A5100367370- Bone Metabolism and Diseases
- Bone health and treatments
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
- Semantic Web and Ontologies
- Ectopic Pregnancy Diagnosis and Management
- Transportation and Mobility Innovations
- Phosphodiesterase function and regulation
- Peroxisome Proliferator-Activated Receptors
- Advanced Image Fusion Techniques
- S100 Proteins and Annexins
- Potato Plant Research
- Advanced Glycation End Products research
- Phytochemical Studies and Bioactivities
- Endoplasmic Reticulum Stress and Disease
- Distributed Sensor Networks and Detection Algorithms
- Digital Media Forensic Detection
- Advanced Image Processing Techniques
- Smart Parking Systems Research
- Cognitive Radio Networks and Spectrum Sensing
- ATP Synthase and ATPases Research
- Phytochemistry and Biological Activities
- Advanced Data Compression Techniques
- Plant and animal studies
Guangzhou University of Chinese Medicine
2019-2024
The University of Western Australia
2016-2024
Shenzhen Institutes of Advanced Technology
2024
Shenzhen University
2024
Chinese Academy of Sciences
2024
PLA Academy of Military Science
2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2019-2022
Gansu University of Traditional Chinese Medicine
2021
Zhengzhou University
2020
Southern Medical University
2011-2017
Rationale: Osteoporosis is a severe bone disorder that threat to our aging population. Excessive osteoclast formation and resorption lead changes in trabecular volume architecture, leaving the bones vulnerable fracture. Therapeutic approaches of inhibiting osteoclastogenesis have been proven be an efficient approach prevent osteoporosis. In study, we demonstrated for first time Loureirin B (LrB) inhibits ovariectomized osteoporosis explored its underlying mechanisms action vitro. Methods: We...
Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common bone and joint disease. There currently lack effective treatment for GIONFH, disease progression may lead to total hip arthroplasty (THA). The exact mechanism GIONFH pathogenesis remains unsettled, emerging evidence indicates that overactivation osteoclasts plays pivotal role in occurrence this condition. Our previous study has shown cycloastragenol (CAG), triterpenoid saponin with multiple bioactivities, natural...
Osteoporosis, which typically affects postmenopausal women, is an osteolytic disease due to over-activation of osteoclasts. However, current drugs targeting osteoclast inhibition face various side effects, making natural compounds with great interest as alternative treatment options. Cycloastragenol (CAG) a triterpenoid multiple biological activities. Previously, CAG's activity against aging-related osteoporosis was reported, but the mechanisms actions for activities were not understood....
The present study aimed to examine the effects of isopsoralen against postmenopausal osteoporosis in an ovariectomized rat model. rats were treated with three days 10 mg/kg or 20 isopsoralen. Alkaline phosphatase, oxidative stress indicators and caspase‑3/9 measured using ELISA assay kits. Reverse transcription‑quantitative polymerase chain reaction was used measure collagen type I (Col I), osteocalcin osteoprotegerin mRNA levels. Wnt, β‑catenin peroxisome proliferators‑activated receptor γ...
Excessive activity of osteoclasts contributes to skeletal diseases such as osteoporosis and osteolysis. However, current drugs targeting osteoclast have various deficiencies, placing natural compounds substitutions great potential. Roburic acid (RA) is a triterpenoid exacted from Radix Gentianae Macrophyllae, which exhibits inhibitory effects on inflammation oxidation. By employing an in vitro osteoclastogenesis model, this study investigates the mechanisms RA intracellular signaling induced...
The video quality can be degraded because of physical problems such as repeated projection, low-quality compression/decompression, or bad chemical decomposition the original recording material. It becomes increasingly important to locate (video with defects) wide application digital media. One common defection is mosaic, where several even square combined together and image information lost. In this paper, after analyzing characteristic mosaic defect in detail, a detection approach spatial...
Bone formation, which is inhibited by particulate wear debris, a pathological factor that contributes to periprosthetic osteolysis. Although the nuclear of activated T cells c1 (NFATc1) known be involved in osteoblast differentiation, and its effect on osteoblasts response particles remains unclear. In this study, we investigated role NFATc1 regulation osteoblastic differentiation rat calvaria (RC) (a cell-culture model comprising many osteoprogenitors) were challenged with titanium (Ti)...
Intravitreal delivery can maximize the intensity of therapeutic agents and extend their residence time within ocular tissue. Melatonin is a lipophilic molecule that crosses freely biological barriers cell membranes. This study intends to investigate effects intravitreally delivered melatonin on mouse retina. The visual function administered mice assessed by electrophysiological behavior examinations three weeks after intravitreal delivery. Moreover, multi-electrode array (MEA) was used...
This work deals with the issue of blind cooperative spectrum sensing using distributed sensors large-scale fading. We first investigate Friedman-test-based nonparametric detector and analyze its performance. Due to operations instantaneous power passing ranking, has relatively high-sensing overhead computational complexity. To overcome these drawbacks, we then propose a parametric for which only local average is needed ranking avoided. Compared detector, delivers better performance much...
Compression artifacts are the results of an aggressive data compression scheme applied to image that discards some which is determined by algorithm be lesser importance overall contents but nonetheless discernible and objectionable user. In this paper we present a post-processing focuses on restoring clarity important features removing ringing around edges at ratios 100:1 greater. At decoder, extracts locations from reconstructed classifies pixels surrounding for artifacts.
The proliferation of Large Language Models (LLMs) has led to an influx AI-generated content (AIGC) on the internet, transforming corpus Information Retrieval (IR) systems from solely human-written a coexistence with LLM-generated content. impact this surge in AIGC IR remains open question, primary challenge being lack dedicated benchmark for researchers. In paper, we introduce Cocktail, comprehensive tailored evaluating models mixed-sourced data landscape LLM era. Cocktail consists 16...
Abstract Bone is a dynamic organ which continuously undergoes remodeling throughout one's lifetime. Cellular production of reactive oxygen species (ROS) essential for regulating bone homeostasis. Osteoclasts, multinucleated giant cells differentiated from macrophage lineage, are responsible osteolytic conditions closely linked to ROS signaling pathways. In this study, an anti‐ROS enzyme, peroxiredoxin 1 (Prdx1) was found be expressed both in marrow macrophages and osteoclasts. Recombinant...
Objective To explore the effect of calcitonin gene-related peptide (CGRP) on proliferation and differentiation MG-63 cells through extracellular signal-regulated kinase (ERK) pathway in vitro. Methods study effects ERK inhibitor PD98059 CGRP CGRP8-37, 2 groups were treated with CGRP8-37 for one hour prior to serum treatment. The other 4 cultured different doses (high, middle, low blank). Proliferation apoptosis observed by methyl thiazolyl tetrazolium (MTT) method cell-counting.Expressions...
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