A5039570310- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Rheumatoid Arthritis Research and Therapies
- Crystallography and molecular interactions
- Cytokine Signaling Pathways and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Bone Metabolism and Diseases
- Vasculitis and related conditions
- Cerebrovascular and Carotid Artery Diseases
- Galectins and Cancer Biology
- Lymphoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- IL-33, ST2, and ILC Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Structural Anomalies and Repair
Guizhou University
2008-2025
Affiliated Hospital of Guizhou Medical University
2021-2024
Nanjing University
2023-2024
Nanjing Drum Tower Hospital
2023-2024
Chongqing Medical University
2014-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Gannan Medical University
2021-2023
Guiyang Medical University
2018-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Guizhou Cancer Hospital
2022
As important effector cells in inflammation, macrophages can be functionally polarized into either inflammatory M1 or alternatively activated anti-inflammatory M2 phenotype depending on surroundings. The key roles of glycolysis macrophage polarization have been well defined. However, the relationship between and is still poorly understood. Here, we report that 2-deoxy-d-glucose (2-DG), an inhibitor glycolytic pathway, markedly inhibited expressions Arg, Ym-1, Fizz1, CD206 molecules,...
Cerebral small vessel disease (CSVD) is a clinically commonly-seen slow-progressing cerebral vascular disease. As classic Chinese formula for the treatment of stroke, Daqinjiao Decoction (DQJD) now used to treat CSVD with desirable effect. Since mechanism action still unclear, this article will explore therapeutic effect and using network pharmacology technology.The major chemical components potential target genes DQJD were screened by bioinformatics. The key targets in identified based on...
Imperatorin, an active ingredient extracted from Angelica and Qianghuo, has anti-inflammatory, anti-oxidative stress damage, blocking calcium channels, other properties. Our preliminary findings revealed the protective role of imperatorin in treatment vascular dementia, we further explored underlying mechanisms concerning neuroprotection function dementia. The cobalt chloride (COCl2)-induced chemical hypoxia hypoglycemia hippocampal neuronal cells was applied as vitro dementia model. Primary...
Abstract In view of the complicated pathophysiological process vascular dementia (VD), drugs for clinical treatment VD mainly target related risk factors, while with excellent efficacy in cognitive function are still relatively lacking. Imperatorin (IMP), an active constituent extracted from angelica dahuricae and notopterygium Notopterygii, which has anti-inflammatory, vasodilator, anticoagulant, block calcium channel, anticonvulsant, anti oxygen free radical injury properties....
Although the pathogenesis of rheumatoid arthritis (RA) remains unclear, an increasing number studies have confirmed that pyroptosis fibroblast-like synoviocytes (RA-FLS) is important factor affecting progression RA. Periplogenin (PPN) a natural cardiac glycoside; reportedly, it exerts anti-inflammatory and analgesic effects in diseases by inhibiting cell growth migration. This study aimed to determine effect PPN on growth, migration, invasion RA-FLS potential mechanism regulation. We...
Acute intracerebral hemorrhage (ICH) is prone to multiple organ dysfunction and has high disability mortality. This study was determine the role of acute physiology chronic health evaluation II (APACHE II) scoring system in prediction severity outcome ICH.A total 546 ICH patients were prospectively recruited between 1 January 2013 31 December 2014. Patients divided into three groups according APACHE scores: low score group (5-16), moderate (17-28) (≥29). The volume location, National...
Rheumatoid arthritis (RA) displays very similar characteristics to those of tumor cells, platycodin D (PD) is a triterpenoid saponin abundant in Platycodon grandiflorum (PG), plays an important role the inhibition growth. Our previous experiments confirmed that PD inhibited MH7A cell proliferation and migration, but it's possible mechanism remain unclear. This study aimed reveal on RA, based network pharmacology analysis. Rat CIA was treated with different doses PD. The score paw volume were...
Guest–host inclusion complexes between 6-benzyladenine (6-BA), cucurbit[7]uril (Q[7]), symmetrical tetramethylcucurbit[6]uril (TMeQ[6]) and meta-hexamethyl-substituted cucurbit[6]uril (HMeQ[6]) in aqueous solution were investigated by 1H NMR, UV absorption spectroscopy phase solubility studies. The NMR spectra analysis revealed that the hosts selectively bound phenyl moiety of guests. Absorption spectroscopic defined stability host–guest complexes. A host:guest ratio 1:1 was measured...
Objective This study aimed to investigate the role of muscle pain in post-stroke syndromes. Design cross-sectional–designed enrolled 145 stroke patients at three different duration periods (≤3 mos, 3 mos 1 yr, and >1 yr) receiving inpatient or outpatient rehabilitation programs a regional teaching hospital. Three common tender points (two upper trapezius one brachioradialis) two relative periosteum healthy hemiparetic sides were identified for evaluation. Spontaneous intensity measured with...
Rheumatoid arthritis (RA) represents the consequence of an immune response body's system attacking healthy cells. This chronic inflammatory disorder has complicated pathogenesis. Traditional Chinese medicine (TCM) is well recognized as effective therapy in treating RA and been widely applied for centuries. Wu-Teng-Gao (WTG) used a representative natural herb formula treatment China, while its mechanisms are to be fully clarified. The present study attempted explore WTG on network...
Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease characterized with high recurrence, disability, poor prognosis, and long treatment cycles. Versus western medicine, traditional Chinese medicine has the traits of definite efficacy, low toxicity, side effects in RA. Moreover, also advantages multiple targets, links, approaches. This study was committed to exploring effect Jinwujiangu prescription on peripheral blood osteoclasts those patients RA relevant molecular...
BACKGROUND:Worldwide, stroke results in healthcare costs and economic costs, particularly patients aged <45 years. This study aimed to evaluate the factors influencing burden of ischemic younger China based on Trial Org 10172 Acute Stroke Treatment (TOAST) etiological classification. MATERIAL AND METHODS:Retrospective review medical records 961 between 18–45 years, diagnosed with acute stroke, was performed identify for one year. severity assessed using modified Rankin Scale (mRS) score...
Fluorescent indicator displacement assays have become popular for converting synthetic receptors into optical sensors. We now shown that a 1:2 host–guest complex between cucurbit[8]uril (Q[8]) and proflavine (PF) can be used as fluorescent sensing the anticancer drug gefitinib. The 2PF@Q[8] to detect gefitinib with high selectivity using fluorescence spectrometry detection limit of 6.63 × 10−8 mol−L. proposed mechanism was investigated 1H nuclear magnetic resonance spectroscopy (1H NMR),...
The Src homology 2 domain-containing tyrosine phosphatase (SHP2) is a non-receptor and acts as convergent node for oncogenic cell-signaling cascades. SHP2 has been recognized breakthrough anti-tumor therapeutic target. However, it still elusive the role of in manipulating tumor microenvironment malignancy. Here, we found that activation tumor-associated macrophages (TAMs) paralleled mammary carcinoma progression. Co-culture system human breast cancer specimens also showed high levels...
Infiltration and aggregation of lymphocytes in exocrine glands are the basic pathological manifestations Sjögren's syndrome (SS), incidence SS has been increasing year by recent years. To explore potential signaling pathway Runzaoling (RZL) alleviating SS, possible targets RZL were firstly explored through network pharmacology, then, regulation PI3K/AKT/mTOR NOD mice Th17 cells was verified. 75 8-week-old casually classified into 5 groups: model; hydroxychloroquine; high, medium, low dose...
C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is a risk factor for stroke, suggesting that widespread detection could help to prevent stroke. DNA from 70 stroke patients and healthy controls was extracted saliva using magnetic nanoparticles-based method blood conventional methods. Real-time PCR results revealed genotyped by both samples. The genotype were confirmed sequencing, samples consistent. mutation TT frequency significantly higher group than controls....