A5091352830- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Erythrocyte Function and Pathophysiology
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- Blood properties and coagulation
- Advanced Breast Cancer Therapies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Global Cancer Incidence and Screening
- Fibroblast Growth Factor Research
- HER2/EGFR in Cancer Research
- BRCA gene mutations in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Calcium signaling and nucleotide metabolism
- Ovarian cancer diagnosis and treatment
- Ferrocene Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Adipokines, Inflammation, and Metabolic Diseases
- Retinoids in leukemia and cellular processes
King Saud University
2018-2024
UPMC Hillman Cancer Center
2016-2023
Magee-Womens Research Institute
2016-2023
University of Pittsburgh
2014-2022
King Khalid University
2022
College of Medical Sciences
2021
Cancer Research Center
2016-2019
Fred Hutch Cancer Center
2018-2019
University of Denver
2019
Isfahan University of Medical Sciences
2019
Patients with breast cancer (BrCa) brain metastases (BrM) have limited therapeutic options. A better understanding of molecular alterations acquired in BrM could identify clinically actionable metastatic dependencies.
Bone metastases (BoM) are a significant cause of morbidity in patients with estrogen receptor–positive (ER-positive) breast cancer; yet, characterizations human specimens limited. In this study, exome-capture RNA sequencing (ecRNA-seq) on aged (8–12 years), formalin-fixed, paraffin-embedded (FFPE), and decalcified cancer was evaluated. Gene expression values ecRNA-seq quality metrics from FFPE or tumor showed minimal differences when compared matched flash-frozen nondecalcified tumors. then...
Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvant treatment regimens and the microenvironment. Consequences of these alterations remain poorly understood, as does their potential for clinical targeting. We utilized genome-wide molecular profiling identify therapeutic targets acquired in metastatic disease.Gene expression 21 patient-matched primary breast tumors associated was performed TrueSeq RNA-sequencing determine clinically actionable BrM target...
BackgroundInvasive lobular carcinoma (ILC) as a disease entity distinct from invasive ductal (IDC) has merited focused studies of the genomic landscape, but those to date are largely limited assessment early-stage cancers. Given that alterations develop acquired resistance endocrine therapy, on refractory ILC needed.Patients and methodsTissue 336 primary-enriched, breast-biopsied 485 estrogen receptor (ER)-positive IDC metastatic biopsy specimens 180 191 ER-positive patients was assayed with...
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that requires novel therapies in the advanced setting. To study acquired resistance to endocrine therapy ILC, we have recently performed RNA-Sequencing on long-term estrogen deprived cell lines and identified FGFR4 overexpression as a top druggable target. Here, show expression also increases dramatically endocrine-treated distant metastases, with average fold change 4.8 relative paired primary tumor for 2.4-fold...
Background and Objectives: Breast cancer is considered the most commonly diagnosed type of among women globally in Saudi Arabia. This study aimed to assess breast incidence patterns trends female population. Materials Methods: parameters were obtained from Cancer Registry (SCR). The data retrospectively analyzed for period 2001 2017 investigate changes rates. Temporal also through joinpoint regression analysis dissected by age groups administrative regions. Results: During specified period,...
Background and Objectives: Dyslipidemia is a major risk factor for cardiovascular disease (CVD). The identification of new biomarkers that may enhance the assessment lipid abnormalities promising approach in improving prediction CVD. There no information on association hemoglobin, albumin, lymphocyte, platelet (HALP) score with dyslipidemia. aim this study was to investigate clinical utility HALP light Materials Methods: A retrospective analysis 7192 subjects initiated assess between...
Fatty acid synthase is up-regulated in a variety of cancers, including prostate cancer. Up-regulation fatty not only increases production acids tumors but also contributes to the transformed phenotype by conferring growth and survival advantages. In addition, increased expression cancer correlates with poor prognosis, although mechanism(s) which this occurs are completely understood. Because expressed at low levels normal cells, it currently major target for anticancer drug design. normally...
DNA sequencing has identified a limited number of driver mutations in metastatic breast cancer beyond single base-pair the estrogen receptor (
Nickel (Ni) is an abundant environmental hazard and occupational pollutant. Exposure to Ni compounds prevalent in electroplating workers the printing industry, among others. The toxicity of manifests as dermatological, gastrointestinal, respiratory, allergic, cardiovascular symptoms. In particular, hyperbilirubinemia reticulocytosis have been detected intoxicated subjects; observation possibly implicating selective red blood cell (RBC) toxicity. Herein, interaction nickel chloride (NiCl2)...
Abstract Invasive lobular breast carcinoma (ILC) accounts for 10% to 15% of cancers diagnosed annually. Evidence suggests that some aspects endocrine treatment response might differ between invasive ductal (IDC) and ILC, patients with ILC have worse long-term survival. We analyzed The Cancer Genome Atlas dataset observed lower levels ESR1 mRNA (P = 0.002) ERα protein 0.038) in ER+ (n 137) compared IDC 554), further confirmed the difference a local UPMC cohort (ILC, n 143; IDC, 877; P...
Background: Abnormalities in fasting blood glucose (FBG) resulting hypoglycemia (OG), impaired glycemia (IFG), or hyperglycemia (HG) arise from disordered metabolic regulation caused part by inflammation. To date, there is a dearth of evidence regarding the clinical utility monocyte−lymphocyte ratio (MLR), an emerging inflammatory index, management dysglycemia. Methods: This retrospective, cross-sectional study explored MLR fluctuations as function glycemic control 14,173 Saudi subjects....
Chemotherapy-induced anemia (CIA) is a major obstacle in cancer management. Although the mechanisms governing CIA are poorly understood, recent efforts have identified suicidal erythrocyte (red blood cell, RBC) death as possible cause of CIA. [6]-Gingerol (GNG), polyphenol extracted from Zingiber officinale plant, exhibits wide array biological activities including antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, and anticancer activities, vitro vivo. However, potential...
Inflammation is pivotal to the pathogenesis of diabetes mellitus (DM), but pathological alterations neutrophil−lymphocyte ratio (NLR), an emerging inflammatory index in DM management, remains understudied. The aim this study examine relationship between NLR and glycemic control Saudi population. Gender, age, WBC count, fasting blood glucose (FBG) were obtained from Al-Borg Medical Laboratories for 14,205 subjects. Means, prevalence, risk measures, diagnostic accuracy elevated hyperglycemia...
The prevalence of cancer-associated anemia (CIA) is high, and the mechanisms governing its development remain poorly understood. Eryptosis, suicidal cell death red blood cells (RBCs), may account for CIA as it triggered by clinically approved chemotherapeutics including cisplatin paclitaxel. Physcion (PSN), an anthraquinone extracted from rhubarb other plants, has shown great promise anticancer agent. However, potential toxicity PSN to RBCs remains elusive. were isolated heparinized blood,...
Polyunsaturated fatty acids (PUFAs) may favorably influence the risk and clinical course of diabetes mellitus (DM). In particular, eicosapentaenoic acid (EPA), docosahexaenoic (DHA), arachidonic (AA) alleviate oxidative injury insulin resistance characteristic DM. Uncertainty still remains, however, as to composition proportions blood PUFAs in relation fasting glucose levels. This study, thus, aims examine patterns PUFA indices normoglycemic (NG) hyperglycemic (HG) Saudi subjects. Age,...
Colorectal cancer (CRC) is the commonest in Saudi males and third most common females. Although CRC represents a major public health challenge, resources to evaluate its burden are inadequate. This study aims elucidate magnitude of incidence trends population by age, gender, administrative region. Data for multiple measures were analyzed from Cancer Registry (SCR) retrospectively 2001 2018. Temporal further age group, region, globally using joinpoint regression analysis. The number cases...
Inauhzin (INZ) is a novel p53 agonist with antitumor activity. Anemia common side effect of chemotherapy and may arise from red blood cell (RBC) hemolysis or eryptosis. In this study, we investigate the mechanisms INZ toxicity in human RBCs. RBCs were isolated healthy donors treated concentrations (5-500 μM) for 24 h at 37 °C. Hemoglobin was photometrically measured, cells stained Annexin-V-FITC phosphatidylserine (PS), Fluo4/AM calcium, 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA)...
Risk factors of cardiovascular disease include dyslipidemia, hypertension (HTN), and anemia. Our objective is to assess the patterns dyslipidemia in anemic non-anemic hypertensive Saudi population.A retrospective, cross-sectional study gender, blood pressure, lipid markers, CBC parameters 3111 subjects, which were retrieved from database Al-Borg Medical Laboratories over a six-year period (2014-2019), was carried out. Means compared among groups prevalence, association, diagnostic accuracy...
Acrolein (Acr) is a major component in cigarette smoke and ubiquitous environmental pollutant. It also formed as product of lipid peroxidation. Following ring closure via the Michael addition, Acr modifies deoxyguanosine (dG) DNA by forming cyclic 1,N(2)-propanodeoxyguanosine adducts (OHPdG). The reactions with dG yield, depending on direction closure, two regioisomers, α- γ-OHPdG, approximately equal amounts. However, previous (32)P-postlabeling studies showed that γ isomers were detected...