A5049666235- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Geological and Geophysical Studies
- Cancer Immunotherapy and Biomarkers
- Luminescence and Fluorescent Materials
- Advanced Nanomaterials in Catalysis
- Hydrocarbon exploration and reservoir analysis
- Extracellular vesicles in disease
- Sulfur Compounds in Biology
- Seismic Imaging and Inversion Techniques
- Photoacoustic and Ultrasonic Imaging
- Geological and Geochemical Analysis
- RNA Interference and Gene Delivery
- Immune cells in cancer
- earthquake and tectonic studies
- Cancer, Hypoxia, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Enzyme Production and Characterization
- Nanoparticle-Based Drug Delivery
- Micro and Nano Robotics
- Biofuel production and bioconversion
- Nicotinic Acetylcholine Receptors Study
- Infant Nutrition and Health
- Selenium in Biological Systems
Sun Yat-sen University
2022-2025
Shenzhen Institutes of Advanced Technology
2017-2024
Chinese Academy of Sciences
2014-2024
Hong Kong University of Science and Technology
2020-2021
University of Hong Kong
2020-2021
University of Chinese Academy of Sciences
2017-2020
Guangdong Medical College
2020
University of Science and Technology of China
2020
Lifetech Scientific (China)
2020
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2020
Developing effective immunotherapies with low toxicity and high tumor specificity is the ultimate goal in battle against cancer. Here, we reported a cell-membrane immunotherapy strategy that was able to eliminate primary tumors inhibited distant by using natural killer (NK) cell membrane cloaked photosensitizer 4,4',4'',4'''-(porphine-5,10,15,20-tetrayl) tetrakis (benzoic acid) (TCPP)-loaded nanoparticles (NK-NPs). The proteomic profiling of NK membranes performed through shotgun proteomics,...
Nature has always inspired robotic designs and concepts. It is conceivable that biomimic nanorobots will soon play a prominent role in medicine. The "Terminator" the science fiction film cybernetic organism with living tissue over metal endoskeleton, which us to develop natural-killer-cell-mimic aggregation-induced emission (AIE) characteristics (NK@AIEdots) by coating natural kill cell membrane on an AIE-active polymeric PBPTV, highly bright NIR-II conjugated polymer. Owing AIE soft-matter...
Hypoxia is a common characteristic of solid tumors. This important feature associated with resistance to radio-chemotherapy, which results in poor prognosis and probability tumor recurrence. Taking advantage background-free NIR II fluorescence imaging deeper-penetrating photoacoustic (PA) imaging, we developed hypoxia-triggered nitroreductase (NTR) enzyme-responsive single molecule probe for high-contrast II/PA hypoxia-activated photothermal therapy (PTT), will overcome cellular during...
Abstract Photodynamic therapy (PDT) is a promising alternative approach for effective cancer treatment that associated with an antitumor immune response. However, immunosuppression of the tumor microenvironment limits response induced by PDT. Stimulation and proliferation T cells critical step generating responses depends on efficient presentation antigens co‐stimulatory molecules antigen‐presenting (APCs). Here, biomimetic aggregation‐induced emission (AIE) photosensitizers hitchhiking...
The success of tumor immunotherapy highlights the potential harnessing immune system to fight cancer. Activating both native T cells and exhausted is a critical step for generating effective antitumor immunity, which determined based on efficient presentation antigens co-stimulatory signals by antigen-presenting cells, as well immunosuppressive reversal. However, strategies achieving an antigen process improving microenvironment remain unresolved. Here, aggregation-induced-emission (AIE)...
Abstract Phototherapy is a promising treatment method for cancer therapy. However, the various factors have greatly restricted phototherapy development, including poor accumulation of photosensitizer in tumor, hypoxia solid tumor tissue and systemic phototoxicity. Herein, mitochondrial‐targeted multifunctional dye‐anchored manganese oxide nanoparticle (IR808@MnO NP) developed enhancing cancer. In this nanoplatform, IR808 as small molecule dye acts targeting ligand to make IR808@MnO NPs with...
The precision oncology significantly relies on the development of multifunctional agents to integrate tumor targeting, imaging and therapeutics.In this study, a first small-molecule theranostic probe, RhoSSCy is constructed by conjugating 5′-carboxyrhodamines (Rho) heptamethine cyanine IR765 (Cy) using reducible disulfide linker pH tunable amino-group realize thiols/pH dual sensing.In vitro experiments verify that highly sensitive for quantitative analysis intracellular gradient...
Near-infrared (NIR) fluorescence imaging has relied on fluorophores that emit in the 700-900 nm NIR-Ia or 1,000-1,700 NIR-II window for generating deep-tissue images. Up until now, there have been few developed 900-1,000 NIR-Ib window. This is largely because light thought to be strongly absorbed by water. Methods: Here we found six heptamethine dyes had distinct emission peaks both and We tested performance of these contrast agents introducing them into leaves common house plant Epipremnum...
Butyrylcholinesterase (BChE) is an essential human biomarker which related to liver and neurodegenerative diseases. It of great significance develop a fluorescent probe that can image BChE in vitro vivo. Unfortunately, most probes are based on single change fluorescence intensity susceptible environmental interference. Therefore, we reported easily available ratiometric probe, TB-BChE, with aggregation-induced emission (AIE) characteristics for imaging BChE. TB-BChE demonstrated excellent...
Methylene blue (MB) is an FDA (Food and Drug Administration)-approved contrast agent with donor-acceptor (D-A) structure integrated carbonyl-containing nitrogen-heterocycles. MB can be converted into MBH (protonated MB) by protonation, which not only induces the fluorescence emission red-shifted from first near-infrared window (NIR-I, 650-950 nm) to second (NIR-II, 1000-1700 but also achieves ACQ-to-AIE conversion. has been successfully demonstrated in hyperacidemia imaging extremely low pH...
Targeted phototherapy and multi-modal imaging can effectively improve the therapeutic efficacy reduce side effects of theranostics. Herein, we constructed novel biocompatible cyanine dye IR808-conjugated hyaluronic acid nanoparticles (HAIR NPs) for photothermal therapy (PTT) with near-infrared fluorescence (FL) photoacoustic (PA) dual-modal imaging. The formed stable nanostructures under aqueous conditions uniform size distribution. HAIR NPs were rapidly taken up by human lung cancer cells...
Abstract Immune checkpoint blockade (ICB) therapy has achieved remarkable therapeutic effects in cancer, but it is not effective glioblastoma (GBM). The main reason that difficult for drugs to penetrate blood‐brain‐barrier (BBB) GBM and lacks enough pre‐existing cytotoxic CD8 + T cells microenvironment. Here, two AIE photothermal agents (Fs Fo) are synthesized with NIR‐II fluorescence emission increase molecular twisting of by simply changing one O atom into S atom, improving Fs conversion...
Abstract Cancer immunotherapy has attracted considerable attention due to its advantages of persistence, targeting, and ability kill tumor cells. However, the efficacy in practical applications is limited by heterogeneity complex immunosuppressive microenvironments which abundant M2 macrophages immune checkpoints (ICs) are present. Herein, two type‐I aggregation‐induced emission (AIE)‐active photosensitizers with various reactive oxygen species (ROS)‐generating efficiencies designed...
Near-infrared (NIR) organic dyes have received increasing attention in recent years as diagnostic and therapeutic agents the field of tumor research. In this study, IR-822, a near-infrared fluorescence (NIRF) heptamethine cyanine dye, was chosen fluorophore due to its high extinction coefficients, native preferential accumulation property. To enhance specificity imaging, N1-(pyridin-4-ylmethyl)ethane-1,2-diamine (PY) conjugated IR-822 pH-sensing receptor, forming fluorophore-spacer-receptor...
Immune checkpoint blockade (ICB) has shown promising potential for treating triple-negative breast cancer (TNBC), but its efficacy is limited, mainly due to the "cold," suppressive immune tumor microenvironment (TME). Therefore, improving TME crucial enhancing therapeutic effects against TNBC. Here, we presented a multifunctional nanotherapeutic platform (ALEvs@LNPs) designed combine cytokine-sensitized mild photothermal therapy, ICB, and interleukin-2 (IL2) mRNA therapy reprogram TME,...
<title>Abstract</title> <bold>Background:</bold> Although abnormal amygdala functional connectivity (FC) has been reported in schizophrenia, most studies have treated the as a single structure. This study aimed to explore association between subregional FC and anhedonia patients with first-episode schizophrenia (FES). <bold>Methods:</bold> Resting-state magnetic resonance imaging (fMRI) was conducted 31 FES (including 11 drug-naïve) 33 matched healthy controls (HCs). Clinical symptoms were...
Chemo-photothermal combination therapy has already become a promising strategy for cancer treatment.
Recently, we identified aminothiazole derivatives of GE2270 A. These novel semisynthetic congeners, like A, target the essential bacterial protein elongation factor Tu (EF-Tu). Medicinal chemistry optimization lead molecules led to identification preclinical development candidates 1 and 2. cycloalklycarboxylic acid show activity against difficult treat Gram-positive pathogens demonstrate increased aqueous solubility compared We describe here in vitro vivo activities compounds 2 marketed...