A5064531499- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Metabolism, Diabetes, and Cancer
- Renal cell carcinoma treatment
- Renal and related cancers
- Plant-based Medicinal Research
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Natural Antidiabetic Agents Studies
- Berberine and alkaloids research
- Circular RNAs in diseases
- Gut microbiota and health
- Renal Diseases and Glomerulopathies
- Pancreatic function and diabetes
- Alkaloids: synthesis and pharmacology
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
- Advanced Glycation End Products research
Hebei Medical University
2012-2025
Second Hospital of Hebei Medical University
2012-2025
Nanjing University of Chinese Medicine
2015-2024
Wannan Medical College
2018-2020
Jiangsu Provincial Academy of Traditional Chinese Medicine
2013-2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2017
Anhui Provincial Hospital
2013-2016
Anhui Medical University
2013-2016
China Academy of Chinese Medical Sciences
2015
Abstract Cuproptosis, a newly discovered programmed cell death induced by copper ions, is associated with the progression and drug resistance of various tumors. Docetaxel plays vital role as first‐line chemotherapeutic agent for advanced prostate cancer; however, most patients end up cancer because inherent or acquired resistance. Herein, we examined cuproptosis in to docetaxel. We treated lines elesclomol–CuCl 2 , well performed analyses CCK8, colony formation tests, cycle flow assay,...
Docetaxel-based chemotherapy failure in advanced prostate carcinoma has partly been attributed to the resistance of cancer (PC) cells docetaxel-induced apoptosis. Hence, there is an urgent need identify mechanisms docetaxel chemoresistance and develop new combination therapies. miR-193a-5p level was evaluated by qPCR tissues cell lines, its expression also examined situ hybridization. PC line (PC3 cell) transfected with mimic or inhibitor, then apoptosis downstream genes Bach2 HO-1 were...
Colorectal cancer has become one of the leading cause morbidity and mortality throughout world. Hederagenin, a derivative oleanolic acid isolated from leaves ivy (Hedera helix L.), been shown to have potential anti-tumor activity. The study was conducted evaluate whether hederagenin could induce apoptosis human colon LoVo cells explore possible mechanism. MTT assay used for evaluating cell viability while Annexin V-FITC/PI Hoechst 33342 nuclear stainining were determination mitochondrial...
Paeoniflorin has inhibitory effect on ER stress-associated vascular inflammation.
P. polyphylla Smith var. chinensis (Franch.) Hara (PPSCFH) has been used as medicinal Paris for the prevention and treatment of cancers in China thousands years. Its main components, steroidal saponins (PRS), have confirmed to inhibit tumor growth. In present study, immunostimulation PRS was investigated Lewis bearing-C57BL/6 mice while induction apoptosis A549 cells also studied. The with (2.5, 5.0 7.5 mg/kg) significantly inhibited tumor, volume, weight C57BL/6 mice. rates inhibition (at...
Androgen deprivation therapy is the primary strategy for treatment of advanced prostate cancer; however, after an initial regression, most patients will inevitably develop a fatal androgen-independent tumor. Therefore, understanding mechanisms transition to androgen independence cancer critical identify new ways treat older who are ineligible conventional chemotherapy. The effects 5-Aza-2’-deoxycytidine (5-Aza-CdR) on viability and apoptosis androgen-dependent (LNCaP) (PC3) cell lines were...
A flavonoid fraction of Herba Epimedii, including eight glycoside compounds, epimedoside A, ikarisoside F, baohuoside II, sagittatoside B, 7-O-rhamnosyl icariside 2″-O-rhamnosyl and I, was isolated prepared from the leaves Epimedii. This study conducted to assess potential effect Epimedii on osteoporosis in ovariectomized rats. Rats received repeated administration a vehicle (ovariectomized), (7.5, 15, 30 mg/kg/d), ipriflavone (200 mg/kg/d) once day for 8 weeks, beginning 4 weeks after...
Previous studies found that metformin provided some renoprotection for diabetic renal damage. In the present study, we evaluated effects of different doses on expression tissue nephrin in type 2 diabetes mellitus (T2DM) model rats and possible mechanism underlying its protective effect kidney podocytes.A high-fat diet combined with a low dose streptozotocin was used to induce T2DM rats. Diabetic were treated 150, 300, or 500 mg/kg 8 weeks. At end urine blood samples collected measurement...
Abstract Splicing factor 3B subunit 4 (SF3B4) plays important functional roles not only in pre-mRNA splicing, but also the regulation of transcription, translation, and cell signaling, its dysregulation contributes to various diseases including Nager syndrome tumorigenesis. However, role SF3B4 underlying mechanisms clear renal carcinoma (ccRCC) remain obscure. In present study, we found that expression was significantly elevated ccRCC tissues negatively correlated with overall survival...
SIRT1 and FOXO1 play an important role in the pathogenesis of diabetic nephropathy (DN). However, association between genetic polymorphisms susceptibility to type 2 DN (T2DN) has not been explored. In this study, a total 1066 patients with diabetes mellitus (T2DM) (413 without 653 DN) were enrolled. The genotypes three htSNPs (rs3818292, rs4746720, rs10823108) within two (rs2721068, rs17446614) determined by PCR-RFLP. HbA1C, LDL, HDL, TC, TG levels also examined. rs10823108 AA genotype was...
Background The renoprotective mechanisms of adenosine monophosphate (AMP)-activated protein kinase (AMPK) agonist - metformin have not been stated clearly. We hypothesized that may ameliorate inflammation via AMPK interaction with critical inflammatory cytokines. aim this study was to observe the effects on expression nuclear factor-κB (NF-κB), monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1) and transforming growth factor-beta 1 (TGF-β1) induced by high...
The migration and invasion of lung cancer cells into the extracellular matrix contributes to high mortality rates cancer. protein kinase C (PKC) downstream signaling pathways are important in cells. Calycosin (Cal), an effector chemical from Astragalus has been reported affect recurrence metastasis via regulation expression metalloproteinases (MMPs). inhibition Cal on A549 was investigated present study. Cell viability apoptosis assays were performed using MTT flow cytometric analyses. A...
Sunitinib has been used as the main therapy to treat metastatic clear cell renal carcinoma (ccRCC) it could function via suppressing tumor growth and angiogenesis. Yet most ccRCC tumors may still regrow due development of sunitinib-resistance, detailed mechanisms remain be further investigated. The angiopoietin family includes angiopoietin-1 angiopoietin-2 (ANGPT-1 -2). It was reported that estradiol regulates expression ANGPT-1, but not ANGPT-2, through estrogen receptor α (ERα) in an...
Alterations in the gut microbiome and bile acid metabolism are known to play a role development progression of colon cancer. Medicinal plants like Astragalus mongholicus Bunge Curcuma aromatica Salisb. (AC) have shown preferable therapeutic effect on cancer therapy, especially digestive tract tumors However, precise mechanisms AC inhibiting cancer, particularly relation dynamics, not fully understood. Our research aimed investigate anti-tumor properties mice with CT26 further its underlying...
Ganoderma luncidum (Leyss. ex Fr.) Karst. (GLK) has been used traditionally for the prevention and treatment of cancers or tumors a long time in Traditional Chinese Medicine. The triterpenes as main effective components GLK have found to be beneficial efficacy. purpose this study was examine anti-lung cancer activity vitro vivo explore their effects potential mechanisms. A549 cells Lewis tumor-bearing mice were evaluate inhibition on cell proliferation tumor growth. IC50 24.63 μg/mL....
Podocalyxin (PCX) is a signature molecule of the glomerular podocyte and maintaining integrity filtration function glomerulus. The aim this study was to observe effect different doses metformin on renal tissue PCX expression in type 2 diabetic rats clarify its protection podocytes. Type Sprague-Dawley (SD) which diabetes induced by high-fat diet/streptozotocin (HFD-STZ) were treated with (150, 300, 500 mg/kg per day, resp.) for 8 weeks. Various biochemical parameters, kidney histopathology,...
Tumor vascular normalization involved in immune response is beneficial to the chemotherapy of tumors. Recombinant human endostatin (Endostar), an angiogenesis inhibitor, has been demonstrated be effective hepatocellular cancer (HCC). However, its HCC and role were unclear. In present study, effects Endostar on tumor evaluated hepatoma 22 (H22) tumor-bearing mice. was able inhibit proliferation infiltration cells improve α-fetoprotein, necrosis factor-α cyclic adenosine 5'-phosphate levels...
The drug pair consisting of Sophora flavescens Aiton ( Sophorae flavescentis radix , Kushen) and Coptis chinensis Franch. Coptidis rhizoma Huanglian), as described in Prescriptions for Universal Relief (Pujifang), is widely used to treat laxation. Matrine berberine are the major active components Kushen Huanglian, respectively. These agents have shown remarkable anti-cancer anti-inflammatory effects. A mouse model colorectal cancer was determine most effective combination Huanglian against...