A5101788577- Bone Metabolism and Diseases
- NF-κB Signaling Pathways
- Bone health and treatments
- Pharmacological Effects of Medicinal Plants
- Trace Elements in Health
- Orthopaedic implants and arthroplasty
- Animal Virus Infections Studies
- Gastric Cancer Management and Outcomes
- Inflammatory mediators and NSAID effects
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Oral microbiology and periodontitis research
- Phytochemical Studies and Bioactivities
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Natural Compounds in Disease Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Liver Disease and Transplantation
- Cancer Research and Treatments
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- ATP Synthase and ATPases Research
- Natural product bioactivities and synthesis
Guangxi Medical University
2013-2024
First Affiliated Hospital of GuangXi Medical University
2013-2023
The University of Western Australia
2011-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Yunnan Agricultural University
2015
China Pharmaceutical University
2013
Chongqing Medical University
2009
Harvard University
2009
Children's Hospital of Chongqing Medical University
2009
Boston Children's Hospital
2009
Osteolytic bone diseases including osteoporosis are commonly accompanied with enhanced osteoclast formation and resorption. Naringin, a natural occurring flavonoid has been found to protect against retinoic acid-induced improve quality in rats. Here, we showed that naringin perturbs resorption by inhibiting RANK-mediated NF-κB ERK signaling. Naringin suppressed gene expression of key marker genes. was inhibit RANKL-induced activation suppressing RANKL-mediated IκB-α degradation. In addition,...
Abstract The key target for treating inflammatory osteolysis is osteoclasts. In an environment, osteoclast differentiation increases, and bone resorption enhanced. Periplogenin (Ppg) a traditional Chinese medicine. It has anti-inflammatory antitumor effects, but its impact on unknown. This study found that Ppg prevented LPS-induced skull by inhibiting the expression of cytokines production. vitro, blocked RANKL-induced generation osteoclasts, development pseudopodia bands, resorption. also...
Small ubiquitin-like modifier 1 (SUMO-1) modification of IkappaBalpha has been described to actively participate in NFkappaB regulation. Following proteosomal degradation IkappaBalpha, an auto-regulatory loop consisting transcriptional activation gene and SUMO-1 newly synthesized proceeds. The SUMOylated form is resistant signal-induced degradation, consequently halting activation. We describe a mechanistic model by which adenosine (Ado) signaling results significant accumulation modified...
Wearing titanium particle-induced osteoclastogenesis, accompanied by peri-implant osteolysis, is the main cause of long-term failure hip prosthesis. Currently, medications used for prevention and treatment osteolysis show serious side effects. Therefore, development more effective new drugs with less effects extremely urgent. Vaccarin a natural flavonoid extracted from Vaccaria segetalis, various biological functions, including antioxidantory, anti-inflammatory, promotion angiogenesis....
Abstract Periodontal disease and arthroplasty prosthesis loosening destabilization are both associated with osteolysis, which is predominantly caused by abnormal bone resorption triggered pro‐inflammatory cytokines. Osteoclasts (OCs) critical players in the process. Concerns regarding long‐term efficacy side effects of current frontline therapies, however, remain. Alternative therapies still required. The aim this work was to investigate involvement Tenacissoside H (TDH) RANKL‐mediated OC...
Osteoporosis is a disease characterized by abnormally increased formation and function of osteoclasts.Anti-RANKL treatment using natural medicine potential therapy for osteoporosis.Here, we studied the effect fangchinoline, which extracted from root Stephania tetrandra S. Moore, on osteoclast function.We found that fangchinoline inhibited osteoclastogenesis at doses 0.5 1 µM.In addition, also examined mechanism inhibitory osteoclasts.We down regulated NFATc1 activity expression.However, did...
Porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of an economically important swine disease that has devastated industry since late 1980s. The aim present study was to investigate interaction between reactive oxygen species (ROS) NF-κB by PRRSV infection. We isolated local strain from southwest China, designated YN-2011, then sequenced analyzed genome. YN-2011 used evaluate ROS NF-κB. In infected MARC-145 cells, there a time-dependent increase in Maleic Dialdehyde...
Abstract The increased activation of osteoclasts is the major manifestation several lytic bone diseases, including osteoporosis, rheumatoid arthritis, aseptic loosening orthopedic implants, Paget disease and malignant diseases. One important bone‐protective therapy in these diseases focuses on inhibition osteoclast differentiation resorptive function. Given that deleterious side‐effects currently available drugs, it beneficial to search for effective safe medications from natural compounds....
Osteoporosis is a prevalent systemic metabolic disease in modern society, which patients often suffer from bone loss due to over-activation of osteoclasts. Currently, amelioration through modulation osteoclast activity major therapeutic strategy. Ataxia telangiectasia mutated (ATM) inhibitor CGK733 (CG) was reported have sensitizing impact treating malignancies. However, its effect on osteoporosis remains unclear. In this study, we investigated the effects CG differentiation and function, as...
Hepatitis B X-interacting protein (HBXIP, also termed as LAMTOR5) plays a crucial role in regulation of cancer progression, while the mechanism is still unclear. Here we found that HBXIP increased expression PPARδ (peroxisome proliferator-activated receptor-δ) gene and levels SW480 or HT-29 colonic cells. Chromatin immunoprecipitation luciferase reporter assays showed occupied core promoter (-1079/-239 nt) regions activated transcription activity an NF-κB (p65)-dependent manner. Moreover,...
Abstract Bone is a dynamic organ which continuously undergoes remodeling throughout one's lifetime. Cellular production of reactive oxygen species (ROS) essential for regulating bone homeostasis. Osteoclasts, multinucleated giant cells differentiated from macrophage lineage, are responsible osteolytic conditions closely linked to ROS signaling pathways. In this study, an anti‐ROS enzyme, peroxiredoxin 1 (Prdx1) was found be expressed both in marrow macrophages and osteoclasts. Recombinant...
Abstract The key target for treating inflammatory osteolysis is osteoclasts. In an environment, osteoclast differentiation increases, and bone resorption enhanced. Periplogenin (Ppg) a traditional Chinese medicine. It has anti-inflammatory antitumor effects, but its impact on unknown. This study found that Ppg prevented LPS-induced skull by inhibiting the expression of cytokines production. vitro, blocked RANKL-induced generation osteoclasts, development pseudopodia bands, resorption. also...
Objective To study the application value of preoperative serum CEA, CA19-9 and CA50 in prediction liver metastasis colorectal cancer. Methods A total 316 patients with cancer who underwent surgery at Cancer Hospital Chinese Academy Medical Sciences from January 2015 to 2017 were enrolled this study. Among them, 158 metastases included observation group. Other case-matched without control Preoperative carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9), 50 (CA50) measured all...