A5055087976- Heavy Metal Exposure and Toxicity
- Heavy metals in environment
- Arsenic contamination and mitigation
- Mercury impact and mitigation studies
- Air Quality and Health Impacts
- Trace Elements in Health
- RNA and protein synthesis mechanisms
- Noise Effects and Management
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Glycation End Products research
- Genomics, phytochemicals, and oxidative stress
- Selenium in Biological Systems
- Nanomaterials and Printing Technologies
- Food Supply Chain Traceability
- Contact Dermatitis and Allergies
- Meat and Animal Product Quality
- Nanowire Synthesis and Applications
- Anodic Oxide Films and Nanostructures
- Plasmonic and Surface Plasmon Research
- Genomics and Chromatin Dynamics
- Chromium effects and bioremediation
- Aluminum toxicity and tolerance in plants and animals
- Radioactivity and Radon Measurements
- PI3K/AKT/mTOR signaling in cancer
- Fluid Dynamics and Thin Films
Nanjing Agricultural University
2021-2025
Ministry of Industry and Information Technology
2023
Collaborative Innovation Center of Advanced Microstructures
2016-2022
Nanjing University
2009-2022
Columbia University
2019-2022
Zhejiang University
2022
Ministry of Agriculture and Rural Affairs
2021
State Key Laboratory of Pollution Control and Resource Reuse
2009-2020
Jiangsu Provincial Academy of Traditional Chinese Medicine
2016
Beijing University of Chemical Technology
2012
Cadmium (Cd) is a toxic and carcinogenic pollutant widely distributed in the environment. Dietary intake main source of Cd exposure for nonsmoking population. Assessment dietary provides pathway to predict body burden potential health effects. Kidney has been considered as most sensitive target chronic exposure. Because proportional relationship between accumulation kidney excretion via urine, urinary (UCd) used biomarker Here, we review levels different countries, summarize global food...
Ingestion of metal-contaminated soils poses risks to human health. To accurately assess the risks, in vitro assays have been developed measure metal bioaccessibility. However, they often differ considerably gastrointestinal fluid components and assay parameters, leading inconsistent bioaccessibility results. As such, need be validated against vivo bioassays based on vivo-in correlations (IVIVCs). help researchers select best increase robustness IVIVCs, there is a review compile existing...
Dietary Cd intake is often estimated without considering bioavailability. Measured urinary for a cohort of 119 nonsmokers with rice as staple was compared to predicted values from rice-Cd and relative bioavailability (RBA) in based on steady state mouse kidney bioassay toxicokinetic model. The geometric mean (GM) β2-microglobulin 1.08 234 μg g-1 creatinine. Applying Cd-RBA foods aggregate (41.5 ± 12.4, 48.0 9.3, 48.8 21.3% rice, wheat, vegetables), the largest contributor (71%). For 63...
A steady-state mouse model was developed to determine arsenic (As) relative bioavailability (RBA) in rice refine As exposure humans. Fifty-five samples from 15 provinces of China were analyzed for total As, with 11 cooked speciation and assessment. Arsenic concentrations 38-335 μg kg-1, averaging 133 AsIII being dominant (36-79%), followed by DMAV (18-58%) AsV (0.5-16%). Following oral doses individual species mice at low (2.5-15 per mouse) over a 7-d period, strong linear correlations (R2 =...
Hexavalent chromium (Cr(VI)) is much more toxic and mobile than the trivalent species (Cr(III)) consequently, in situ monitoring of Cr(VI) can improve understanding Cr biogeochemistry toxicity ecosystems. The passive diffusive gradients thin-films (DGT) technique a powerful tool for determining metal(loid) speciation, but binding phase that absorbs only one specific needed. N-Methyl-d-glucamine (NMDG) functional resin was incorporated into DGT selective measurement Cr(VI). This NMDG-DGT...
To determine the effectiveness of mineral dietary supplements to modulate cadmium (Cd) exposure, an in vivo mouse bioassay was conducted Cd relative bioavailability (Cd-RBA) Cd-contaminated rice (0.80 mg kg-1) with and without Zn, Fe, or Ca as nitrate chloride salts. Without supplements, Cd-RBA 43 ± 5.3% based on average accumulation liver plus kidneys end point. Among Ca(NO3)2, Zn(NO3)2, Fe(NO3)2 150-5000 kg-1 most effective reducing by 31-80% 8.5-29%, while 30-200 Zn ineffective, being...
Using in vitro bioaccessibility assays to predict Pb relative bioavailability (RBA) contaminated soils has been demonstrated, however, limited research was performed on urban having lower levels. In this study, 162 from parks 27 capital cities China were measured for using the SBRC assay, with Pb-RBA 38 subsamples being a mouse-kidney assay. Total concentrations 9.3-1198 mg kg(-1), 92% of <100 kg(-1). Lead 20-94%, increasing concentration up 100 kg(-1) (r = 0.44), variability (60-80%)...
Recent studies have investigated lead (Pb) concentrations in lip products but little is known about its oral bioavailability. In this study, 75 lipsticks and 18 glosses were assessed for Pb concentration, while 15 samples relative bioavailability (RBA, to acetate absorption) using a mouse femur assay. Lead 0.2–10 185 mg kg–1, with 21 exceeding the Chinese limit of 40 kg–1. Samples orange pink colors and/or low cost contained higher concentrations. For > 7500 was present due addition chromate...
Mushrooms accumulate arsenic (As), yet As concentrations, speciation, and localization in cultivated mushrooms across a large geographic distribution are unknown. We characterized 141 samples of nine species from markets capital cities China, with Lentinula edodes, Pleurotus ostreatus, Agaricus bisporus being analyzed for speciation localization. Total concentrations ranged 0.01 to 8.31 mg kg–1 dw, A. (0.27–2.79 kg–1) containing the most followed by P. ostreatus L. edodes (0.04–8.31...
Currently, no effective and safe medicines are available to treat diabetic nephropathy (DN). Bardoxolone methyl (CDDO-Me) has displayed promising anti-DN activity as well serious side effects in clinical trials, probably because the highly reactive α-cyano-α,β-unsaturated ketone (CUK) ring A of CDDO-Me can covalently bind thiol functionalities many biomacromolecules. In this study, we designed synthesized a γ-glutamyl transpeptidase (GGT)-based CUK-modified derivative (2) address issue. 2 be...
Bile acids (BAs) have recently emerged as important regulators of many physiological and pathological processes. However, the change colonic BAs induced by high-fat diet (HFD) their effects on barrier function remain to be further elucidated.C57BL/6 mice are divided into two groups feed 12 weeks with diets differing for fat content. Higher levels serum diamine oxidase (DAO) activity, endotoxin (ET), d-lactate (d-LA) observed in HFD-fed mice, indicating an increase intestinal permeability....