A5101789877- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Machine Learning in Bioinformatics
- Plant Stress Responses and Tolerance
- RNA and protein synthesis mechanisms
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Extracellular vesicles in disease
- Genomics and Phylogenetic Studies
- Cloud Data Security Solutions
- Cryptography and Data Security
- Liver Disease Diagnosis and Treatment
- Dendrimers and Hyperbranched Polymers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant Molecular Biology Research
- Advanced Steganography and Watermarking Techniques
- Hedgehog Signaling Pathway Studies
- Liver Disease and Transplantation
- Bioinformatics and Genomic Networks
- Internet Traffic Analysis and Secure E-voting
- Nanoparticle-Based Drug Delivery
- Protein Structure and Dynamics
Institute of Botany
2023-2025
University of Chinese Academy of Sciences
2023-2025
Beijing Botanical Garden
2025
Northeast Agricultural University
2021-2025
Qingdao Agricultural University
2025
Hong Kong University of Science and Technology
2025
Jiangxi Normal University
2024
Beijing University of Technology
2024
Shandong University of Technology
2024
First Hospital of China Medical University
2021-2023
Abstract The Hippo pathway plays an important role in organ development and adult tissue homeostasis, its deregulation has been implicated many cancers. signaling relies on a core kinase cascade culminating phosphorylation of the transcription coactivator Yorkie (Yki). Although Yki is key effector pathway, regulation protein stability still unclear. Here, we show that attenuates binding ubiquitin-specific protease Usp7 to Yki, which regulates through deubiquitinating Yki. Furthermore,...
Di-(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in plastic products, consumer and packaging materials. It of great health concern both animals humans it released into the environment entered body from products over time, thereby resulting neurotoxicity. As pivotal regulator central nervous system (CNS), astrocytes, are crucial for maintaining brain homeostasis. Nevertheless, underlying reason astrocyte neurotoxicity due to DEHP exposure remains incompletely understood....
Cadmium is a global ecological toxic pollutant; in animals, hepatotoxic fibrosis caused by bioaccumulation of Cd through food chains. We determined the path nano-Se antagonism Cd-induced hepatocyte pyroptosis targeting APJ-AMPK-PGC1α pathway, using an vivo model hepatotoxicity. All 1-day-old chicks were treated with (140 mg/kg BW/day) and/or (0.3 or 0.6 for 90 days. The result showed that (1.55 ± 0.148) activated NLRP3 inflammasome 49.903% as compared to Con group (1.034 0.008) release...
Abstract Emerging evidence suggests that long noncoding RNAs (lncRNAs) are involved in regulation of plant response to environmental stress. CBF/DREB1 s highly conserved transcription factors regulate cold stress plants. However, very few lncRNAs were found expression CBFs and tolerance plant. Here, we identified a cold‐responsive intergenic RNA ( MtCIR2 ) CBF / DREB1 genes located major freezing QTL region legume Medicago truncatula . We was more rapid than MtCBF/DREB1 during treatment....
Abstract Elucidating the expression of microRNAs in developing single cells is critical for functional discovery. Here, we construct scCAMERA (single-cell cartography microRNA based on reporter assay), utilizing promoter-driven fluorescent reporters conjunction with imaging and lineage tracing. The delineates transcriptional activity 54 conserved lineage-resolved throughout C. elegans embryogenesis. combinatorial partitions into fine clusters reflecting their function anatomy. Notably,...
Di(2-ethylhexyl) phthalate (DEHP), which is widely used in agricultural plastics, accumulates humans and animals through the food chain over time, resulting liver toxicity. Recent studies have reported that pyroptosis mitochondrial damage are closely related to a variety of diseases, but specific mechanism still unclear. To address this issue, vitro vivo hepatotoxicity models were established. The results demonstrated exposure DEHP caused buildup MEHP livers, altered metabolite composition,...
QN Orange scallops are interspecific hybrids with orange adductor muscles that rich in carotenoids. In this study, analysis of miRNA expression profiles was performed to explore possible regulatory patterns involved carotenoid accumulation scallops. A total 91 differentially expressed between the white and were identified. GO KEGG target genes miRNAs revealed enrichments transmembrane transporter activity-related pathways, kinase signal transduction-related ATP binding cassette transporters...
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder influenced by both genetic and environmental factors. Identifying therapeutic targets interventions remains challenging. This study utilized Mendelian Randomization (MR) to investigate causal relationships between plasma proteins, lifestyle factors, AD, along with virtual screening identify potential drug compounds. A two-sample MR analysis assessed associations identified through genome-wide association studies (GWAS), AD...
Although colorectal cancer (CRC) is a prevalent malignancy of the digestive system, underlying mechanisms CRC tumorigenesis are still elusive. Arrestin-related domain-containing protein-3 (ARRDC3) has been reported to promote lysosome-mediated protein degradation. In present study, we find that expression ARRDC3 downregulated in specimens. Mechanistically, reveal binds and decreases oncoprotein YAP, cotranscription factor Hippo pathway. The regulation pathway by conserved from Drosophila...
Microwave hyperthermia is an emerging minimally invasive therapy in which thermal damage and apoptosis of tumor cells are induced by local heating tissues with microwave radiation. Recently, has been widely used clinical practice; however, uneven aggregation dispersion malignant tumors after the main problems associated this method. In work, a microridged waveguide antenna operating frequency 915 MHz was designed. Although its volume only 6.6 cm
The food calorie estimation system (FCES) is designed to record dietary information for diabetic patients monitor their intake estimate the number of calories they are consuming.Deep learning technologies have recently been used FCESs.In this work, we use neural network pattern recognition images calculate calories.In contrast traditional convolutional network, build a semantic segmentation model based on SegNet + MobileNet segment and extract area feature images.By determining corresponding...
Domestic animals show considerable genetic diversity. Previous studies suggested that animal phenotypes were affected by miRNA-mRNA interplay, but these focused mainly on the analysis of one or several interactions. However, in this study, we investigated and miRNA-lncRNA interactions a genomic scale using miranda targetscan algorithms. There has been strong directional artificial selection practiced during domestication animals. Thus, SNPs located miRNAs miRNA binding sites found 3'-UTRs...
Abstract Hedgehog (Hh) pathway plays multiple roles in many physiological processes and its dysregulation leads to congenital disorders cancers. Hh regulates the cellular localization of Smoothened (Smo) stability Cubitus interruptus (Ci) fine-tune signal outputs. However, underlying mechanisms are still unclear. Here, we show that scaffold protein Rack1 dual signaling. In absence Hh, promotes Ci Cos2 form a Ci–Rack1–Cos2 complex, culminating Slimb-mediated proteolysis. presence dissociates...
We have proposed new amino acid secondary structure propensities in proteins with different folding types based on synonymous codons. They been derived from 200 all alpha, beta, alpha/beta, and alpha + beta of known structures their coding genes. The the same codon gene for type are not same. For instance, Ile coded by AUU is indifferent to form unit protein class, but it a former breaker class alpha/beta respectively. On other hand, codons genes also As an example, CGU, CGG, AGA, which Arg,...
Abstract Metastasis is an important cause of death from malignant tumors. It great significance to explore the molecular mechanism metastasis for development anti-cancer drugs. Here, we find that Hippo pathway hampers tumor cell in vivo. Silence hpo or its downstream wts promotes migration a Yki-dependent manner. Furthermore, identify inhibition through transcriptional activating src42A , Drosophila homolog SRC oncogene. Yki activates transcription direct binding intron region. Intriguingly,...
Reversing the immunosuppressive tumor microenvironment (TME) in is widely deemed to be an effective strategy improve immune therapy. In particular, redox balance TME needs well controlled due its critical role mediating functions of various cells, including cancer cells and immune-suppressive cells.Here, we propose efficient reshape homeostasis reverse TME. Specifically, developed a microwave-chemo-immunostimulant CMMCP promote infiltration tumor-T by simultaneously reducing reactive oxygen...