A5102935591- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Drug-Induced Ocular Toxicity
- Cerebral Venous Sinus Thrombosis
- Mitochondrial Function and Pathology
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- interferon and immune responses
- Corneal surgery and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Traumatic Ocular and Foreign Body Injuries
- Facial Trauma and Fracture Management
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Ophthalmology and Visual Impairment Studies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Bacterial Infections and Vaccines
Chinese People's Liberation Army
2015-2024
Chinese PLA General Hospital
2015-2024
China Pharmaceutical University
2021-2024
Huazhong Agricultural University
2023-2024
PLA Academy of Military Science
2024
University of Warmia and Mazury in Olsztyn
2022
Charité - Universitätsmedizin Berlin
2022
Instituto Politécnico de Lisboa
2022
Universidade Nova de Lisboa
2022
Hospital Posadas
2022
Neuromyelitis optica (NMO) is a severe inflammatory autoimmune CNS disorder triggered by binding of an IgG autoantibody to the aquaporin 4 (AQP4) water channel on astrocytes. Activation cytolytic complement has been implicated as major effector tissue destruction that secondarily involves myelin. We investigated early precytolytic events in evolving pathophysiology NMO mice continuously infusing (NMO patient serum–derived or AQP4-specific mouse monoclonal), without exogenous complement, into...
Previously, the once-through CO2 chemical absorption process by biogas slurry was experimentally verified to offer unique advantages like low energy consumption, cost-effectiveness, and feasibility of fixation in plants. However, this technology also faces some challenges limitations, including a rate performance. To improve effectiveness reliability innovative CCUS technology, study proposes novel method enhance performance without affecting agricultural applications mixing with biomass ash...
Neuromyelitis Optica (NMO) is a neuroimmune disorder primarily driven by autoantibodies against aquaporin 4 (AQP4), known as NMO-IgG. Although the mechanisms underlying NMO-IgG-induced retinopathy are not fully understood, high expression of AQP4 in retinal Müller cells suggests direct interaction that may trigger inflammatory processes retina. Previous studies indicate microglia play critical role mediating immune responses, leading to neuronal dysfunction. NMO-IgG obtained from clinical...
Background/aims To evaluate the status of myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) in chronic relapsing inflammatory optic neuropathy (CRION) and investigate its different clinical characteristics prognosis. Methods Patients diagnosed with CRION were recruited by Neuro-ophthalmology Department Chinese People's Liberation Army General Hospital from December 2015 to April 2017. Based on antibody status, they assigned either MOG-CRION or seronegative-CRION groups. Results A...
To characterize macular thickness (MT) changes in Leber's hereditary optic neuropathy (LHON) patients by cirrus HD-optical coherence tomography (OCT), and to study the correlation between MT best corrected visual acuity (BCVA). Fifty-two eyes from 52 consecutive LHON 14 age- sex-matched healthy controls were scanned OCT. Affected classified into five groups according disease duration (1st group: ≤3 months; 2nd 3–6 3rd 6–9 4th 9–12 5th >12 months). was compared analyzed. The BCVA calculated....
In the present study, changes in retinal nerve fiber layer (RNFL) thickness associated with Leber's hereditary optic neuropathy (LHON) were examined by Cirrus high definition-optical coherence tomography (OCT), and correlation between RNFL best corrected visual acuity (BCVA) was evaluated. A cross-sectional study performed. Sixty-eight eyes from patients LHON 30 healthy individuals scanned. Affected divided into 5 groups according to disease duration: Group 1, ≤3 months; group 2, 4-6 3, 7-9...
Pathological optic disc cupping (ODC) is predominantly referred to as glaucoma; however, it not only glaucoma that leads pathological excavation. A number of other nonglaucomatous diseases also result in atrophy and excavation the disc. Therefore, present study, etiology (NGODC) was analyzed differentiated from glaucomatous (GODC). The morphology clinical data 19 eyes, 12 patients exhibiting NGODC, were analyzed. Of cases, none diagnosed with glaucoma, four presented neuritis, one Devic's...
ABSTRACT Demyelinating diseases consist of a variety autoimmune conditions in which the myelin sheath is damaged due to genetic and/or environmental factors. During clinical treatment, some patients undergo partial remyelination, especially during early disease stages. However, mechanisms that regulate demyelination remain unclear. The structure, formation and myelin-related gene expression are highly conserved between mammals zebrafish. Therefore, zebrafish an ideal model organism study...
<b><i>Background:</i></b> Migraine is a chronic neurological disorder. However, its pathogenesis still unclear. This study aimed to measure the posterior ocular structure in patients with migraine using enhanced depth imaging (EDI)-optical coherence tomography (OCT) and explore probable of migraine. <b><i>Methods:</i></b> A total 115 diagnosed 50 healthy volunteers were recruited. These participants underwent an examination exclude diseases....
Neuromyelitis optica spectrum disorder (NMOSD), a severe demyelinating disease, is rare among children. Plasma exchange (PE) widely used as salvage therapy for and corticosteroid-unresponsive patients with NMOSD. Presently, there are limited studies on the safety efficacy of PE in children Herein, we report case six NMOSD who received along outcomes adverse events. All (female, age at onset 4 years 9 months–13 2 months) were AQP4-IgG positive standard using COM.TEC Cell Separator. The...
Purpose: To analyze the relationship between ocular manifestations and nasal pathology.Methods: A retrospective study of 19 granulomatosis with polyangiitis (GPA) patients ophthalmic manifestations.Results: Ten cases exhibited changes in orbital structure accompanied by paranasal sinuses, 2 had chronic dacryocystisis, 1 case nasolacrimal canal stenosis. Among 17 that were finally diagnosed biopsy, 12 mucosa biopsy. Sixteen GPA CT or MRI. Nasal involvement alone was detected 14 cases. All...
Diabetic retinopathy, the main microvascular complications of diabetes and one leading causes blindness worldwide. Interesting reports on role inflammatory/proangiogenic high mobility group 1 (HMGB-1) cytokine phospholipases A2 (PLA2) in neovascularization have diverted our concentration to reveal whether HMGB-1 PLA2 plays diabetic retinopathy.We performed study streptozotocin (STZ)-induced rat model. The expression levels cytokines, chemokines, cell adhesion molecules retinal tissues were...
Light‑induced retinal injury is clinically and experimentally well‑documented. It may be categorized into three types: Photothermal, photomechanical photochemical injuries. To date, the variation in hsa‑miR‑183/96/182 cluster its potential target genes human primary pigment epithelial (RPE) cells, following visible light exposure, has not been reported. In present study, RPE cells were exposed to 4 h of constant light. The expression was determined using reverse transcription‑quantitative...
Hepatocellular carcinoma (HCC), a hypervascular solid tumor, is the most leading cause of cancer mortality worldwide. Microtubule binding agents targeting tumor vasculature have been investigated and employed clinically. C118P newly synthesized analog CA4 with improved water solubility extended half-life. The current studies pharmacological effects its active metabolite C118. Here, we first confirmed by in vitro assays that C118 exerts microtubule depolymerization activity molecular docking...