A5047917374- Cardiac electrophysiology and arrhythmias
- MicroRNA in disease regulation
- Immune cells in cancer
- Nitric Oxide and Endothelin Effects
- Analytical Methods in Pharmaceuticals
- Cancer Immunotherapy and Biomarkers
- Ion channel regulation and function
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Advanced biosensing and bioanalysis techniques
- Antibiotics Pharmacokinetics and Efficacy
- Neuroscience and Neural Engineering
- RNA Interference and Gene Delivery
- Pharmacological Effects and Toxicity Studies
- Ion Channels and Receptors
- Circular RNAs in diseases
- Metabolomics and Mass Spectrometry Studies
- Immune Cell Function and Interaction
- Electronic and Structural Properties of Oxides
- Renin-Angiotensin System Studies
- Heart Rate Variability and Autonomic Control
- Smart Materials for Construction
- Drug Transport and Resistance Mechanisms
- Nanoplatforms for cancer theranostics
- Ovarian cancer diagnosis and treatment
Zhuhai People's Hospital
2019-2025
Jinan University
2019-2025
Wenzhou Medical University
2024
Jinhua Academy of Agricultural Sciences
2022-2024
Advanced Research Institute
2023
Huangshi Central Hospital
2023
Xiangya Hospital Central South University
2018
Central South University
2004-2018
Guangdong Academy of Medical Sciences
2008-2017
Guangdong General Hospital
2008-2017
Tumor immunotherapy, an innovative anti-cancer therapy, has showcased encouraging outcomes across diverse tumor types. Among these, the PD-1/PD-L1 signaling pathway is a well-known immunological checkpoint, which significant in regulation of immune evasion by tumors. Nevertheless, considerable number patients develop resistance to anti-PD-1/PD-L1 rendering it ineffective long run. This research focuses on exploring factors PD-1/PD-L1-mediated immunotherapy. Initially, characterized its role...
Objective Patients with increased PD-L1 + host cells in tumours are more potent to benefit from antiprogrammed death-1/programmed death ligand-1 (PD-L1) treatment, but the underlying mechanism is still unclear. We aim elucidate nature, regulation and functional relevance of hepatocellular carcinoma (HCC). Design A total untreated 184 HCC patients was enrolled randomly. C57BL/6 mice given injection Hepa1-6 form autologous hepatoma. ELISpot, flow cytometry real-time PCR applied analyse...
Rapid development of resistance to sorafenib and subsequent hyperprogression in patients with advanced hepatocellular carcinoma (HCC) pose significant challenges, the underlying mechanisms still largely unknown. Herein, sorafenib-induced TRIB3 is identified as a liver-specific determinant driving secondary by facilitating accumulation protumorigenic neutrophils within tumors. Mechanistically, TRIB3, triggered sorafenib-elicited ROS-ER stress axis, operates an NF-κB-dependent manner...
New Delhi metallo-β-lactamases (NDMs), including at least 28 variants, are a rapidly emerging family of β-lactamases worldwide, with variety infections caused by NDM-positive strains usually associated very poor prognosis and high mortality. NDMs the most prevalent carbapenemases in Escherichia coli (E. coli) especially China. The vast majority blaNDM cases occur on plasmids, which play vital role dissemination blaNDM. To systematically explore relationships between plasmids genes E. obtain...
Metastatic tumors are mainly composed of neoplastic cells escaping from the primary tumor and inflammatory egressing bone marrow. Cancer cell remained in state immaturity during migration to distant organs. Here, we show that ADRB3 is crucial mobilization differentiation. Immunohistochemistry revealed expression significantly more frequent breast cancer tissues than adjacent noncancerous (92.1% vs. 31.5%). Expression correlated with malignant degree, TNM stage poor prognosis. Moreover, was...
Hepatocellular carcinoma (HCC), a hypervascular solid tumor, is the most leading cause of cancer mortality worldwide. Microtubule binding agents targeting tumor vasculature have been investigated and employed clinically. C118P newly synthesized analog CA4 with improved water solubility extended half-life. The current studies pharmacological effects its active metabolite C118. Here, we first confirmed by in vitro assays that C118 exerts microtubule depolymerization activity molecular docking...
Abstract A high‐performance liquid chromatography method with fluorescence detection (HPLC‐FLD) for the determination of levofloxacin in human plasma is described. Neutralized phosphate buffer (pH 7.0), sample (0.1 mL) was extracted dichlormethane (1 mL). After voltex‐mixing and centrifuged at 3000 g 6 min 4°C, upper aqueous layer aspirated using a micro vacuum pump organic directly transferred to clean test tube without pipetting. The solvent evaporated residues were reconstituted mobile...
Photodynamic therapy (PDT) has provided a promising approach for the treatment of solid tumors, while therapeutic efficacy is often limited due to hypoxic tumor microenvironment, resulting in metastasis. Herein, we report an oxygen-producing proenzyme hydrogel (OPeH) with photoactivatable enzymatic activity PDT enabled metastasis-inhibiting combinational breast cancer. This OPeH based on alginate composed protoporphyrin IX (PpIX) conjugated manganese oxide (MnO2) nanoparticles, which act as...
Contrast medium (CM) is widely used in cardiac catheterization; however, it may induce acute kidney injury or renal failure, although the underlying mechanism remains to be elucidated. MicroRNA‑21 (miR‑21) involved disease and has been indicated regulate cellular apoptosis fibrosis, its role CM‑induced cell unknown. The present study examined expression potential targets of miR‑21 human proximal tubular epithelial (HK‑2) cells following CM treatment. induced decreased expression. level...
The combination of cerebellar degeneration, hypogonadotropic hypogonadism and chorioretinal dystrophy defines Boucher‑Neuhäuser syndrome (BNS), which has been associated with autosomal‑recessive mutations in the patatin‑like phospholipase domain containing 6 (PNPLA6) gene. However, no BNS cases have reported mainland China. In present study, to best authors' knowledge, first patient was identified A 39‑year‑old male diagnosed hypogonadism. proband additionally exhibited retinal degeneration...
Background: The renin–angiotensin system (RAS) is regarded as one of the most important regulatory systems for cardiovascular homeostasis. In this study, we investigated associations five genetic polymorphisms in RAS and presence coronary artery disease (CAD) type 2 diabetes. Methods: Genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism analysis. We used generalised multifactor dimensionality reduction (GMDR) method to identify gene–gene...
Tribble pseudokinase 3 (TRIB3) plays a key role in regulating the malignancy of many tumors. This study examined its function cancer cells and explored potential mechanisms action.The expression TRIB3 was hepatocellular carcinomas (HCCs) using The Cancer Genome Atlas (TCGA) database. A lentivirus with flag label constructed transfected into Huh7 Hep3B human hepatoma cell lines to generate that stably overexpress TRIB3. small interfering RNA (siRNA) designed knockdown mRNA HepG2 Huh7. Cell...