A5101487100- Healthcare and Venom Research
- Aortic Disease and Treatment Approaches
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Infectious Aortic and Vascular Conditions
- DNA Repair Mechanisms
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Acupuncture Treatment Research Studies
- Aortic aneurysm repair treatments
- Telomeres, Telomerase, and Senescence
- AI in cancer detection
- RNA modifications and cancer
- Glaucoma and retinal disorders
- Photoacoustic and Ultrasonic Imaging
- Genetic factors in colorectal cancer
- Image and Signal Denoising Methods
- Cervical and Thoracic Myelopathy
- Laser Applications in Dentistry and Medicine
- Plant biochemistry and biosynthesis
- Advanced SAR Imaging Techniques
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Retinal Imaging and Analysis
- Teratomas and Epidermoid Cysts
Hefei University of Technology
2024
Beijing Anzhen Hospital
2021-2023
Capital Medical University
2021-2023
Beijing Institute of Water
2022
Nanjing University of Aeronautics and Astronautics
2020
Fudan University
2019-2020
Shanghai Institute of Computing Technology
2020
University of Pittsburgh
2017
Laboratory of Molecular Genetics
2015
National Institute on Aging
2010
8-oxo-7,8-dihydroguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) are among the most common oxidative DNA lesions substrates for 8-oxoguanine glycosylase (OGG1)–initiated base excision repair (BER). Mammalian telomeres consist of triple guanine repeats subject to damage. Here, we investigated impact damage its by OGG1 on telomere integrity in mice. The mouse cells were analyzed quantitative fluorescence situ hybridization (telomere–FISH), chromosome orientation–FISH...
Bone metastases (BoM) are a significant cause of morbidity in patients with estrogen receptor–positive (ER-positive) breast cancer; yet, characterizations human specimens limited. In this study, exome-capture RNA sequencing (ecRNA-seq) on aged (8–12 years), formalin-fixed, paraffin-embedded (FFPE), and decalcified cancer was evaluated. Gene expression values ecRNA-seq quality metrics from FFPE or tumor showed minimal differences when compared matched flash-frozen nondecalcified tumors. then...
Abstract Background and Aims Stanford type A aortic dissection (AD) is a degenerative remodelling disease marked by an exceedingly high mortality without effective pharmacologic therapies. Smooth muscle cells (SMCs) lining tunica media adopt range of states, their transformation from contractile to synthetic phenotypes fundamentally triggers AD. However, the underlying pathomechanisms governing this population shift subsequent AD, particularly at distinct temporal stages, remain elusive....
ABSTRACT Objectives To analyze and compare, using ultrasound‐based radiomics technology, fetal‐lung texture in pregnancies affected by gestational diabetes mellitus (GDM) and/or pre‐eclampsia (PE) normal pregnancies, overall at different ages. Methods In this retrospective study, 430 high‐throughput features per image were extracted from 548 ultrasound images (obtained the level of four‐chamber view heart) pregnant women who delivered between July 2018 August 2019 Obstetrics Gynecology...
Background Renal cell carcinoma (RCC) is associated with poor prognostic outcomes. The current stratifying system does not predict outcomes and therapeutic benefits precisely for RCC patients. Here, we aim to construct an immune predictive model assist clinician prognosis. Methods Herein, signature was developed, its ability confirmed in the kidney renal clear (KIRC) cohorts based on Cancer Genome Atlas (TCGA) dataset. Several immunogenomic analyses were conducted investigate correlations...
Near-infrared (NIR) light has been shown to produce a range of physiological effects in humans, however, there is still no agreement on whether and how single parameter, like the flicker frequency NIR light, affects brain. An 810[Formula: see text]nm LED was used as stimulator. Fifty subjects participated this experiment. Forty were randomly divided into four groups. Each group underwent 30-minute radiation with different frequencies (i.e., 0[Formula: text]Hz, 5[Formula: 10[Formula: text]Hz...
To determine whether intensive systolic blood pressure (SBP) lowering can benefit hypertensive patients with diabetes.We performed a pooled analysis of individual patient data from two randomized trials to compare and standard SBP targets in diabetes (STEP subgroup ACCORD-BP glycaemic group, n = 1627 2362, respectively). We defined modified primary outcome as composite stroke, major coronary artery disease (myocardial infarction unstable angina), heart failure, cardiovascular death. The...
Data on new onset postoperative atrial fibrillation (POAF) after Stanford type A dissection (STAAD) surgery was limited. This study aimed to detect the risk factors for developing POAF STAAD procedures and association between in-hospital mortality.
Objective To evaluate the association between quantitative ultrasonographic features and clinical, pathological immunohistochemical of triple negative invasive breast carcinoma(TNBC). Methods With ethical approval, 96 patients who were pathologically confirmed as TNBC retrospectively reviewed. All sub-grouped according to age, tumor size, grade, Ki67 expression level human epidermal growth factor receptor 2 (HER-2) score.Ultrasound images segmented for carcinoma mass using a...
Retrograde dissection is now recognized as an important complication following thoracic endovascular aortic repair (TEVAR). The purpose of this study to describe two different situations TAAD after TEVAR. We will introduce the surgical methods used TEVAR at our center, and evaluate its long-term prognosis.Between January 2010 October 2019, 50 patients who had previously received treatment for TBAD were admitted center a type A dissection. According patients' CT angiographies intra-operative...
Objective To study the electroacupuncture effects of single point Zusanli or Sanyinjiao on simple obese rats and to observe regulation fat metabolism.M[ethods Before after treatment,the body weights lengths in each group were measured tO calculate Lee's index;besides,total cholesteriol (TC) triglycerides (TG) rat blood also determined.Finally,the treated observed for tWO courses,and SPSS11.5 statistical software was employed conduct analysis experimental data.Results A significant difference...
ABSTRACT Bone metastases (BoM) are a significant cause of morbidity in patients with Estrogen-receptor (ER)-positive breast cancer, yet characterizations human specimens limited. In this study, exome-capture RNA-sequencing (ecRNA-seq) on aged (8-12 years), formalin-fixed paraffin-embedded (FFPE) and decalcified cancer was first evaluated. Gene expression values RNA-seq quality metrics from FFPE or tumor RNA showed minimal differences when compared to matched flash-frozen non-decalcified...
Abstract Background: Renal cell carcinoma (RCC) is associated with poor prognostic outcomes. The current stratifying system does not predict outcomes and therapeutic benefits precisely for RCC patients.Methods: Herein, an immune signature was developed, its predictive ability confirmed in the cohorts based on TCGA-KIRC dataset. Several immunogenomic analyses were conducted to investigate correlations between risk scores infiltrations, checkpoints, cancer genotypes, tumor mutational burden,...