Chronic kidney disease (CKD) is a serious health issue in the Kingdom of Saudi Arabia (KSA). In KSA, there are currently over 20,000 patients on dialysis and 9,810 undergoing follow up after transplantation.1Saudi Center for Organ Transplantation.http://www.scot.gov.saGoogle Scholar The combined prevalence renal replacement therapy estimated at 294.3 per million population.1Saudi ScholarIn Arabia, age-standardized CKD (stages 1–2, stage 3, 4, 5, not including therapy) 9,892 100,000, which...

Gestational diabetes mellitus (GDM) is a metabolic disease in pregnancy that causes carbohydrate intolerance and hyper-glycemia. Genome-wide association studies meta-analyses have found the single nucleotide polymorphisms (SNPs) rs1387153 rs10830963 of melatonin receptor 1B ( MTNR1B) gene are associated with GDM. No on MTNR1B effect GDM been performed Saudis, other Arabs, or Middle Eastern populations.Investigate genotype allele frequencies two SNPs clinical parameters related to...

Abstract Home demolition is considered a miserable and frequent reality of life for thousands Palestinian people. Recently, in January 2020, at least 44 structures were demolished by Israeli forces, displacing 87 Studies have revealed high levels stress was associated with losing family home during demolition, the doesn’t only carry out immediate effects but also long-term mental consequences. This paper aims to provide an overview literature established studies related health consequences...

BackgroundCo production of 16S rRNA methylases gene and β-Lactamase among Enterobacteriaceae isolates conferring resistance to both therapeutic options has serious implications for clinicians worldwide.MethodsTo study co existence (armA, rmtA, rmtB, rmtC, rmtD, npmA) (blaTEM-1, blaSHV-12, blaCTX-M-14) genes, we screened all phenotypic positive producing enterobacteriaceae by polymerase chain reaction (PCR) targeting above genes. A total 330 strains were collected during period out that 218...

The present study evaluates the synergistic effect of sulbactam/tazobactam in combination with meropenem or colistin against multidrug resistant (MDR) Acinetobacter baumannii isolated from hospitalized patients a tertiary care hospital Saudi Arabia. During period, 54 and carbapenem-resistant isolates A. were collected blood respiratory samples ventilator-associated pneumonia bacteremia. Microbroth checkerboard assay (CBA) E-test performed to look for interface sulbactam tazobactam colistin....

The widespread use of antimicrobials has increased the occurrence multidrug resistant microbes. commonest mechanism antimicrobial resistance in Enterobacteriaceae is production β-lactamases such as metallo-β-lactamases (MBL) and extended spectrum (ESBL). Few studies have used a molecular approach to characterize prevalence β-lactamases. Here, different was characterized by performing three multiplex PCRs targeting genes similar those described earlier publications. Antimicrobial...

Objective: In this descriptive cross-sectional study we aimed, to assess the level of depression, anxiety, insomnia and distress symptoms experienced by healthcare providers during COVID-19 pandemic in Saudi Arabia. Methods: All currently working different hospitals were invited participate study. Data gathering started March 2020 May 2020. The participants answered a five-part questionnaire which includes demographic data, 9-item Patient Health Questionnaire, 7-item Generalized Anxiety...

Relationship between Helicobacter pylori Virulence Genes and Clinical Outcomes in Saudi PatientsHelicobacter has been strongly associated with gastritis, gastric duodenal ulcers, it is a risk factor for cancer.Two major virulence factors of H. have described: the cytotoxin-associated gene product (cagA) vacuolating toxin (vacA).Since considerable geographic diversity prevalence reported, aim this work was to determine if there significant correlation different genes (cagA vacA) 68 patients,...

To investigate the prevalence, antibiotic resistant profiles, and risk factors of early fecal carriage Enterococcus faecalis (E. faecalis) staphylococci among 150 healthy Saudi neonates born in a hospital setting central Arabia.This prospective study was conducted Al-Bukayriyah General Hospital, Qassim, Arabia, between June 2012 January 2013. The E. Staphylococcus spp. isolates were identified manually, Vitek2 system used for identity confirmation at species level minimum inhibitory...

Inflammation is pivotal to the pathogenesis of diabetes mellitus (DM), but pathological alterations neutrophil−lymphocyte ratio (NLR), an emerging inflammatory index in DM management, remains understudied. The aim this study examine relationship between NLR and glycemic control Saudi population. Gender, age, WBC count, fasting blood glucose (FBG) were obtained from Al-Borg Medical Laboratories for 14,205 subjects. Means, prevalence, risk measures, diagnostic accuracy elevated hyperglycemia...

In this prospective study, consecutive isolates of Klebsiella pneumoniae were tested for different mechanisms carbapenem resistance using the modified Hodge test (MHT), Rosco Neo-Sensitabs (ROSCO). Phenylalanine arginine beta-naphthylamide assay (PABN) inhibitor-based was done on in which mechanism not identifiable by ROSCO. Among 105 selected isolates, carbapenemase production noted 100 (95%) MHT and ROSCO showed 97 (92·4%) inhibition with dipicolinic acid signifying MBL. PCR amplification...

Streptococcus pneumoniae causes life threatening infections and necessitate for impediment controlling disease; to conquer this, information is needed about serotype distribution patterns of antibiotic resistance. The present study was determine the S. isolated from entire age group individual correlate this with susceptibility. Cases pneumococcal have been reviewed serotyping Out 117 isolates 45 (39%) were penicillin-resistant, 84 (72%) erythromycin-resistant 100% co-trimoxazole resistant....

Multidrug resistance (MDR) of Acinetobacter baumannii increasingly jeopardizes the health care setting leading to substantial mortality and morbidity globally. During past decade, entirely resistant A. strains presented a real challenge clinicians posed difficulties in therapy. MDR baumannii– associated infections, with adverse clinical outcomes involving respiratory tract, blood, soft tissues, urinary central nervous system, significantly increases outlay infirmary. Being Gram-negative...

There are no generally accepted regimens for the treatment of H. pylori infection in patients with gastritis or duodenal ulcers. However, metronidazole based have been reported to be among most successful. Resistance metronidazole, clarithromycin, and amoxicillin was determined 46 clinical isolates Helicobacter Saudi Arabia tested by E test. Of these isolates, 69.5% resistant (MIC > 8 mg/l), 21% clarithromycin 1 mg/l) 11% were multiresistant. No resistance observed. more common from females...

T he neonatal gastrointestinal tract is considered sterile, but at birth the neonate exposed for first time to a wide array of bacteria from variety sources: canal via maternal vaginal and fecal microbiota, hospital environment handling by parents nursing staff. 1,2The microbiota play an essential role in health disease host through its impact on nutrition, pathogenesis immunol-Prevalence carriage extendedspectrum-and metallo-

Background: Whole-genome sequencing is one of the best ways to investigate resistance mechanisms clinical isolates as well detect and identify circulating multi-drug-resistant (MDR) clones or sub-clones in a given hospital setting. Methods: Here, we sequenced 37 Acinetobacter baumannii, 10 Klebsiella pneumoniae, 5 Pseudomonas aeruginosa collected from biobank setting King Fahad Medical City. Complete phenotypic analyses were performed, including MALDI-TOF identification antibiotic...

Pseudomonas aeruginosa is one of the most common pathogens in nosocomial infections. Many studies have documented role quorum‐sensing ( QS ) systems antibiotic tolerance P. . N ‐acyl homoserine lactones AHLs serve as signalling molecules and can be a target for modulating bacterial pathogenicity. In this study, isolates were characterized presence different types molecules. solvent extracted quantified by determination β‐galactosidase activity using Escherichia coli MG4 reporter strain....

Gram-negative bacteria communicate among themselves by cell-to-cell signaling molecules that are essential not only for interaction within the cell population, but also host–pathogen interactions during infections. Pseudomonas aeruginosa and Acinetobacter baumannii opportunistic pathogens associated with a broad range of acute chronic infections, as well causing severe nosocomial problems. The quorum-sensing system controls multiple virulence determinants such assembly factors colonizing...

The role of Helicobacter pylori in gastric carcinogenesis is unclear, but H. infection thought to predispose carriers cancer. aim this study was investigate the relationship between extent DNA damage normal epithelial cells and pylori-positive -negative gastritis according histological diagnosis. We also compared percentage cometed on surface beneath mucosal using serial incubations times.The comet assay a rapid, efficient reproducible measure single cell it used study. evaluated 52 cases...

Mycoplasma pneumoniae is increasingly recognized as a common and an important pathogen in community-acquired respiratory tract infections (RTIs) pneumonia, particularly school-age children young adults. To determine the incidence antibiotic susceptibility of M. at main hospitals Riyadh, Saudi Arabia, we studied 552 samples from patients diagnosed with different clinical diagnosis. The isolation, identification, enumeration resistance test for were performed using Pneumofast kit. There 194...

Carbapenems are broad-spectrum β-lactam antibiotics that act by inhibition of cell wall synthesis. Various families carbapenemases comprising numerous members have been identified, which may be plasmid or chromosomally encoded. More than one mechanism carbapenem resistance (carbapenem-resistant enterobacteriaceae, CRE) has identified with sporadic reports CRE infection across the world. Appearance in enterobacteriaceae is worrying as these organisms high mortality rates fewer treatment...

The purpose of this study was to evaluate the significance effect some reproductive traits (Days open, calving interval, and dry period) on productivity dairy farms by applying statistical measures. From period extended from summer 2017 winter 2020, a field survey conducted random samples dairy-producing sectors in several locations Egypt, Including Menofia, Al-Qalyubia, Beheira, Giza governorates. There were three sectors: agricultural, private, government. This included breeds: crossbred...

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