A5100450565- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Cancer therapeutics and mechanisms
- Natural product bioactivities and synthesis
- Plant tissue culture and regeneration
- Retinoids in leukemia and cellular processes
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- 3D Printing in Biomedical Research
- melanin and skin pigmentation
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Pharmacological Effects of Natural Compounds
- Groundwater and Isotope Geochemistry
- Fungal Biology and Applications
- Toxin Mechanisms and Immunotoxins
- Extracellular vesicles in disease
- Phytochemistry and Bioactive Compounds
- Iron and Steelmaking Processes
- Phytochemical Studies and Bioactivities
- Advancements in Transdermal Drug Delivery
- DNA Repair Mechanisms
- HER2/EGFR in Cancer Research
Jilin University
2011-2025
Union Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Chinese Academy of Medical Sciences Dermatology Hospital
2018-2025
Kunming Medical University
2022-2024
Hiroshima University Hospital
2021-2024
North China University of Science and Technology
2024
China Medical University
2011-2024
Soochow University
2024
First Hospital of China Medical University
2024
Deapioplatycodin D (DPD) is a triterpenoid saponin natural compound isolated from the Chinese herb Platycodon grandiflorum that has antiviral and antitumor properties. This study aimed to investigate effects of DPD on glioblastoma (GBM) cells determine its intrinsic mechanism action. Using CCK8 assay, it was found significantly inhibited growth GBM cells. DPD-treated contained swollen degenerated mitochondria with empty vesicular bilayer membrane-like autophagic vesicle structures in...
Postmenopausal osteoporosis is a prevalent metabolic bone disorder characterized by decrease in mineral density and deterioration of microstructure. Despite the high prevalence this disease, no effective treatment for has been developed. Exercise long considered potent anabolic factor that promotes mass via upregulation myokines secreted skeletal muscle, exerting long-term osteoprotective effects few side effects. Irisin was recently identified as novel myokine significantly upregulated...
// Sensen Lin 1, * , Li Sun Xiaodan Lyu Xiongfei Ai 1 Danyu Du Nan Su Hongyang Luyong Zhang Jun Yu 2 and Shengtao Yuan Jiangsu Center for Pharmacodynamics Research Evaluation, China Pharmaceutical University, Nanjing 210009, PR Department of Molecular Biology, Cancer Hospital, These authors have contributed equally to this work Correspondence to: Yu, email: 13901591757@163.com Yuan, cpuyuanst@163.com Keywords: macrophage; lactate; CCL5-CCR5 axis; glycolysis; AMPK Received: March 21,...
Rationale: Heat shock protein 9 (HSP90) are a family of the most highly expressed cellular proteins and attractive drug targets against cancer, neurodegeneration diseases, etc. HSP90 have also been suggested to be linked lipid metabolism. However, specific function paralogs, as well underlying molecular cascades remains largely unknown. This study aims unravel paralog-specific role in metabolism try discover inhibitors. Methods: In non-alcohol fatty liver disease (NAFLD) patients, diet...
Breast cancer cells recruit surrounding stromal cells, such as cancer-associated fibroblasts (CAFs), to remodel collagen and promote tumor metastasis. Adipocytes are the most abundant partners in breast tissue, local invasion of leads proximity adipocytes, which respond generate adipocytes (CAAs). These exhibit enhanced secretion extracellular matrix related proteins, including collagens. However, role adipocyte-derived on progression still remains unclear.Adipocytes were cocultured with for...
Abstract Excessive exercise is an etiological factor of intervertebral disc degeneration (IVDD). Engineered extracellular vesicles (EVs) exhibit excellent therapeutic potential for disease-modifying treatments. Herein, we fabricate self-powered triboelectric-responsive microneedle (MN) assay with the sustainable release optogenetically engineered EVs IVDD repair. Mechanically, promotes cytosolic DNA sensing-mediated inflammatory activation in senescent nucleus pulposus (NP) cells (the master...
Our research investigates two cases involving the TINF2 gene variant (c.844C>T), demonstrating distinct phenotypes of classic dyskeratosis congenita (DC) and a novel linear hypermelanosis in narrow bands like mosaic DC. The first patient presented with DC features linked to germline mutation, while second exhibited extensive pigmentary lesions attributed somatic mosaicism. These findings underscore critical role genetic analysis, particularly affected tissues, for understanding...
Abstract Kawasaki disease (KD), described as “mucocutaneous lymph node syndrome” , affects infants and toddlers. Patients with KD suffer from an inflammatory cascade leading to vasculitis a predilection for coronary arteries. While the symptoms pathogenesis of have received more attention, precise mechanisms are still debated. Researches show that endothelial dysfunction process in leads arterial damage affect clinical outcome. In this study, we constructed Candida albicans water soluble...
Non-small-cell lung cancer (NSCLC) is the most commonly diagnosed malignant disease with leading cause of cancer-related death. Combination treatment remains major strategy in clinical therapy NSCLC. Vinorelbine (NVB), a semi-synthetic vinca alkaloid, used for advanced and metastatic NSCLC by destabilizing microtubule formation to induce mitotic arrest cell However, side effect NVB heavily affected its effectiveness therapy. Hence, it great significance develop new agents synergize decrease...
Mangiferin is a natural polyphenol compound with anti-inflammatory properties. However, there have been few reports on the effect of mangiferin periodontitis. Here, we investigated effects this experimental periodontitis and underlying mechanisms.Mice were inoculated Porphyromonas gingivalis to induce periodontitis, treated orally (50 mg/kg bodyweight, once day) for 8 wk. Then, alveolar bone loss was examined using scanning electronic microscope. Expression tumor necrosis factor-α (TNF-α)...
Diabetic retinopathy, the main microvascular complications of diabetes and one leading causes blindness worldwide. Interesting reports on role inflammatory/proangiogenic high mobility group 1 (HMGB-1) cytokine phospholipases A2 (PLA2) in neovascularization have diverted our concentration to reveal whether HMGB-1 PLA2 plays diabetic retinopathy.We performed study streptozotocin (STZ)-induced rat model. The expression levels cytokines, chemokines, cell adhesion molecules retinal tissues were...