A5024804765- Effects and risks of endocrine disrupting chemicals
- Paraquat toxicity studies and treatments
- Hematological disorders and diagnostics
- Liver Disease Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- Bone and Joint Diseases
- Microtubule and mitosis dynamics
- Mycotoxins in Agriculture and Food
- Drug Transport and Resistance Mechanisms
- Nephrotoxicity and Medicinal Plants
- Biomedical Research and Pathophysiology
- Reproductive Biology and Fertility
- Connexins and lens biology
- Inflammasome and immune disorders
- Effects of Radiation Exposure
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Cancer Genomics and Diagnostics
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Trace Elements in Health
- Advanced Glycation End Products research
Northeast Agricultural University
2022-2025
Jiangsu University
2020
Xuzhou Cancer Hospital
2020
Huazhong Agricultural University
2013-2016
The University of Texas MD Anderson Cancer Center
1996-2001
Di-(2-ethylhexyl) phthalate (DEHP), as the most common phthalate, has been extensively used a plasticizer to improve plasticity of agricultural products, which pose severe harm human health. Mitochondrial dynamics and endoplasmic reticulum (ER) homeostasis are indispensable for maintaining mitochondria-associated ER membrane (MAM) integrity. In this study, we aimed explore effect DEHP on nervous system its association with ER-mitochondria interaction. Here, showed that caused morphological...
Di-2-ethylhexyl phthalate (DEHP) is frequently used as a plasticizer to enhance the plasticity and durability of agricultural products, which pose adverse effects human health environment. Aquaporin 1 (AQP1) main water transport channel protein involved in maintenance intestinal integrity. However, impact DEHP exposure on gut its potential mechanisms remain elusive. Here, we determined that induced compromised duodenum structure, was concomitant with mitochondrial structural injury...
Phthalates exposure is a major public health concern due to the accumulation in environment and associated with levels of testosterone reduction, leading adverse pregnancy outcomes. However, relationship between phthalate-induced level decline ferroptosis remains poorly defined.
Butachlor is widely used in agriculture around the world and therefore poses environmental public health hazards due to persistent poor biodegradability. Ferroptosis a type of iron-mediated cell death controlled by glutathione (GSH) GPX4 inhibition. P62 an essential autophagy adaptor that regulates Keap1 activate nuclear factor erythroid 2-related 2 (Nrf2), which effectively suppresses lipid peroxidation, thereby relieving ferroptosis. Here, we found butachlor caused changes splenic...
Mycotoxin contamination is a universal agricultural problem and critical health issue. Fumonisin B1 (FB1) one of the most toxic extensive fumonisins that exist in various agro-products foods. Lycopene (LYC), as natural carotenoid, becoming increasingly favored owing to its oxidation resistance. Here, we aim explore mechanism FB1-induced hepatotoxicity antagonism LYC. In this study, our findings indicated FB1 induced mitochondrial structure damage loss function chicken hepatocytes....
Di(2-ethylhexyl) phthalate (DEHP), which is widely used in agricultural plastics, accumulates humans and animals through the food chain over time, resulting liver toxicity. Recent studies have reported that pyroptosis mitochondrial damage are closely related to a variety of diseases, but specific mechanism still unclear. To address this issue, vitro vivo hepatotoxicity models were established. The results demonstrated exposure DEHP caused buildup MEHP livers, altered metabolite composition,...
Male infertility is a multifactorial pathological condition and may be harbinger of future health. Phthalates are ubiquitous environmental contaminants that have been implicated in the global decline male fertility. Among them, di-(2-ethylhexyl) phthalate (DEHP) most prevalently used. Lycopene (LYC) possible preventive therapeutic agent for owing to its antioxidant properties. The blood-testis barrier (BTB) formed between Sertoli cells where it creates unique microenvironment...
Di-(2-ethylhexyl) phthalate (DEHP) is frequently used as a plasticizer in industrial and agricultural products. DEHP can cause severe neurotoxicity, such impaired learning memory function. Lycopene (LYC) carotenoid exerts excellent antioxidant capacity therapeutic effects neurodegenerative diseases. However, whether LYC prevent the cognitive impairment induced by specific mechanisms are unclear. In present study, behavioral test results suggested that alleviated DEHP. The histopathological...
ABSTRACT Atrazine (ATR) is a widespread environmental herbicide that seriously affects agricultural work and human safety. Melatonin (MLT) as an endogenous neuroendocrine hormone widely found in animals plants, which have antioxidant anti‐inflammatory effects. Pink1/Parkin‐mediated mitophagy keeps normal physiological processes by degrading damaged mitochondria cells. Therefore, we investigated the potential role mechanism of MLT ATR‐induced toxic injury spleen. The results showed alleviated...
Bora is the binding partner of Aurora A, which required for its activation and phosphorylation Polo like kinase 1 (Plk1), involved in spindle assembly progress cell cycle during mitosis. In this study, we examined expression, localization, function mouse oocyte meiosis. The expression level was increased meiotic maturation, with an elevated at metaphase. Immunofluorescence analysis showed that concentrated as a dot shortly after germinal vesicle breakdown (GVBD), associating first...
Objective: To investigate the CT features of lung injury induced by paraquat poisoning and its relationship with prognosis, to provide reference for judgment condition prognosis poisoning. Methods: 146 cases patients were treated in Third People's Hospital Xuzhou City from January 2013 April 2016. The divided into mild group, moderate-severe group fulminant according concentration urine. clinical data imaging findings analyzed reconstructed three-dimensional reconstruction. extent lesion was...