A5100717688- Immune Response and Inflammation
- Animal Virus Infections Studies
- Escherichia coli research studies
- Extracellular vesicles in disease
- Vibrio bacteria research studies
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- Inflammasome and immune disorders
- Antibiotic Resistance in Bacteria
- CRISPR and Genetic Engineering
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Environmental and Agricultural Sciences
- Autophagy in Disease and Therapy
- Congenital gastrointestinal and neural anomalies
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Medical Research and Treatments
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Methane Hydrates and Related Phenomena
- Amoebic Infections and Treatments
- Gout, Hyperuricemia, Uric Acid
- Inflammation biomarkers and pathways
- Sulfur Compounds in Biology
Yunnan Agricultural University
2007-2025
Sun Yat-sen University
2023-2024
Inner Mongolia University of Technology
2024
Nanjing Tech University
2024
Tulane University
2024
East China Normal University
2024
City University College of Science and Technology
2023
Anhui University of Technology
2022
University of Chinese Academy of Sciences
2022
Rice Research Institute
2021
Abstract The application of straw and biochar can effectively improve soil quality, but whether such impacts paddy bacterial community development remains to be clarified. Herein, the three different field amendment strategies were assessed including control (CK) treatment, rice (RS) (9000 kg ha −1 ), (BC) (3150 ). Soil samples collected at five stages growth, communities therein characterized via high-throughput 16S rDNA sequencing. results these analyses revealed that dominated by...
Abstract Immune checkpoint blockade (ICB) therapy has achieved remarkable therapeutic effects in cancer, but it is not effective glioblastoma (GBM). The main reason that difficult for drugs to penetrate blood‐brain‐barrier (BBB) GBM and lacks enough pre‐existing cytotoxic CD8 + T cells microenvironment. Here, two AIE photothermal agents (Fs Fo) are synthesized with NIR‐II fluorescence emission increase molecular twisting of by simply changing one O atom into S atom, improving Fs conversion...
Kidney stones or nephrolithiasis is a chronic metabolic disease characterized by renal colic and hematuria. Currently, pathogenetic mechanism resulting in kidney stone formation remains elusive. We performed multi-omic study investigating urinary microbial compositions alterations during nephrolithiasis.Urine samples from healthy individuals with were collected for 16S rRNA gene sequencing liquid chromatography-mass spectroscopy. Microbiome metabolome profiles analyzed individually combined...
The high-pathogenicity island (HPI) was initially identified in Yersinia and can be horizontally transferred to Escherichia coli produce yersiniabactin (Ybt), which enhances the pathogenicity of E. by competing with host for Fe3+. Pyroptosis is gasdermin-induced necrotic cell death. It involves permeabilization membrane accompanied an inflammatory response. still unclear whether Ybt HPI cause intestinal epithelial cells undergo pyroptosis contribute gut inflammation during infection. In this...
Methanol steam reforming hydrogen production provides a solution for the portable development of hydrogen–oxygen fuel cells with working mode "on-site and ready-to-use". In this paper, catalytic combustion chamber is redesigned, autothermal nozzle microchannel reactor (ANMR) system proposed efficient methanol produced. The performance superiority ANMR demonstrated by comparison traditional reactors, optimization scheme structure studied. results show that improves overall improving...
Escherichia coli ( E. ), a major foodborne pathogen, poses significant risks to public health by causing gastrointestinal diseases. Among its virulence factors, Yersiniabactin (Ybt), siderophore, plays crucial role in iron acquisition and enhancing intestinal colonization. Despite previous studies highlighting -Ybt’s involvement inflammation, exact mechanisms remain unclear. This study investigates how Ybt contributes inflammation through ferroptosis, using both vitro vivo models. Our...
CRISPR/Cas9, as a well-established gene editing technology, has been applied in numerous model organisms, but its application wild-type E. coli remains limited. Pathogenic coli, major cause of foodborne illnesses and intestinal inflammation humans animals, poses significant global public health threat. The valine-glycine repeat protein G (VgrG) is key virulence factor that enhances pathogenicity. In this study, PCR was used to identify 50 strains carrying the VgrG2 out 83 wild pathogenic...
Hemolysin-coregulated protein 1 (Hcp1) is an effector released by the type VI secretion system (T6SS) in certain pathogenic strains of Escherichia coli (E. coli) that causes apoptosis and contributes to development meningitis. The exact toxic consequences Hcp1 whether it intensifies inflammatory response triggering pyroptosis are yet unknown. Here, utilizing CRISPR/Cas9 genome editing method, we removed gene expressing from wild-type E. W24 examined impact on virulence Kunming (KM) mice. It...
Abstract Background Pyroptosis plays a pivotal role in the pathogenesis of many inflammatory diseases. The molecular mechanism by which pyroptosis is induced macrophages following infection with pathogenic E. coli high pathogenicity island (HPI) will be evaluated our study. Results After HPI + /HPI − strains and LPS, decreased macrophage cell membrane permeability integrity were demonstrated propidium iodide (PI) staining lactate dehydrogenase (LDH) assay. -infection was accompanied...
In this study, the anti-inflammatory and antiapoptotic effects of hydroxytyrosol (HT) in Mycoplasma gallisepticum (MG)-infected chicken were investigated, underlying molecular mechanisms explored. The results revealed severe ultrastructural pathological changes after MG infection lung tissue chicken, including inflammatory cell infiltration, thickening chamber wall, visible swelling, mitochondrial cristae rupture, ribosome shedding. possibly activated nuclear factor κB...
Porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of an economically important swine disease that has devastated industry since late 1980s. The aim present study was to investigate interaction between reactive oxygen species (ROS) NF-κB by PRRSV infection. We isolated local strain from southwest China, designated YN-2011, then sequenced analyzed genome. YN-2011 used evaluate ROS NF-κB. In infected MARC-145 cells, there a time-dependent increase in Maleic Dialdehyde...
To construct wild-type E. coli irp2 gene deletion strains, CRISPR/Cas9 editing technology was used, and the difficulty key points of strains were analyzed. Based on resistance system expression vector, 4 41 isolated from Saba pigs selected as target for gene, which sensitive to both ampicillin kanamycin. Then, combined with homologous recombination recombinant vectors containing Cas9, sgRNA donor sequences knock out gene. Finally, absence in further verified by iron uptake assays, carrier...
Strengthening ideological and political work is an important task for higher education institutions in various regions to implement the Party's educational guidelines, promote development enhancement of connotation work, fulfill fundamental moral talent cultivation.In current Internet era, across country have developed a good understanding importance work.However, there are also practical problems that hinder further advancement work.This paper aims analyze status institutions, combination...