A5100625533- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Genetics and Neurodevelopmental Disorders
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
- Analytical Methods in Pharmaceuticals
- interferon and immune responses
- Antibiotics Pharmacokinetics and Efficacy
- Immunotherapy and Immune Responses
- Hedgehog Signaling Pathway Studies
- Natural Compounds in Disease Treatment
- Congenital heart defects research
- Advancements in Transdermal Drug Delivery
- Forensic and Genetic Research
- Acne and Rosacea Treatments and Effects
- Skin Protection and Aging
- Dermatology and Skin Diseases
- T-cell and Retrovirus Studies
- Human-Animal Interaction Studies
- Inflammatory mediators and NSAID effects
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- RNA modifications and cancer
- Forensic Anthropology and Bioarchaeology Studies
- Genomics and Chromatin Dynamics
Shanghai Public Health Clinical Center
2024-2025
Kunming Institute of Zoology
2016-2025
Chinese Academy of Medical Sciences Dermatology Hospital
2008-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Chinese Academy of Sciences
2016-2025
Xi'an University of Technology
2025
Beihang University
2025
Shandong University of Technology
2022-2025
Shandong University
2025
Inner Mongolia University
2024
Abstract Dingoes are wild canids living in Australia, originating from domestic dogs. They have lived isolated both the and ancestor, making them a unique model for studying feralization. Here, we sequence genomes of 10 dingoes 2 New Guinea Singing Dogs. Phylogenetic demographic analyses show that originate dogs southern East Asia, which migrated via Island Southeast Asia to reach Australia around 8300 years ago, subsequently diverged into genetically distinct population. Selection analysis...
Wnt/β-catenin signaling plays critical roles in embryonic development and disease. Here, we identify RNF220, a RING domain E3 ubiquitin ligase, as new regulator of β-catenin. RNF220 physically interacts with β-catenin, but instead promoting its ubiquitination proteasomal degradation, it stabilizes β-catenin promotes canonical Wnt signaling. Our analysis showed that USP7, ubiquitin-specific peptidase, which is required for to stabilize The RNF220/USP7 complex deubiquitinates enhances...
Abstract Objectives The aim of this research was to explore the origin, diversification, and demographic history O1a‐M119 over past 10,000 years, as well its role during formation East Asian Southeast populations, particularly Han, Tai‐Kadai‐speaking, Austronesian‐speaking populations. Materials Methods Y‐chromosome sequences ( n = 141) lineage, including 17 newly generated in study, were used reconstruct a revised phylogenetic tree with age estimates, identify sub‐lineages. geographic...
Maldevelopment of oligodendroglia underlies neural developmental disorders such as leukodystrophy. Precise regulation the activity specific transcription factors (TFs) by various posttranslational modifications (PTMs) is required to ensure proper oligodendroglial development and myelination. However, role ubiquitination these TFs during yet unexplored. Here, we find that RNF220, a known leukodystrophy-related E3 ubiquitin ligase, for development. RNF220 depletion in oligodendrocyte lineage...
To assess the food effects and pharmacokinetic profile of oral prednisone (test preparation,5 mg) prednisolone tablets (reference using a randomized, two-period, two crossover, single-dose, fast fed trial in 48 (24 fast, 24 fed) healthy Chinese adult subjects. In trial, plasma concentrations were determined at different time points up to h parameters analyzed according concentration data by non-compartmental analysis WinNonlin software. All laboratory parameters, vital signs adverse events...
As the adoption of electric vehicles (EVs) continues to rise, pressure on charging station resources has intensified, particularly under high-load conditions, where limited infrastructure struggles meet growing demand. Issues such as uneven resource allocation, prolonged wait times, fairness concerns among different user groups, and inefficient scheduling strategies have significantly impacted overall operational efficiency experience. Against this backdrop, effective management become...
Ordered nanoporous membranes with uniform pore sizes have been widely used in various fields due to their excellent performance. The breath figure method offers a simple and controllable approach to...
Purpose To study whether fecal microbiota transplantation (FMT) can alleviate lipopolysaccharide (LPS)-induced osteoporosis (OP) by regulating the composition and abundance of gut expression level long non-coding RNA (lncRNA) TUG1 . Methods Twenty C57BL/6 mice were selected. Two randomly designated as donors, while remaining divided into control group, LPS + FMT group. Each group consisted 6 mice. The in groups intraperitoneally injected with to establish OP model, treated donor feces...
Human skin color diversity is considered an adaptation to environmental conditions such as UV radiation. Investigations into the genetic bases of have identified a group pigmentation genes contributing in African and non-African populations. Here, we present population analysis gene KITLG with previously reported signal Darwinian positive selection both European East Asian We demonstrated that there had been recurrent selective events upstream downstream regions Eurasian More importantly,...
Sonic Hedgehog (Shh) signaling plays crucial roles in patterning the ventral neural tube, which is transformed into opposing gradients of repressor and activator forms Glis. Here, we show that fine-tuning shape Gli through non-proteolytic ubiquitination-mediated nuclear exportation an important role control local cell fate. Loss RNF220, a neural-specific ubiquitin E3 ligase, leads to expansion intermediate V0 dorsal V3 neurons, while reducing V1, V2, motor neurons between them. We RNF220...
Sepiapterin reductase plays an enzymatic role in the biosynthesis of tetrahydrobiopterin, which is reported limited studies to regulate progression several tumors. However, sepiapterin hepatocellular carcinoma remains largely unknown. Here, we found that was frequently highly expressed human carcinoma, significantly associated with higher T stage, tumor node metastasis and even shorter survival patients. Furthermore, cell animal experiments showed depletion inhibited cancer proliferation...
The accurate expression of postsynaptic AMPA receptors (AMPARs) is critical for information processing in the brain, and ubiquitination a key regulator this biological process. However, roles E3 ubiquitin ligases regulation AMPARs are poorly understood. Here, we find that RNF220 directly interacts with to meditate their polyubiquitination, knockout specifically increases AMPAR protein levels, thereby enhancing basal synaptic activity while impairing plasticity. Moreover, depending on its...
Triptolide, a diterpenoid obtained from Tripteryglum wilfordii Hook.f, has attracted interest for its anti- tumor activities against human cell lines in recent years. This report focuses on anti-proliferative and pro-apoptotic melanoma A375 cells assessed by CCK8 assay, Hoechst 33258 staining flow cytometry. In addition, triptolide-induced arrest the S phase was also observed. Caspase assays showed apoptosis induced triptolide caspase-dependent probably through intrinsic apoptotic pathways....
Background All-trans retinoic acid (ATRA) has been tried for the treatment and prevention of a number epithelial cancers. However, precise mechanism by which ATRA inhibits growth cutaneous squamous cell carcinoma (cSCC) remains elusive. Aims To determine suppressive effects on human cSCC line SCL-1, explore possible mechanisms involved. Methods SCL-1 cells were treated with ATRA, then proliferation was measured 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, while...
Abstract The retrosplenial cortex (Rsp) is a transitional located between the neocortex and archicortex, but molecular mechanism specifying Rsp from archicortex remains elusive. We here report that transcription factor Satb2 required for identity during its morphogenesis. In CKO mice, boundary [i.e., subiculum (SubC)] disappears as early E17.5, efferent projection aberrant. Rsp-specific genes are lost, whereas SubC-specific ectopically expressed in of mice. Furthermore, cell-autonomous role...