A5101795875- Natural product bioactivities and synthesis
- Medicinal Plant Pharmacodynamics Research
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Advanced Sensor and Energy Harvesting Materials
- Essential Oils and Antimicrobial Activity
- Medicinal Plants and Neuroprotection
- Fungal Biology and Applications
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Flavonoids in Medical Research
- Traditional Chinese Medicine Studies
- Medicinal Plant Research
- Catalytic C–H Functionalization Methods
- Conducting polymers and applications
- Neurological Disease Mechanisms and Treatments
- Advanced Glycation End Products research
- Hydrogels: synthesis, properties, applications
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Phytochemistry and biological activity of medicinal plants
- GABA and Rice Research
- Tea Polyphenols and Effects
Jiangsu Provincial Academy of Traditional Chinese Medicine
2012-2024
Nanjing University of Chinese Medicine
2016-2024
University of Science and Technology of China
2023-2024
Yancheng Institute of Technology
2023-2024
South China University of Technology
2022-2023
Gannan Medical University
2022
University of Louisville
2019
Changzhou University
2017
Jiangsu University
2011
Macau University of Science and Technology
2010
The main purpose of this study was to evaluate the intestinal absorption and antineoplastic effect poorly water-soluble drug celastrol when liposomes were used as oral delivery system. Liposomes prepared by ethanol-injection method. An optimized liposome formulation composed phospholipid, cholesterol Tween-80 resulted in favorable encapsulation efficiency at 98.06 ± 0.94%. Homogeneous stable particle size 89.6 7.3 nm zeta potential −(87.7 5.8) mV determined laser analyzer. Subsequently,...
Purpose: Yinyanghuo (Herba Epimdii) is a traditional Chinese herb containing prenylated flavonoids as its active constituents. The aim of this study was to examine the significance intestinal hydrolysis by lactase phlorizin hydrolase (LPH), an enzyme at brush border membrane cells. Methods: A four-site perfused rat model used. concentration interest and their metabolites in different segements were analyzed HPLC, apparent permeabilities calculated. inhibitor (gluconolactone) employed...
The aim of this study was to establish a paclitaxel (PTX)-loaded mixed micelle delivery system (PTX-TP-M) with vitamin E-TPGS (TPGS) and Plasdone®S-630 Copovidone (PVPS630) as carriers improve the solubility, oral absorption, anti-tumor activity PTX against lung cancer. In study, PTX-TP-M prepared using ethanol thin-film dispersion method followed by characterization binary micelles system. average size 83.5 ± 1.8 nm polydispersity index 0.265 0.007 drug loading (DL%) entrapment efficiency...
Ginseng, the root of Panax ginseng (PG), is used widely as a herbal medicine to prevent and treat various diseases. has pharmacological effects on neurodegenerative diseases such Alzheimer's disease (AD). The present study evaluated neuroprotective PG its possible mechanisms in advanced glycation end product (AGE)-induced AD rat model.Advanced products were injected bilaterally into CA3 region rats' brains. Morris water maze test step-down type passive avoidance performed evaluate their...
Phyllanthus emblica L (PEL), a well-known medical plant, has been used in Asian countries for long time. Increasing evidence suggests that it can prevent the tumorigenesis of cancer associated with nonresolving inflammation. However, possible anti-inflammatory mechanism responsible preventing precancerous lung lesions is not well elucidated.Male A/J mice were randomly divided into 5 groups 10 each group: (1) blank group (saline), (2) benzo(a)pyrene [B(a)P] group, (3) and (4) B(a)P + PEL (5...
Regulation of myeloid-derived suppressor cells (MDSC) by ongoing inflammation following repeated chemotherapy remain elusive. In this study, we show that a multidose clinical regimen gemcitabine (GEM) treatment enhances the immunosuppressive function monocytic MDSC (M-MDSC), although tumor development is delayed in E0771 tumor-bearing mice. Accordingly, effector IFN-γ-producing CD4 and CD8 T are significantly decreased microenvironment (TME) GEM-treated The conditioned medium differentiation...
Cigarette smoking is the main cause of chronic obstructive pulmonary disease and lung cancer. The present study was aimed to explore chemopreventive effect ursolic acid (UA) on these diseases. In CSE treated normal human bronchial epithelial cell model, UA alleviated cytotoxicity caused by CSE, recovered intracellular redox balance, relieved stimulation external deleterious factors as well. mitigated CSE-induced DNA damage through Nrf2 (nuclear factor erythroid 2-related 2) pathway....
Baohuoside I is an effective anti-cancer drug currently used for a variety of cancers in vitro. Unfortunately, baohuoside has very poor solubility both water and organic solvents. Besides that, it subject to significant efflux. This work therefore aimed at evaluating the ability mixed micelles solubilize I, increase permeability inhibit efflux promote oral absorption. A novel (TPGS–baohuoside I–phospholipid complex) was formed by phospholipid complex TPGS solubility, enhance permeability, I....
The Chaihu-Shaoyao drug pair (Bupleuri Radix and Paeoniae Alba) which is a traditional Chinese pair, has been widely used for anti-inflammatory purposes. Saikosaponin (SSA), saikosaponin d (SSD) paeoniflorin are identified as the main components in pair. present study focused on interaction of based investigating their intestinal absorption using four-site perfused rat model order to clarify mechanism compatibility Chaihu-Shaoyao. concentrations SSA, SSD perfusate were determined by LC/MS or...
Lung cancer is a common malignant tumor in clinical practice, and its morbidity mortality are the forefront of tumors. Radiotherapy, chemotherapy, surgical treatment play an important role lung cancer, however, radiotherapy has many complications even causes partial loss function, recurrence rate after resection high, toxic side effects chemotherapy drugs strong. Traditional Chinese medicine played huge prognosis improvement among them, Zengshengping (ZSP) effect preventing treating cancer....
The efficacy of Prunella extracts in the prevention and treatment lung cancer has been attributed to different components. In this study, an "active components combination model" hypothesis was proposed explain anti-tumor activity Prunella. from regions compared vitro vivo, TNF-α serum tumor-bearing mice also evaluated. High performance liquid chromatography (HPLC) used analyze identify 26 common peaks. samples were classified by cluster analysis method; both P. vulgaris L. Bozhou asiatica...
In this work, the metabolite profiles of epimedin B in rat feces, bile, urine, and plasma were qualitatively investigated, possible metabolic pathways subsequently proposed. After oral administration at a single dose 80 mg/kg, biological samples collected pretreated by protein precipitation. Then, these injected into an Acquity ultraperformance liquid chromatography BEH C₁₈ column with mobile phase consisting 0.1% formic acid-water acid-acetonitrile detected...