A5009198510- Nanoplatforms for cancer theranostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Photodynamic Therapy Research Studies
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Cancer, Lipids, and Metabolism
- Gene expression and cancer classification
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Photoacoustic and Ultrasonic Imaging
- Effects and risks of endocrine disrupting chemicals
- Immune Cell Function and Interaction
Zhuhai People's Hospital
2017-2024
Jinan University
2017-2024
South China University of Technology
2024
Jinan University
2019-2023
Yancheng Central Blood Station
2023
Shenzhen University
2023
Krasnodar Research Institute of Storage and Processing of Agricultural Products
2023
University of Macau
2022
Tongji University
2017
Guangdong Academy of Medical Sciences
2014-2017
Rationale: Hepatocellular carcinoma (HCC) is one of the leading causes mortality worldwide. Methyltransferase-like 3 (Mettl3), an RNA N6-methyladenosine (m6A) methyltransferase, has been shown to act as oncogene in several human cancers. However, regulatory role posttranslational modifications Mettl3 liver cancer remains elusive. Methods: SUMOylation was analyzed using immunoprecipitation and western blot assays. In vitro vivo biological functions were examined MTS, colony formation, wound...
Objective Patients with increased PD-L1 + host cells in tumours are more potent to benefit from antiprogrammed death-1/programmed death ligand-1 (PD-L1) treatment, but the underlying mechanism is still unclear. We aim elucidate nature, regulation and functional relevance of hepatocellular carcinoma (HCC). Design A total untreated 184 HCC patients was enrolled randomly. C57BL/6 mice given injection Hepa1-6 form autologous hepatoma. ELISpot, flow cytometry real-time PCR applied analyse...
Immunotherapy is an attractive treatment strategy for cancer, while its efficiency and safety need to be improved. A dual-cascade activatable nanopotentiator sonodynamic therapy (SDT) chemodynamic (CDT)-cooperated immunotherapy of deep tumors via reshaping adenosine metabolism herein reported. This (NPMCA) constructed through crosslinking deaminase (ADA) with chlorin e6 (Ce6)-conjugated manganese dioxide (MnO2) nanoparticles a reactive oxygen species (ROS)-cleavable linker. In the tumor...
Abstract Activation of cuproptosis pathway has been reported to hold great potential in the application tumor treatment. But efficacy seriously limited by insufficient accumulation sites. Therefore, herein based on strong stabilization effects metalloid element selenium (Se) copper (Cu), a photothermic Cu 2‐ x Se nanoparticle encapsulated with bioresponsive dimethyl maleic anhydride (DMMA@Cu Se) as copper‐carrier improve is constructed, thus achieving cuproptosis‐driven enhancement...
Photoacoustic (PA) technology can transform light energy into acoustic wave, which be used for either imaging or therapy that depends on the power density of pulsed laser. Here, we report photosensitizer-free polymeric nanocapsules loaded with nitric oxide (NO) donors, namely NO-NCPs, formulated from NIR light-absorbable amphiphilic polymers and a NO-releasing donor, DETA NONOate. Controlled NO release nanocapsule dissociation are achieved in acidic lysosomes cancer cells. More importantly,...
Biofilm can protect bacteria from immune attacks and antibiotic inhibition, bacterial biofilm hosted in implanted materials medical devices is a serious threat for modern system. Herein, we report biofilm-responsive caged guanidine nanoparticles (CGNs) to deeply penetrate accumulate biofilm, then efficient photothermal eradication of achieved upon NIR laser irradiation via the proof-of-concept formulation agents CGNs. In physiological conditions blood circulation, CGNs are negatively charged...
Thioredoxin reductase 1 (TXNRD1) is an antioxidant enzyme reportedly overexpressed in hepatocellular carcinoma (HCC); however, the detailed function and mechanisms of TXNRD1 HCC remain obscure. In this study, we investigated miR-125b-5p-specific regulation levels its effect on cells.We detected miR-125b-5p human tissue samples through quantitative reverse transcription polymerase chain reaction (qRT-PCR), vitro experiments were employed to investigate cell proliferation, migration, invasion....
Regulation of stimulator interferon genes (STING) pathway using agonists can boost antitumor immunity for cancer treatment, while the rapid plasma clearance, limited membrane permeability, and inefficient cytosolic transport STING greatly compromise their therapeutic efficacy. In this study, we describe an extracellular matrix (ECM)-degrading nanoagonist (dNAc) with second near-infrared (NIR-II) light controlled activation intracellular mild photothermal-augmented chemodynamic-immunotherapy...
Abstract In multiple types of tumors, fibrotic collagen is regarded as the 'highway' for cancer cell migration, which mainly modified by lysyl hydroxylase 2 (PLOD2). The previous findings have demonstrated that expression PLOD2 was regulated factors, including HIF-1 α , TGF- β and microRNA-26a/b. Although confirmed to be related poor prognosis in lung adenocarcinoma, regulatory mechanism function human adenocarcinoma poorly understood. On other hand, upregulation or hyperactivation epidermal...
Abstract The Hippo pathway plays an important role in organ development and adult tissue homeostasis, its deregulation has been implicated many cancers. signaling relies on a core kinase cascade culminating phosphorylation of the transcription coactivator Yorkie (Yki). Although Yki is key effector pathway, regulation protein stability still unclear. Here, we show that attenuates binding ubiquitin-specific protease Usp7 to Yki, which regulates through deubiquitinating Yki. Furthermore,...
Coronavirus disease 2019 (COVID-19) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in tremendous morbidity and mortality worldwide. A major underlying cause of COVID-19 is a hyperinflammatory cytokine storm severe/critically ill patients. Although many clinical trials are testing the efficacy targeting inflammatory cytokines/chemokines patients, critical mediator initiating patient death undefined. Here we suggest that immunopathological pathway...
Breast cancer cells recruit surrounding stromal cells, such as cancer-associated fibroblasts (CAFs), to remodel collagen and promote tumor metastasis. Adipocytes are the most abundant partners in breast tissue, local invasion of leads proximity adipocytes, which respond generate adipocytes (CAAs). These exhibit enhanced secretion extracellular matrix related proteins, including collagens. However, role adipocyte-derived on progression still remains unclear.Adipocytes were cocultured with for...
Abstract Zwitterionic polymers demonstrate as a class of antifouling materials with long blood circulation in living subjects. Despite extensive research on their abilities, the responsive zwitterionic that can change properties by mild outside signals are poorly explored. Herein, sulfamide‐based monomer is developed and used to synthesize series polysulfamide‐based (poly (2‐((2‐(methacryloyloxy)ethyl) dimethylammonio)acetyl) (phenylsulfonyl) amide (PMEDAPA)) nanogels drug carriers for...
Imaging-guided percutaneous microwave thermotherapy has been regarded as an important alternative nonsurgical therapeutic strategy for hepatocellular carcinoma (HCC) that provides excellent local tumor control and favorable survival benefit. However, providing a high-resolution, real-time, noninvasive imaging technique intraoperative guidance controlling postoperative residual recurrence are urgent needs the clinical setting. In this study, cisplatin (CDDP)-loaded nanocapsule (NPs@CDDP) with...