A5034069597- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Medicinal Plant Pharmacodynamics Research
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Flavonoids in Medical Research
- Gut microbiota and health
- Food Quality and Safety Studies
- Magnolia and Illicium research
- Phytoestrogen effects and research
- Inflammatory Bowel Disease
- Nanoparticle-Based Drug Delivery
- Chromatography in Natural Products
- Gastrointestinal motility and disorders
- Medicinal Plants and Bioactive Compounds
- Medicinal plant effects and applications
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Studies
- Ginkgo biloba and Cashew Applications
- Plant-based Medicinal Research
- Phytochemical compounds biological activities
- Natural Compounds in Disease Treatment
- Fatty Acid Research and Health
- Neurological Disease Mechanisms and Treatments
- Drug Solubulity and Delivery Systems
Jiangsu Provincial Academy of Traditional Chinese Medicine
2012-2025
Nanjing University of Chinese Medicine
2016-2025
Anhui University of Traditional Chinese Medicine
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Institute of Botany
2013
Chinese Academy of Sciences
2013
China Pharmaceutical University
2009-2012
Nanjing University
2007
China Railway Construction Corporation (China)
2007
Objective: Curcumin being used to treat various chronic diseases while its poor bioavailability issue limited wide clinical application as a therapeutic agent. The aim of this work was prepare curcumin-loaded self-assembled micelles using soluplus and solutol®HS15 (SSCMs) enhance curcumin's solubility thus oral bioavailability.Methods: Optimum formulation investigated the optimized ratio drugs excipients obtained SSCMs were prepared via ethanol solvent evaporation method. optimal...
Genistein (GEN), is a natural dietary isoflavone, has been reported to show anticancer activities. However, its poor aqueous solubility and oral bioavailability limit clinical application. We designed novel genistein-loaded mixed micelles (GEN-M) system composed of Soluplus® Vitamin E d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) were prepared by organic solvent evaporation aimed overcome the challenges GEN’s then further improve bioavailability. The optimized, spherical-shaped...
Abstract Objectives With the purpose of developing a curcumin phospholipid complex (CPC) formulation with high performance, CPC was prepared and solidified Soluplus® in this study. Methods used as carrier to solidify CPC. The structures – powder (CSP) were also characterized by differential scanning electron microscope, calorimetry, Fourier transform infrared spectroscopy X-ray diffractometer, flowability, in-vitro dissolution oral bioavailability investigated. Key findings All analysis...
Background: Targeted prodrug has various applications as drug formulation for tumor therapy. Therefore, amphoteric small-molecule combined with nanoscale characteristics the self-assembly of nano-drug delivery system (DDS) is a highly interesting research topic. Methods and Results: In this study, we developed self-assembled nanoplatform, 2-glucosamine-fluorescein-5(6)-isothiocyanate-glutamic acid-paclitaxel (2DA-FITC-PTX NPs) by integration targeted small molecule nano-DDS regular structure...
Chlorogenic acid (CA) and sodium alginate (SA) each have good therapeutic effects on ulcerative colitis (UC) owing to their antioxidant anti-inflammatory activity. This study aimed investigate the of CA alone in combination with SA inflammatory cells UC mice. In Lipopolysaccharide (LPS)-induced RAW 264.7 cell model, Nitric oxide (NO) interleukin-6 (IL-6) levels were significantly lower after treatment plus than alone. DSS-induced mouse compared alone, showed a better ability alleviate weight...
Swertia bimaculata (SB) is a medicinal herb in China having an array of therapeutic and biological properties. This study aimed to explore the attenuating effect SB on carbon tetrachloride (CCl4) induced hepato-toxicity by regulation gut microbiome ICR mice. For this purpose, CCl4 was injected intraperitoneally different mice groups (B, C, D E) every 4th day for period 47 days. Additionally, D, E received daily dose (50 mg/kg, 100 200 mg/kg respectively) Ether extract via gavage whole...
In this study, a novel ternary complex system (TCS) composed of baicalein, phospholipids, and Soluplus was prepared to improve the flowability dissolution for baicalein phospholipid (BPC). TCS characterized using differential scanning calorimetry (DSC), infrared spectroscopy (IR), powder X-ray diffraction (PXRD), electron microscopy (SEM). The flowability, solubility, oil-water partition coefficient, in vitro dissolution, vivo pharmacokinetics were also evaluated. DSC, IR, PXRD, SEM data...
Abstract Folium Eriobotryae effective fraction (FEA), the extract of Eriobotryae, had been used as anti‐hyperglycemia and anti‐hyperlipemia medicine in China. A previous study indicated that euscaphic acid, maslinic corosolic oleanolic acid ursolic five structurally similar triterpene acids (containing two groups structural isomers), are major components FEA. In present study, we developed a specific reliable LC‐MS method for simultaneous determination rat plasma, further investigated their...
Abstract Objectives To increase the solubility of baicalein (BAI) by preparing BAI-micelles (BAI-M) with Solutol HS15 (HS15) and Poloxamer 188 (F68), thereby improving its oral bioavailability. Methods Baicalein micelles were prepared F68 thin-film dispersion method optimized central composite design (CCD) approach. Physicochemical, in vitro release, Caco-2 cell transport pharmacokinetic studies BAI-M performed. Key findings The optimal formulation showed spherical shape characterization...
UPLC-Q-TOF-MS technology was used to analyze the chemical constituents from classical prescription Huangqi Guizhi Wuwu Tang standard decoction. Acquity HSS T3 column(2.1 mm × 100 mm, 1.8 μm) as chromatographic column, with 0.1% formic acid solution-0.1% acetonitrile mobile phase for gradient elution. The volume flow rate 0.4 mL·min~(-1) and column temperature 40 ℃. Mass spectrometry data of decoction were collected in positive negative ion modes. analyzed identified by Masslynx 4.1 software...
Triterpenoid toosendanin (TSN) exhibits potent cytotoxic activity through inducing apoptosis in a variety of cancer cell lines. However, the target and mechanism apoptotic effects by TSN remain unknown. In this study, we captured specific binding protein HL-60 cells serial affinity chromatography further identified it as deoxycytidine kinase (dCK). Combination direct activation dCK inhibition TSN-induced inhibitor confirmed that is for partially responsible cells. Moreover, was result...
Abstract Objectives We aimed to prepare novel magnolol-loaded mixed micelles (MAG-M) by pluronic F127 and L61 overcome the challenges of magnolol's poor solubility then further improve its oral bioavailability. Methods Magnolol-loaded containing were prepared an organic solvent evaporation method. Physicochemical, transport experiment across Caco-2 cell monolayers pharmacokinetic studies performed characterize MAG-M determine final improvement Key findings The solution was transparent...
The aim of this study was to prepare two novel magnolol (MO)-loaded binary mixed micelles (MO-M) using biocompatible copolymers Soluplus (SOL) and Solutol® HS15 (HS15), SOL d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS), improve magnolol's poor solubility its oral bioavailability. organic solvent evaporation method used obtain MO-M by optimization; one prepared (MO-H), the other TPGS (MO-T). entrapment efficiency (EE%) drug loading (DL%) MO-T were 94.61 ± 0.91% 4.03 0.19%,...
Purpose: We aimed to prepare two oral drug delivery systems consisting of polyoxyl 15 hydroxystearate (HS15) with pluronicF127 (F127) and HS15 pluronicL61 (L61) overcome the challenges genistein's poor bioavailability. This provides a good strategy for enhancing potential value genistein. Methods: designed binary mixed micelle employing organic solvent evaporation method using surfactants (HS15, L61, F127). Formulations (GEN-F GEN-L) were characterized by transmission electron microscopy....
Iron-based nanocarriers have demonstrated potential in redirecting tumor associated macrophages (TAMs) polarization towards the M1 phenotype, critical for activating microenvironment (TME) triple negative breast cancer (TNBC). However, their real-world effectiveness is curtailed by insufficient Fe
An UPLC-Q-TOF-MS method was employed to characterize and classify the chemical components of standard decoction Yiguanjian, a classical famous recipe. Chromatographic separation performed on an Acquity HSS T3(2.1 mm ×100 mm, 1.8 μm) column with mobile phase 0.1% formic acid water-0.1% acetonitrile using gradient elution. The flow rate 0.4 mL·min~(-1) temperature 40 ℃. Mass spectrometry electrospray ionization source(ESI) positive negative ion scanning modes. potential compounds were...