, field emission scanning electron microscopy (FESEM) measurements, Fourier-Transform Infrared Spectroscopy (FTIR), and Thermogravimetric analysis (TGA) analyses. XRD patterns revealed high crystalline quality of...
The current study aimed to screen the preliminary phytochemicals in leaf extract of medicinal plant Simarouba glauca and analyze its potential antimicrobial, antioxidant anticancer properties. phytochemical profile methanol was analyzed, bioactive compounds were identified using chromatography, FTIR GCMS. Antimicrobial activity Minimum Inhibitory Concentration (MIC) determined against 14 bacterial 6 fungal strains. Moreover, synergistic effect a with commercially available antibiotics also...
Background Rise in the number of healthcare associated or hospital acquired infections is a major problem affecting global sector. We evaluated superior antibacterial and antibiofilm photodynamic therapy (aPDT) using malachite green encapsulated mesoporous silica nanoparticles (MG-MSN) against Staphylococcus aureus Escherichia coli , which are known to be causative agents nosocomial infections. Methods Malachite (MG) was on (MSN). Fourier-transform infrared spectroscopy, Transmission...
The present study explored the phytochemicals, antibacterial, antioxidant and cytotoxic effect of Tridax procumbens leaves. leaves were dried extracted with various organic solvents. contained phytochemicals such as alkaloids, carbohydrates, polyphenols tannins respectively. Antimicrobial potentials extracts determined by performing disc diffusion techniques. Results revealed that different solvents namely methanol, ethanol ethyl acetate documented comparatively good activity against studied...
The present study evaluates the synergistic effect of sulbactam/tazobactam in combination with meropenem or colistin against multidrug resistant (MDR) Acinetobacter baumannii isolated from hospitalized patients a tertiary care hospital Saudi Arabia. During period, 54 and carbapenem-resistant isolates A. were collected blood respiratory samples ventilator-associated pneumonia bacteremia. Microbroth checkerboard assay (CBA) E-test performed to look for interface sulbactam tazobactam colistin....
Purpose: Infections associated with medical devices that are caused by biofilms remain a considerable challenge for health care systems owing to their multidrug resistance patterns. Biofilms of Pseudomonas aeruginosa and Staphylococcus aureus can result in life-threatening situations which tough eliminate traditional methods. Antimicrobial photodynamic inactivation (aPDT) constitutes an alternative method killing deadly pathogens using reactive oxygen species (ROS). This study investigated...
Green fabrication of nanoparticles has been established by means a simple, economical and environmentally pleasant process. The present investigation describes the use Myrtus communis plant leaves extract for biosynthesis silver nanoparticle. surface plasmon resonance peak at 435 nm, distinctive silver, determined synthesis AgNP. morphology particles was spherical in size with an average diameter ∼ 15 nm. Energy dispersive X-ray Fourier Transformed Infrared diffraction techniques...
Aminoglycosides (AMGs) have been extensively used to treat infectious diseases caused by Gram-negative bacteria in livestock and humans. A selective sensitive colorimetric probe for the determination of streptomycin kanamycin was proposed based on chlortetracycline-coated silver nanoparticles (AgNPs–CTC) as sensing element. Almost all tested aminoglycoside antibiotics can rapidly induce aggregation AgNPs, along with a color change from yellow orange/red. The detection antibiotics, including...
Discovering new antifungal drugs from natural products is a key target for the treatment of infections, such as candidiasis and other Candida-related infections. As current therapeutic have adverse effects on human health, discovering urgently needed. The objective this study was to evaluate activity methanolic sodium phosphate buffer extracts derived various parts Myrtus communis, plant that traditionally used in Saudi Arabia, against Candida albicans (ATCC 10213), glabrata 2001), kefyr...
Ever increasing spread of drug resistance among bacterial pathogens have rendered the current antibiotic therapy ineffective. Drug-resistant urinary tract infections caused by Gram negative such as Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, and Serratia marcescens are considered more severe life threatening because strong biofilm dependent growth characteristics majority them. Moreover, most uropathogens coordinate their complex virulence responses via a highly...
Poly-β-hydroxybutyrate (PHB) depolymerase is known to decompose PHB, biodegradable polymers and therefore has great commercial significance in the bioplastic sector. However, reports on PHB depolymerases from isolates obtained plastic-contaminated sites that reflect potential of source organism scarce. In this study, we evaluated production extracellular Microbacterium paraoxydans RZS6 isolated site municipal area Shahada, Maharashtra, India, for first time. The isolate was identified using...
The antimicrobial resistance of extraintestinal pathogenic Escherichia coli (ExPEC) has progressively been reported worldwide. This ascribed to global dissemination a single E. clone, namely sequence type 131 (E. ST131). main goal this study is determine the prevalence and molecular traits ST131 its subclones among clinical urine isolates in Riyadh, Saudi Arabia. Sixty isolates, different extended spectrum β-lactamase (ESBL) carriage, were involved study. Molecular characterization was...
Novel, safe, and effective antilisterial agents are required in order to prevent Listeria monocytogenes infections maintain food safety. This study synthesized silver nanoparticles (AgNPs) from the shoot extract of vitro-grown Tamarix nilotica (TN) characterized them using X-ray diffraction, Fourier transform infrared spectroscopy, UV-visible dynamic light scattering, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDXS), transmission (TEM). We also assessed potential...