A5111011089- Gut microbiota and health
- Immune cells in cancer
- Telomeres, Telomerase, and Senescence
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Alkaloids: synthesis and pharmacology
- Epigenetics and DNA Methylation
- Berberine and alkaloids research
- Cancer Mechanisms and Therapy
- Chromatography in Natural Products
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Single-cell and spatial transcriptomics
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Iron Metabolism and Disorders
- Diet and metabolism studies
- Protein Tyrosine Phosphatases
- Bioactive natural compounds
- Plant biochemistry and biosynthesis
- Traditional Chinese Medicine Analysis
- Ferroptosis and cancer prognosis
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
Nanjing University of Chinese Medicine
2022-2025
Nanjing University
2024
The Synergetic Innovation Center for Advanced Materials
2023
Colorectal cancer (CRC) remains the third most common tumor worldwide. Ulcerative colitis (UC) could cause chronic inflammation and ulcers in colon rectum. UC is a risk factor for high incidence of CRC, UC-associated CRC (UC-CRC) still increasing. Chinese medicine prescription, Xian-Lian-Jie-Du decoction (XLJDD), has been proven its efficacy some UC-CRC patients. However, mechanism XLJDD treating unknown. This study aimed to investigate UC-CRC.We constructed an AOM/DSS mouse model that...
Abstract Background Shen-Bai-Jie-Du decoction (SBJDD), a traditional Chinese herb formula developed based on evidence-based medicine, is efficacy to reduce the recurrence and carcinogenesis of colorectal adenoma. However, mechanism SBJDD treat adenoma remains unclear. The present study aims investigate from aspects regulating gut microbiota short-chain fatty acids (SCFAs). Methods Twenty-one patients diagnosed with were recruited in required take for four consecutive weeks. Analysis was...
The drug pair consisting of Sophora flavescens Aiton ( Sophorae flavescentis radix , Kushen) and Coptis chinensis Franch. Coptidis rhizoma Huanglian), as described in Prescriptions for Universal Relief (Pujifang), is widely used to treat laxation. Matrine berberine are the major active components Kushen Huanglian, respectively. These agents have shown remarkable anti-cancer anti-inflammatory effects. A mouse model colorectal cancer was determine most effective combination Huanglian against...
The Src homology 2 domain-containing tyrosine phosphatase (SHP2) is a non-receptor and acts as convergent node for oncogenic cell-signaling cascades. SHP2 has been recognized breakthrough anti-tumor therapeutic target. However, it still elusive the role of in manipulating tumor microenvironment malignancy. Here, we found that activation tumor-associated macrophages (TAMs) paralleled mammary carcinoma progression. Co-culture system human breast cancer specimens also showed high levels...
Sorting nexin 10 (SNX10) has recently been identified as a critical regulator of colorectal carcinogenesis, whose deletion promoted cell proliferation and survival in human CRC cells, tumor growth upregulated amino-acid metabolism mice. However, what happens when silencing SNX10 normal intestinal epithelial cells (IECs) remains unknown, no drugs targeting have reported. Here, we first investigated the biological function underlying mechanisms IECs, found that α-hederin, pentacyclic...
Objective: To identify the chemical components of Shenbai Jiedu Decoction (SBJDD) and analyze potential mechanism SBJDD preventing treating colorectal adenoma (CRA) carcinogenesis. Method: The was separated by using ultra-high performance liquid chromatography-time flight-mass spectrometry (UPLC-Q-TOF-MS) technology, mass information combined with reference literatures were used to ingredient SBJDD. Non-targeted metabolomics screen differential endogenous metabolites in plasma SBJDD-treated...