A5100457268- Shoulder and Clavicle Injuries
- Tea Polyphenols and Effects
- Shoulder Injury and Treatment
- Cardiac Ischemia and Reperfusion
- Immune Cell Function and Interaction
- Electron Spin Resonance Studies
- Trigeminal Neuralgia and Treatments
- Temporomandibular Joint Disorders
- Iron Metabolism and Disorders
- Lymphoma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Orthopaedic implants and arthroplasty
- Chemotherapy-induced cardiotoxicity and mitigation
- Oropharyngeal Anatomy and Pathologies
- HER2/EGFR in Cancer Research
- Dental Implant Techniques and Outcomes
- Heavy Metals in Plants
- Dietary Effects on Health
- Luminescence Properties of Advanced Materials
- Enhanced Recovery After Surgery
- Ginseng Biological Effects and Applications
- Chemokine receptors and signaling
- Bariatric Surgery and Outcomes
- Curcumin's Biomedical Applications
- Medical Imaging and Analysis
Shanghai University of Traditional Chinese Medicine
2023-2025
Shanxi Medical University
2021-2024
Jiaxing University
2024
Second Hospital of Shanxi Medical University
2021-2024
Third Hospital of Hebei Medical University
2018-2023
Hebei Medical University
2018-2023
Shantou University
2023
Shantou University Medical College
2023
Fujian Medical University
2022
First Affiliated Hospital of Xi'an Jiaotong University
2022
Abstract Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by cardiotoxicity. However, the underlying mechanisms remain to be fully elucidated. In this study, we tested whether NADPH oxidase 2 (Nox2) mediates cardiac sympathetic nerve terminal abnormalities and myocyte autophagy, resulting in atrophy dysfunction doxorubicin-induced heart failure. Nox2 knockout (KO) wild-type (WT) mice were randomly assigned receive single injection of...
Foxp3+ regulatory T (Treg) cells, as one of the subtypes CD4+ are crucial gatekeeper in pathogenesis self-antigen reactive diseases. In this context, we demonstrated that selective ablation early growth response gene 1 (Egr-1) cells exacerbated experimental autoimmune encephalomyelitis (EAE) murine models. The absence Egr-1 obtained from EAE mice and naïve impeded differentiation influence Treg. Importantly, multiple sclerosis patients, both Foxp3 were found to decrease. Further studies...
Background: This study aimed to estimate peripheral blood lymphocyte subsets and programmed death receptor-1 positive (PD-1+) proportions of T cells, their impact on progression free survival (PFS) radiological response in lung cancer.Methods: From May 2018 April 2020, 34patients the Henan Tumor Hospital who were diagnosed with advanced cancer recruited this study. Peripheral PD-1+ cells assessed by flow cytometry before after treatment immune checkpoint inhibitors (ICIs). The associations...
To determine if TSPAN1 overexpression is associated with clinicopathological and prognostic factors in human colorectal adenocarcinoma.Total RNA was extracted 20 adenocarcinoma tissues for mRNA assay by RT-PCR. Eighty-eight specimens of were surgically removed. protein levels cancer determined immunohistochemistry using a polyclonal antibody against self-prepared TSPAN1. The correlation between expression the overall survival rate analyzed univariate multivariate assay.TSPAN1 detected 90.0%...
Cytochrome P450 2E1 (CYP2E1) is an effective generator of reactive oxygen species. Marked expression CYP2E1 occurs in the heart and it known to be regulated course progression myocardial ischemia cardiomyopathy. We provide evidence that strongly up-regulated cTnT(R141W) transgenic mice with dilated Heart tissue-specific were produced study effects overexpression on heart. Increased mortality, chamber dilation contractile dysfunction, as well myocyte disarray, interstitial fibrosis,...
BACKGROUND:The aims of this preliminary study were to evaluate contrast-enhanced ultrasound (CEUS) imaging and the therapeutic response enlarged superficial lymph nodes in patients with lymphoma before after chemotherapy determine most useful CEUS parameters. MATERIAL AND METHODS:Forty-three lymphoma, 43 nodes, underwent conventional (US), treatment first three cycles chemotherapy. Clinical responses included overall (OR) no (NR). Imaging parameters by time-intensity curve (TIC) basic...
Doxorubicin (DOX) is one of the most effective chemotherapeutic agents for treatment a number malignancies. However, its use limited by serious cardiotoxic effects, which there are currently no reliable pharmacologic therapies. Estrogen has exhibited protective effects against cardiac stressors in male and female animal models; however, on DOX‑induced cardiotoxicity remain unknown. High mortality morbidity rates have been observed patients with cancer worldwide, DOX often administered to...
This study aimed to investigate the changes in chemical composition content, and biological activity of Cornus officinalis before after simulated digestion vitro. The results showed that iridoid glycosides C. were less stable than phenols gastrointestinal stage. After colonic fermentation simulation, almost completely decomposed. However, content phenolic compounds was significantly increased, especially contents gallic acid, catechin, epicatechin, benzoic acid. Moreover, fermentation,...
The aim of the present study was to explore a disintegrin and metalloproteinase 17 (ADAM17) mRNA protein expression in esophageal squamous cell carcinoma its association with clinicopathological factors prognosis. Through semi‑quantitative reverse transcription polymerase chain reaction, ADAM17 50 cases corresponding normal mucosa were detected. Using streptavidin peroxidase conjugated immunohistochemistry, levels detected 80 mucosa. A log rank test Cox proportional hazards model used for...
Cereal vinegar sediment (CVS) is a natural precipitate formed during the aging process of traditional grain vinegar. It has been used as Chinese medicine, while its composition and function are reported minimally. In this study, we measured CVS in terms saccharide, protein, fat water content, polyphenol flavonoid content. Furthermore, determined amino acids, organic other soluble metabolites using reverse-phase high-performance liquid chromatography (RP-HPLC), HPLC, with tandem mass...
Lethal ventricular arrhythmia‑sudden cardiac death (LVA‑SCD) occurs frequently during the early stage of myocardial ischemia (MI). However, mechanism underlying higher LVA‑SCD incidence is still poorly understood. The present study aimed to explore role mitochondrial reactive oxygen species (mROS) and Ca2+ crosstalk in promoting MI. RyR2 S2814A mice their wild‑type littermates were used. MitoTEMPO was applied scavenge ROS (mROS). Mice subjected severe MI occurrence evaluated. Levels calcium...
Objective The treatment of osteoporotic fractures is difficult, and to minimize the negative result or poor functional rehabilitation, this study focuses on hydrogen water (HRW) test its effect process menopausal fracture healing relationship with autophagy try reveal potential mechanism action HRW fractures. Materials methods A rat model was established, systematically applied without 3MA. results were analyzed X-rays, micro-CT scans, serum biomarker analysis, biomechanical tests,...
Research on proximal fractures in the humeral bicipital groove (BG), a region which bones are not commonly fractured, is considered sparse literature. The objective of this research was to present definite characteristics and distribution BG fractures.This retrospective study included enrolled 119 adult patients with complete radiography data identify fracture from January 2021 August 2021. divided into three parts, i.e. upper 1/3, middle lower 1/3 BG, lines transcribed male or female...
Primary trigeminal neuralgia (PTN) is characterized by chronic neuropathic pain. There are few studies exploring masticatory muscle changes in patients with PTN. This study evaluated the muscles using magnetic resonance imaging (MRI) and predictive factors of The radiologic outcomes 52 PTN 58 healthy adults were evaluated. temporalis, lateral pterygoid, medial masseter assessed MRI. Atrophy edema noted. Multivariate analyses conducted to identify associated atrophy. Among group, right side...
Triple-negative breast cancer (TNBC) is highly aggressive, with high rates of early relapse and very poor overall prognosis. Amphiregulin (AREG) the most abundant epidermal growth factor receptor (EGFR) agonist in MDA-MB-231 TNBC cells, whose proliferation can be inhibited by (–)-epigallocatechin gallate (EGCG), a constituent green tea that prone to oxidative polymerization. The effect dimeric-EGCG, dimer oxidized polymerized EGCG, on cell warrants further exploration. In present study, MTT,...