A5100425560- Alzheimer's disease research and treatments
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Advanced Glycation End Products research
- Acute Myeloid Leukemia Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolism and Genetic Disorders
- Retinoids in leukemia and cellular processes
- Iron Metabolism and Disorders
- Neurological Disease Mechanisms and Treatments
- Apelin-related biomedical research
- Blood Coagulation and Thrombosis Mechanisms
- Acute Lymphoblastic Leukemia research
- Amyotrophic Lateral Sclerosis Research
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- Immune Response and Inflammation
- Hemoglobinopathies and Related Disorders
- Asthma and respiratory diseases
- Neurogenetic and Muscular Disorders Research
- Platelet Disorders and Treatments
- Nuclear Receptors and Signaling
- Histiocytic Disorders and Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Institute of Laboratory Animal Science
2015-2025
Yeungnam University
2025
Institute of Hematology & Blood Diseases Hospital
2011-2024
Peking Union Medical College Hospital
2014-2024
Nanjing General Hospital of Nanjing Military Command
2022-2024
Wuhan University of Technology
2024
Nanjing University
2024
Xinjiang Medical University
2019-2024
Fifth Affiliated Hospital of Xinjiang Medical University
2019-2024
Abstract Background It is known that amyloid-β peptide (Aβ) plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). Interaction between Aβ and receptor for advanced glycation end products (RAGE) has been implicated neuronal degeneration associated with this disease. Pinocembrin, flavonoid abundant propolis, reported to possess numerous biological activities beneficial health. Our previous studies have demonstrated pinocembrin neuroprotective effects on ischemic vascular...
The Amyloid-β (Aβ)-induced impairment of hippocampal synaptic plasticity is an underlying mechanism memory loss in the early stages Alzheimer's disease (AD) human and mouse models. inhibition calcium/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation plays important role long-term memory. In this study, we isolated naringin from Pomelo peel (a Citrus species) studied its effect on APPswe/PS1dE9 transgenic model AD. Three-month-old mice were randomly assigned to a vehicle...
Activated protein C (APC), the only FDA-approved biotherapeutic drug for sepsis, possesses anticoagulant, antiinflammatory, and barrier-protective activities. However, mechanisms underlying its anti-inflammatory functions are not well defined. Here, we report that antiinflammatory activity of APC on macrophages is dependent integrin CD11b/CD18, but endothelial receptor (EPCR). We showed CD11b/CD18 bound within specialized membrane microdomains/lipid rafts facilitated cleavage activation...
The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment dyspepsia and various inflammatory diseases. In present study, we evaluated potential radical scavenging capacity, activity against nitrous oxide, cytokines production neuramindase (NA) its isolates. results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH NA with IC50 values 1.02 mg/mL 1.27 respectively, quercetin (2) also significant action NA, 3.82 1.90 mg/mL....
This study aims to explore the effects of exercise on postmenopausal osteoporosis and mechanisms by which affects bone remodeling. Sixty-three Wistar female rats were randomly divided into five groups: (1) control group, (2) sham-operated (3) OVX (Ovariectomy) (4) DES-OVX (Diethylstilbestrol-OVX) (5) Ex-OVX (Exercise-OVX) group. The rat model was established through ovariectomy. made run 251.2 meters every day, 6 d/wk for 3 months in a running wheel. Trabecular volume (TBV%), total...
Abstract Background Tripartite motif (TRIM46) is a relatively novel protein that belongs to tripartite family. TRIM46 organizes parallel microtubule arrays on the axons, which are important for neuronal polarity and axonal function. highly expressed in brain, but its biological function adults has not yet been determined. Results Trim46 knockout (KO) rat line was established using CRISPR/cas9. KO rats had smaller hippocampus sizes, fewer dendritic arbors spines, shorter more distant axon...
Objectives This study aimed to evaluate the clinical performance of plasma cell-free DNA (cfDNA) next-generation sequencing (NGS) for pathogen detection in patients with sepsis. Methods A total 43 pairs blood and samples form 33 culture-positive were used as testing metagenomic NGS (mNGS) 16S ribosomal RNA gene amplicons (16S rRNA NGS). The results routine tests, including microbial culture, complete count, biochemical collected from electronic medical records. Results Using an mNGS sample,...
Abstract Background Liver diseases are a major contributor to both morbidity and mortality. Conditional knockout animals always produced through crossing floxed with tissue‐specific Cre animal. The use of rat resource has rapidly increased, but the liver‐specific lines for studying liver interested genes limited, especially in spatially temporally restricted manner. Methods RNA sequencing real‐time polymerase chain reaction (PCR) were used screen confirm presence genes. Apoa4 ‐Cre rats...
The use of cytarabine (Ara-C) in treating acute promyelocytic leukemia (APL) is controversial. This study was conducted to demonstrate the effect treatment with or without Ara-C on long-term event-free survival (EFS) overall (OS). All patients received all-trans retinoic acid (ATRA) + arsenic trioxide (ATO) induction therapy, followed by course idarubicin (IDA) and ATO, then were randomly allocated 2 groups for consolidation daunorubicin (DNR) group DNR, DNR (DA) Ara-C. Maintenance therapy...
The rat is an important laboratory animal for physiological, toxicological and pharmacological studies. Clustered regularly interspaced short palindromic repeats ( CRISPR )/CRISPR‐associated 9 (Cas9) a simple efficient tool to generate precise genetic modifications in rats, which will promote the accumulation of resources enable more studies gene function. To monitor Cre– loxP ‐mediated excision vivo , we generated Cre reporter strain Rosa26‐imCherry ) by knockin cassette at Rosa26 locus...
Cytochrome P450 2E1 (CYP2E1) is an effective generator of reactive oxygen species. Marked expression CYP2E1 occurs in the heart and it known to be regulated course progression myocardial ischemia cardiomyopathy. We provide evidence that strongly up-regulated cTnT(R141W) transgenic mice with dilated Heart tissue-specific were produced study effects overexpression on heart. Increased mortality, chamber dilation contractile dysfunction, as well myocyte disarray, interstitial fibrosis,...
Hyperbaric oxygen (HBO) and Ginkgo biloba extract (e.g., EGB 761) were shown to ameliorate cognitive memory impairment in Alzheimer's disease (AD). However, the exact mechanism remains elusive. The aim of present study was investigate possible mechanisms HBO 761 via function nuclear factor kappa-B (NF-κB) pathway.
Although electroconvulsive therapy (ECT) is one of the most effective treatments for major depressive disorder (MDD), mechanism underlying therapeutic efficacy and side effects ECT remains poorly understood. Here, we investigated alterations in cortical morphological measurements including thickness (CT), surface area (SA), local gyrification index (LGI) 23 MDD patients before after ECT. Furthermore, multivariate pattern analysis using linear support vector machine (SVM) was applied to...