A5101472830- Natural product bioactivities and synthesis
- Medicinal Plant Pharmacodynamics Research
- Traditional Chinese Medicine Analysis
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Healthcare and Venom Research
- Flavonoids in Medical Research
- Inflammasome and immune disorders
- Endoplasmic Reticulum Stress and Disease
- Nanoparticle-Based Drug Delivery
- Fungal Biology and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Sesquiterpenes and Asteraceae Studies
- Neurological Disease Mechanisms and Treatments
- Alkaloids: synthesis and pharmacology
- Medicinal Plants and Neuroprotection
- Phytochemical compounds biological activities
- Natural Compounds in Disease Treatment
- Bioactive natural compounds
- Immunotherapy and Immune Responses
Woosuk University
2025
National Institutes for Food and Drug Control
2024
Nanjing University of Chinese Medicine
2014-2024
Hubei University of Chinese Medicine
2013-2023
Beijing Luhe Hospital Affiliated to Capital Medical University
2023
Jiangsu Provincial Academy of Traditional Chinese Medicine
2013-2022
Second Affiliated Hospital of Nantong University
2014-2021
Nantong University
2014-2021
Affiliated Hospital of Nantong University
2014-2021
China Pharmaceutical University
2012-2018
Abstract: In this study, a novel carbon nanopowder (CNP) drug carrier was developed to improve the oral bioavailability of apigenin (AP). Solid dispersions (SDs) AP with CNP were prepared, and their in vitro release vivo performance evaluated. The physicochemical properties formulations examined by differential scanning calorimetry, X-ray diffraction, electron microscopy. Drug profiles showed that dissolution from CNP-AP system (weight ratio, 6:1) after 60 minutes improved 275% compared pure...
Combination of chemotherapy and immune checkpoint inhibitor therapy has greatly improved the anticancer effect on multiple malignancies. However, efficiency triple-negative breast cancer (TNBC) is limited, since most patients bear "cold" tumors with low tumor immunogenicity. Doxorubicin (DOX), one effective agents, can induce immunogenic cell death (ICD) thus initiating response.In this study, to maximize ICD induced by DOX, chitosan cell-penetrating peptide (R6F3)-modified nanoparticles...
The main purpose of this study was to evaluate the intestinal absorption and antineoplastic effect poorly water-soluble drug celastrol when liposomes were used as oral delivery system. Liposomes prepared by ethanol-injection method. An optimized liposome formulation composed phospholipid, cholesterol Tween-80 resulted in favorable encapsulation efficiency at 98.06 ± 0.94%. Homogeneous stable particle size 89.6 7.3 nm zeta potential −(87.7 5.8) mV determined laser analyzer. Subsequently,...
Rhynchophylline (Rhy) is an alkaloid isolated from Uncaria which has long been recommended for the treatment of central nervous diseases. In our study, neuroprotective effect Rhy was investigated in a stroke model, namely permanent middle cerebral artery occlusion (pMCAO). Rats were injected intraperitoneally once daily four consecutive days before surgery and then received one more injection after surgery. The protein mRNA levels p-Akt, p-mTOR, apoptosis-related proteins (p-BAD cleaved...
Phyllanthus emblica L (PEL), a well-known medical plant, has been used in Asian countries for long time. Increasing evidence suggests that it can prevent the tumorigenesis of cancer associated with nonresolving inflammation. However, possible anti-inflammatory mechanism responsible preventing precancerous lung lesions is not well elucidated.Male A/J mice were randomly divided into 5 groups 10 each group: (1) blank group (saline), (2) benzo(a)pyrene [B(a)P] group, (3) and (4) B(a)P + PEL (5...
Inflammatory microenvironment created by immune cells is favorable for tumor metastasis. Epithelial-mesenchymal transition (EMT) involved in the progression of cancer invasion and metastasis inflammatory microenvironment. In this study, we sought to investigate effects Icariside II, a flavonol glycoside isolated from Epimedium koreanum Nakai, on A549 H1299 migration At non-cytotoxic concentrations, II could inhibit EMT induced LPS-stimulated-THP-1 medium or pro-inflammatory cytokine necrosis...
Paeoniflorin has inhibitory effect on ER stress-associated vascular inflammation.
Cigarette smoking is the main cause of chronic obstructive pulmonary disease and lung cancer. The present study was aimed to explore chemopreventive effect ursolic acid (UA) on these diseases. In CSE treated normal human bronchial epithelial cell model, UA alleviated cytotoxicity caused by CSE, recovered intracellular redox balance, relieved stimulation external deleterious factors as well. mitigated CSE-induced DNA damage through Nrf2 (nuclear factor erythroid 2-related 2) pathway....