A5100602642- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- RNA modifications and cancer
- Diabetes Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cancer-related molecular mechanisms research
- Cardiac Imaging and Diagnostics
- RNA Research and Splicing
- Insect and Pesticide Research
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Physiological and biochemical adaptations
- Lung Cancer Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Plant and animal studies
- Immune Response and Inflammation
- Epilepsy research and treatment
- Cardiac electrophysiology and arrhythmias
- Aortic Disease and Treatment Approaches
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Insect Pheromone Research and Control
- Epigenetics and DNA Methylation
Massachusetts General Hospital
1992-2025
Harvard University
1996-2025
Zhejiang University
2022-2025
Ministry of Agriculture and Rural Affairs
2022-2025
Hangzhou Dianzi University
2020-2025
Nanjing Normal University
2023-2025
Harbin Medical University
2019-2024
Third Affiliated Hospital of Harbin Medical University
2019-2024
Shenyang Agricultural University
2023-2024
Canadian VIGOUR Centre
2024
Combination of chemotherapy and immune checkpoint inhibitor therapy has greatly improved the anticancer effect on multiple malignancies. However, efficiency triple-negative breast cancer (TNBC) is limited, since most patients bear "cold" tumors with low tumor immunogenicity. Doxorubicin (DOX), one effective agents, can induce immunogenic cell death (ICD) thus initiating response.In this study, to maximize ICD induced by DOX, chitosan cell-penetrating peptide (R6F3)-modified nanoparticles...
The codling moth Cydia pomonella (Lepidoptera: Tortricidae) is a major invasive pest of pome fruits and walnuts worldwide. Lambda-cyhalothrin (LCT) abamectin (AM) have been frequently used in C. control, but control this very difficult because shortly after hatching, larvae insect bore tunnels hide inside host plant fruit. In study, simulated field spray bioassay method was developed against neonate concentration-response bioassays were conducted to evaluate the susceptibility LCT AM....
Abstract Background Diabetic cardiomyopathy (DbCM) is a form of Stage B heart failure (HF) at high risk for progression to overt disease. Using baseline characteristics study participants from the Aldose Reductase Inhibition Stabilization Exercise Capacity in Heart Failure (ARISE-HF) Trial we sought characterize clinical individuals with findings consistent DbCM. Methods Among meeting inclusion criteria, characteristics, laboratory testing, imaging, Kansas City Cardiomyopathy Questionnaire...
Abstract Malignant melanoma is aggressive and has a high mortality rate. Toll-like receptor 4 (TLR4) been linked to growth, angiogenesis metastasis. However, signal transduction mediated by TLR4 for driving progression not fully understood. Signal transducer activator of transcription 3 (STAT3) identified as major oncogene in progression. We found: that expression positively correlates with activation/phosphorylation STAT3 human samples; ligands activate through MYD88 TRIF cells;...
Abstract Background Although mesenchymal stem cells (MSCs) have been effective in tendinopathy, the mechanisms by which MSCs promote tendon healing not fully elucidated. In this study, we tested hypothesis that transfer mitochondria to injured tenocytes vitro and vivo protect against Achilles tendinopathy (AT). Methods Bone marrow H 2 O -injured were co-cultured, mitochondrial was visualized MitoTracker dye staining. Mitochondrial function, including membrane potential, oxygen consumption...
Development of alternative linear peptides for targeting αvβ3 integrin has attracted much attention, as the traditional peptide ligand, cyclic RGD, is limited by inferior water-solubility and complex synthesis.Using pharmacophore-based virtual screening high-throughput molecular docking, we identified two novel small RWr RWrNM with high affinity specificity to integrin.The competitive binding RGD (c(RGDyK)) cellular uptake related expression levels verified their intermolecular interaction...
Doses of sacubitril/valsartan (Sac/Val) achieved in clinical trials heart failure with reduced ejection fraction (HFrEF) are often not reached practice.The purpose this study was to investigate associations among Sac/Val doses and changes prognostic biomarkers, health status, cardiac remodeling individuals HFrEF through 12 months treatment administered per usual care.A total 794 persons (ejection [EF] ≤40%) were categorized according average daily divided into tertiles. Change from baseline...
Abstract Overactive fatty acid metabolism is usually found in hematological malignancies including multiple myeloma (MM), but the underlying mechanisms remain unclear. Here, we reveal that acyl-CoA synthetase long-chain family member 4 (ACSL4) abnormally overexpressed MM cell lines and patients compared to healthy donors. Knockdown of ACSL4 inhibited proliferation reduced levels possibly by regulating lipid genes c-Myc sterol regulatory element binding proteins (SREBPs). As a propellent...
Haemophilus parasuis (H. parasuis) is the etiological agent of Glässer's disease in pigs. Currently, molecular basis this infection largely unknown. The innate immune response first line defense against infectious disease. Systematical analysis on host to important for understanding pathogenesis microorganisms.A total 428 differentially expressed (DE) genes were identified porcine alveolar macrophages (PAMs) 6 days after H. infection. These principally related inflammatory response,...
Background Higher lipoprotein(a) and oxidized phospholipid concentrations are associated with increased risk for coronary artery disease valvular heart disease. The role of or as a factor incident failure (HF) its complications remains uncertain. Methods Results A total 1251 individuals referred angiography in the Catheter Sampled Blood Archive Cardiovascular Diseases (CASABLANCA) study were stratified on basis universal definition HF stage; those stage A/B (N=714) followed up an average 3.7...
BACKGROUND: Objective indices of functional capacity in patients with diabetic cardiomyopathy and stage B heart failure (HF) have not been comprehensively defined. We sought to characterize the cardiopulmonary exercise characteristics individuals at high risk for overt HF. METHODS: The relationships from testing clinical laboratory participants were evaluated using baseline data ARISE-HF trial (Aldose Reductase Inhibition Stabilization Exercise Capacity Heart Failure). Cluster phenogroups...