A5009620553- Advanced biosensing and bioanalysis techniques
- Genomics, phytochemicals, and oxidative stress
- Electrochemical sensors and biosensors
- Advanced Nanomaterials in Catalysis
- Enzyme Catalysis and Immobilization
- Pharmacological Effects of Natural Compounds
- Biosensors and Analytical Detection
- Proteins in Food Systems
- Seaweed-derived Bioactive Compounds
- Ginseng Biological Effects and Applications
- Phytochemicals and Antioxidant Activities
- Metal-Organic Frameworks: Synthesis and Applications
- Free Radicals and Antioxidants
- Echinoderm biology and ecology
- RNA Interference and Gene Delivery
- Analytical Chemistry and Chromatography
- Carbon and Quantum Dots Applications
- DNA and Nucleic Acid Chemistry
- Food Chemistry and Fat Analysis
- Postharvest Quality and Shelf Life Management
- Radioactive element chemistry and processing
- Curcumin's Biomedical Applications
- Luminescence and Fluorescent Materials
- Synthesis and biological activity
- Plant Stress Responses and Tolerance
Beijing University of Chemical Technology
2016-2025
Hebei Agricultural University
2022-2025
Wuhan University of Technology
2025
University of South China
2019-2024
Institute of Special Animal and Plant Sciences
2021-2024
Chinese Academy of Agricultural Sciences
2024
Northwest Normal University
2021-2024
Beijing Academy of Agricultural and Forestry Sciences
2023-2024
Henan Provincial People's Hospital
2024
Ministry of Agriculture and Rural Affairs
2023-2024
A novel dual-activatable fluorescence/MRI bimodal platform is designed for tumor cell imaging by using a redoxable manganese dioxide (MnO2) nanosheet-aptamer nanoprobe. The MnO2 nanosheet acts as DNA nanocarrier, fluorescence quencher, and intracellular glutathione (GSH)-activated MRI contrast agent. In the absence of target cells, neither signaling nor nanoprobe activated. presence binding aptamers to their targets weakens adsorption on nanosheets, causing partial recovery, illuminating...
Using nanomaterials to achieve functional enzyme mimics (nanozymes) is attractive for both applied and fundamental research. Laccases are multicopper oxidases highly important biotechnology environmental remediation. In this work, we report an exceptionally simple yet laccase mimic based on guanosine monophosphate (GMP) coordinated copper. It forms amorphous metal-organic framework (MOF) material. The ratio of copper GMP 3:4 as determined by isothermal titration calorimetry. has excellent...
ConspectusDNA performs a vital function as carrier of genetic code, but in the field nanotechnology, DNA molecules can catalyze chemical reactions cell, that is, DNAzymes, or bind with target-specific ligands, aptamers. These functional DNAs different modifications have been developed for sensing, imaging, and therapeutic systems. Thus, hold great promise future applications nanotechnology bioanalysis. However, these face challenges, especially biomedicine. For example, typically require use...
DNA molecular machines show great promise in fields such as biomarker discovery and biological activity regulation, but operating with specific functions within living systems remains extremely challenging. Although have been engineered exact molecular-level specifications, some intrinsic imperfections poor cell permeation fragility complex cytoplasmic milieu persist due to the well-established character of nucleic acid molecules. To circumvent these problems, we herein report a molecularly...
Accurate detection and imaging of tumor-related mRNA in living cells hold great promise for early cancer detection. However, currently, most probes designed to image intracellular confront intrinsic interferences arising from complex biological matrices resulting inevitable false-positive signals. To circumvent this problem, an DNA nanoprobe, termed tetrahedron nanotweezer (DTNT), was developed reliably based on the FRET (fluorescence resonance energy transfer) "off" "on" signal readout...
In this article, we used an artificial DNA base to manipulate the formation of nanoflowers (NFs) easily control their sizes and functionalities. Nanoflowers have been reported as noncanonical self-assembly multifunctional nanostructures, assembled from long building blocks generated by rolling circle replication (RCR). They could be incorporated with myriad functional moieties. However, efficacy these NFs potential nanocarriers delivering cargo in biomedicine is limited bioavailability...
Functional nucleic acid (FNA)-based sensing systems have been developed for efficient detection of a wide range biorelated analytes by employing DNAzymes or aptamers as recognition units. However, their intracellular delivery has always concern, mainly in efficiency, kinetics, and the amount delivered FNAs. Here we report DNA dendrimer scaffold an nanocarrier to deliver FNAs conduct situ monitoring biological molecules living cells. A histidine-dependent DNAzyme anti-ATP aptamer were chosen...
Noble metals, especially gold, have been widely used in plasmon resonance applications. Although silver has a larger optical cross section and lower cost than it attracted much less attention because of its easy corrosion, thereby degrading plasmonic signals limiting To circumvent this problem, we report the facile synthesis superstable AgCu@graphene (ACG) nanoparticles (NPs). The growth several layers graphene onto surface AgCu alloy NPs effectively protects Ag from contamination, even...
Zn<sup>2+</sup> and AMP forming coordination hydrogel nanofibers, encapsulating multiple enzymes under mild conditions with high activity stability.
AMP is coordinated with Zn<sup>2+</sup> forming supramolecular gels that can be mechanically healed and trap guest molecules.
Abstract Using nanomaterials to develop multimodal systems has generated cutting-edge biomedical functions. Herein, we a simple chemical-vapor-deposition method fabricate graphene-isolated-Au-nanocrystal (GIAN) nanostructures. A thin layer of graphene is precisely deposited on the surfaces gold nanocrystals enable unique capabilities. First, as surface-enhanced-Raman-scattering substrates, GIANs quench background fluorescence and reduce photocarbonization or photobleaching analytes. Second,...