A5100358471- Immune cells in cancer
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Immunotherapy and Immune Responses
- Thyroid Disorders and Treatments
- Alkaloids: synthesis and pharmacology
- Immune Response and Inflammation
- Neuroscience of respiration and sleep
- Calcium Carbonate Crystallization and Inhibition
- Phytoestrogen effects and research
- Sphingolipid Metabolism and Signaling
- Cancer, Lipids, and Metabolism
- Phytochemistry and Biological Activities
- Ginger and Zingiberaceae research
- Stability and Control of Uncertain Systems
- Soil Geostatistics and Mapping
- Saffron Plant Research Studies
- Sesame and Sesamin Research
- Cancer Cells and Metastasis
- Stability and Controllability of Differential Equations
- 3D Printing in Biomedical Research
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
Nanjing University of Chinese Medicine
2015-2025
Jiangsu Provincial Academy of Traditional Chinese Medicine
2015-2023
Zhongda Hospital Southeast University
2023
Nanjing Medical University
2023
Guangdong Academy of Medical Sciences
2022
Guangdong Provincial People's Hospital
2022
Chongqing University
2020
Beijing Institute of Petrochemical Technology
2018
Jiangsu Province Hospital
2016
Objective: Curcumin being used to treat various chronic diseases while its poor bioavailability issue limited wide clinical application as a therapeutic agent. The aim of this work was prepare curcumin-loaded self-assembled micelles using soluplus and solutol®HS15 (SSCMs) enhance curcumin's solubility thus oral bioavailability.Methods: Optimum formulation investigated the optimized ratio drugs excipients obtained SSCMs were prepared via ethanol solvent evaporation method. optimal...
Genistein (GEN), is a natural dietary isoflavone, has been reported to show anticancer activities. However, its poor aqueous solubility and oral bioavailability limit clinical application. We designed novel genistein-loaded mixed micelles (GEN-M) system composed of Soluplus® Vitamin E d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) were prepared by organic solvent evaporation aimed overcome the challenges GEN’s then further improve bioavailability. The optimized, spherical-shaped...
Abstract Background Macrophages are indispensable regulators of inflammatory responses. Macrophage polarisation and their secreted factors have an association with the outcome inflammation. Luteolin, a flavonoid abundant in plants, has anti-inflammatory activity, but whether luteolin can manipulate M1/M2 bone marrow-derived macrophages (BMDMs) to suppress inflammation is still unclear. This study aimed observe effects on polarity BMDMs derived from C57BL/6 mice expression factors, explore...
Metastatic tumors are mainly composed of neoplastic cells escaping from the primary tumor and inflammatory egressing bone marrow. Cancer cell remained in state immaturity during migration to distant organs. Here, we show that ADRB3 is crucial mobilization differentiation. Immunohistochemistry revealed expression significantly more frequent breast cancer tissues than adjacent noncancerous (92.1% vs. 31.5%). Expression correlated with malignant degree, TNM stage poor prognosis. Moreover, was...
The effects of organic and inorganic additives on crystal morphology have been extensively studied in various materials. However, the basic fundamentals behind control are still under debate due to differences experimental observations lack technical means microenvironments where grows. Microfluidic technology with convenient operation precise related parameters provides a unique tool for investigation crystallization processes micrometer even nanometer scale. A concentration-gradient...
Thyroid hormones are metabolic indicators to evaluate the physical condition of emergency hospitalized patients, while relationship between total triiodothyronine and severity inpatients is still unclear. To explore thyroid function levels in ward status combined Nonthyroidal illness syndrome (NTIS), emphasize importance hormone examination for non-endocrinology inpatients. According ward, they were divided into NTIS group non-NTIS group, hematological characteristics TH each analyzed. Based...
Based on the extreme value conditions of a multiple variables function, new class Wirtinger-type double integral inequality is established in this paper. The proposed generalizes and refines classical Wirtinger-based has less conservatism comparison with Jensen's other inequalities literature. Thus, stability criteria for delayed control systems derived by refined are conservative than existing results
Abstract Ferroptosis is an iron-dependent cell death induced by the oxidation of polyunsaturated fatty acids. In recent years, ferroptosis has garnered tremendous potential in cancer therapy. However, significance pathways chronic myeloid leukemia (CML) therapy are still poorly understood. Here, we investigated role a critical antioxidant protein, thioredoxin 1 (Trx1), regulating CML cells. First, showed that Trx1 expression was higher patients with than healthy controls. Specifically,...
<title>Abstract</title> The authors have requested that this preprint be removed from Research Square.
ABSTRACT Macrophage are indispensable regulator cells in inflammatory response. polarization and its secreted factors have affinity with the outcomes of inflammation. Luteolin, a flavonoid abundant plants has anti-inflammatory activity, but whether luteolin can manipulate M1/M2 BMDM to suppress inflammation is still veiled. The purpose this study was observe effects luterolin on polarity derived from C57BL/6 mice expression factors, explore mechanism regulating polarity. M1-polarized were...